Aliases for C14orf132 Gene

Aliases for C14orf132 Gene

  • Chromosome 14 Open Reading Frame 132 2 3 5
  • Uncharacterized Protein C14orf132 3 4
  • C14orf88 3 4
  • Chromosome 14 Open Reading Frame 88 2
  • C14orf132 5

External Ids for C14orf132 Gene

Previous HGNC Symbols for C14orf132 Gene

  • C14orf88

Previous GeneCards Identifiers for C14orf132 Gene

  • GC14P090373
  • GC14P094546
  • GC14P094495
  • GC14P095575
  • GC14P096505
  • GC14P076690

Summaries for C14orf132 Gene

GeneCards Summary for C14orf132 Gene

C14orf132 (Chromosome 14 Open Reading Frame 132) is a Protein Coding gene. Diseases associated with C14orf132 include Hepatocellular Carcinoma and Lung Cancer.

Additional gene information for C14orf132 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C14orf132 Gene

Genomics for C14orf132 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C14orf132 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J096038 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 259.2 +0.5 539 3 ZBTB10 CTCF ZIC2 KLF9 SP2 ZNF2 ZBTB48 POLR2A ZNF189 MXD3 C14orf132 HSALNG0103473 BDKRB2
GH14J095290 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 13.5 -747.7 -747698 2.4 ZFP64 POLR2A ZIC2 ZNF513 ZNF521 ZNF639 ZNF148 RXRA ZNF132 KLF9 lnc-GLRX5-5 SNHG10 SCARNA13 CLMN C14orf132 DICER1 piR-36588-165
GH14J096052 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 +15.4 15438 4 CTCF ZIC2 MAFF ZNF341 SMC3 RAD21 NFE2 ZNF2 INSM2 ZBTB48 C14orf132 HSALNG0103475 lnc-ATG2B-10 BDKRB2
GH14J096101 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +64.7 64726 7.8 CEBPA MNT ZNF217 CTCF BHLHE40 THAP11 CEBPB REST MBD2 CUX1 BDKRB2 C14orf132 BDKRB1 HSALNG0103478 lnc-C14orf132-3
GH14J096089 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.6 +52.2 52159 3.8 FEZF1 ZIC2 ZNF341 CTCF ZBTB48 ZNF189 GLIS1 RCOR1 GATA2 POLR2A HSALNG0103476 C14orf132 lnc-ATG2B-9 BDKRB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C14orf132 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C14orf132

Top Transcription factor binding sites by QIAGEN in the C14orf132 gene promoter:
  • AML1a
  • c-Myc
  • Egr-4
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA5
  • Max1
  • XBP-1
  • ZID

Genomic Locations for C14orf132 Gene

Latest Assembly
chr14:96,039,362-96,093,971
(GRCh38/hg38)
Size:
54,610 bases
Orientation:
Plus strand

Previous Assembly
chr14:96,505,699-96,560,308
(GRCh37/hg19 by Entrez Gene)
Size:
54,610 bases
Orientation:
Plus strand

chr14:96,505,661-96,560,417
(GRCh37/hg19 by Ensembl)
Size:
54,757 bases
Orientation:
Plus strand

Genomic View for C14orf132 Gene

Genes around C14orf132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf132 Gene

Proteins for C14orf132 Gene

  • Protein details for C14orf132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPU4-CN132_HUMAN
    Recommended name:
    Uncharacterized protein C14orf132
    Protein Accession:
    Q9NPU4
    Secondary Accessions:
    • B2R7K5

    Protein attributes for C14orf132 Gene

    Size:
    83 amino acids
    Molecular mass:
    8830 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG35852.1; Type=Erroneous translation; Evidence={ECO:0000305}; Sequence=CAB99085.1; Type=Erroneous translation; Evidence={ECO:0000305}; Sequence=EAW81627.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C14orf132 Gene

Post-translational modifications for C14orf132 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C14orf132 Gene

Domains & Families for C14orf132 Gene

Gene Families for C14orf132 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C14orf132 Gene

ProtoNet:
genes like me logo Genes that share domains with C14orf132: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C14orf132 Gene

Function for C14orf132 Gene

Phenotypes From GWAS Catalog for C14orf132 Gene

Phenotypes for C14orf132 Gene

genes like me logo Genes that share phenotypes with C14orf132: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf132

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf132 Gene

Localization for C14orf132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf132 Gene

Membrane. Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for C14orf132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf132: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for C14orf132 Gene

Pathways & Interactions for C14orf132 Gene

PathCards logo

SuperPathways for C14orf132 Gene

No Data Available

Interacting Proteins for C14orf132 Gene

Gene Ontology (GO) - Biological Process for C14orf132 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf132 Gene

Drugs & Compounds for C14orf132 Gene

No Compound Related Data Available

Transcripts for C14orf132 Gene

mRNA/cDNA for C14orf132 Gene

5 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf132

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf132 Gene

No ASD Table

Relevant External Links for C14orf132 Gene

GeneLoc Exon Structure for
C14orf132

Expression for C14orf132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf132 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf132 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7) and Brain - Cerebellar Hemisphere (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C14orf132

SOURCE GeneReport for Unigene cluster for C14orf132 Gene:

Hs.6434
genes like me logo Genes that share expression patterns with C14orf132: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf132 Gene

Orthologs for C14orf132 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf132 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC743753 30
  • 98.83 (n)
Cow
(Bos Taurus)
Mammalia C21H14orf132 30
  • 87.55 (n)
Species where no ortholog for C14orf132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C14orf132 Gene

ENSEMBL:
Gene Tree for C14orf132 (if available)
TreeFam:
Gene Tree for C14orf132 (if available)

Paralogs for C14orf132 Gene

No data available for Paralogs for C14orf132 Gene

Variants for C14orf132 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C14orf132 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C14orf132 Gene

Variant ID Type Subtype PubMed ID
esv24297 CNV loss 19812545
esv2657868 CNV deletion 23128226
esv3635413 CNV loss 21293372
nsv1046191 CNV gain 25217958
nsv1046685 CNV loss 25217958
nsv1131161 CNV deletion 24896259
nsv1415 CNV insertion 18451855
nsv520884 CNV loss 19592680
nsv832866 CNV gain 17160897

Variation tolerance for C14orf132 Gene

Gene Damage Index Score: 0.36; 7.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf132

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C14orf132 Gene

Disorders for C14orf132 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C14orf132 Gene - From: LNC and COP

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C14orf132

genes like me logo Genes that share disorders with C14orf132: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C14orf132 Gene

Publications for C14orf132 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Identification and validation of long noncoding RNA biomarkers in human non-small-cell lung carcinomas. (PMID: 25590602) Yu H … Meng X (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2015) 74
  3. Long non-coding RNAs are differentially expressed in hepatocellular carcinoma cell lines with differing metastatic potential. (PMID: 25556502) Fang TT … Liu BB (Asian Pacific journal of cancer prevention : APJCP 2014) 74
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4

Products for C14orf132 Gene

Sources for C14orf132 Gene