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Aliases for C14orf132 Gene

Aliases for C14orf132 Gene

  • Chromosome 14 Open Reading Frame 132 2 3 5
  • C14orf88 3 4
  • Chromosome 14 Open Reading Frame 88 2
  • Uncharacterized Protein C14orf132 3

External Ids for C14orf132 Gene

Previous HGNC Symbols for C14orf132 Gene

  • C14orf88

Previous GeneCards Identifiers for C14orf132 Gene

  • GC14P090373
  • GC14P094546
  • GC14P094495
  • GC14P095575
  • GC14P096505
  • GC14P076690

Summaries for C14orf132 Gene

GeneCards Summary for C14orf132 Gene

C14orf132 (Chromosome 14 Open Reading Frame 132) is a Protein Coding gene.

Additional gene information for C14orf132 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf132 Gene

Genomics for C14orf132 Gene

GeneHancer (GH) Regulatory Elements for C14orf132 Gene

Promoters and enhancers for C14orf132 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I096038 Promoter/Enhancer 1.3 Ensembl ENCODE 558 +0.5 454 2.1 ZSCAN4 SIN3A THRB ZNF335 SCRT2 EGR2 SP3 RXRA USF2 ZNF398 C14orf132 BDKRB2
GH14I096040 Enhancer 0.3 ENCODE 550.8 +1.7 1655 0.2 RFX1 C14orf132 BDKRB2
GH14I096052 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.4 +14.9 14887 2.6 INSM2 KLF17 EBF1 ZIC2 ZNF2 ZFHX2 GLIS2 POLR2A ZNF366 ZBTB48 C14orf132 BDKRB2
GH14I096100 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +64.9 64913 7.3 FOXA2 NEUROD1 SIN3A ZNF2 YY1 ZNF143 ATF7 FOS RUNX3 ZNF263 PAPOLA BDKRB2 SCARNA13 DICER1 SNHG10 C14orf132 BDKRB1
GH14I096089 Enhancer 1.1 Ensembl ENCODE dbSUPER 6.6 +52.1 52133 3.6 MZF1 FEZF1 ZIC2 ZNF507 POLR2A ZBTB48 EGR1 PRDM10 RCOR1 FOS C14orf132 BDKRB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf132 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf132 gene promoter:

Genomic Locations for C14orf132 Gene

Genomic Locations for C14orf132 Gene
chr14:96,039,324-96,093,971
(GRCh38/hg38)
Size:
54,648 bases
Orientation:
Plus strand
chr14:96,505,661-96,560,417
(GRCh37/hg19)

Genomic View for C14orf132 Gene

Genes around C14orf132 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf132 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf132 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf132 Gene

Proteins for C14orf132 Gene

  • Protein details for C14orf132 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPU4-CN132_HUMAN
    Recommended name:
    Uncharacterized protein C14orf132
    Protein Accession:
    Q9NPU4
    Secondary Accessions:
    • B2R7K5

    Protein attributes for C14orf132 Gene

    Size:
    83 amino acids
    Molecular mass:
    8830 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG35852.1; Type=Erroneous translation; Evidence={ECO:0000305}; Sequence=CAB99085.1; Type=Erroneous translation; Evidence={ECO:0000305}; Sequence=EAW81627.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C14orf132 Gene

Post-translational modifications for C14orf132 Gene

No Post-translational modifications

Other Protein References for C14orf132 Gene

No data available for DME Specific Peptides for C14orf132 Gene

Domains & Families for C14orf132 Gene

Gene Families for C14orf132 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C14orf132 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf132: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf132 Gene

Function for C14orf132 Gene

Phenotypes From GWAS Catalog for C14orf132 Gene

Phenotypes for C14orf132 Gene

GenomeRNAi human phenotypes for C14orf132:
genes like me logo Genes that share phenotypes with C14orf132: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf132 Gene

Localization for C14orf132 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf132 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf132 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C14orf132 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf132: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C14orf132 Gene

Pathways & Interactions for C14orf132 Gene

SuperPathways for C14orf132 Gene

No Data Available

Interacting Proteins for C14orf132 Gene

Gene Ontology (GO) - Biological Process for C14orf132 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf132 Gene

Drugs & Compounds for C14orf132 Gene

No Compound Related Data Available

Transcripts for C14orf132 Gene

Unigene Clusters for C14orf132 Gene

Chromosome 14 open reading frame 132:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf132 Gene

No ASD Table

Relevant External Links for C14orf132 Gene

GeneLoc Exon Structure for
C14orf132
ECgene alternative splicing isoforms for
C14orf132

Expression for C14orf132 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf132 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf132 Gene

This gene is overexpressed in Brain - Cerebellum (x4.7) and Brain - Cerebellar Hemisphere (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of C14orf132 Gene:

C14orf132

SOURCE GeneReport for Unigene cluster for C14orf132 Gene:

Hs.6434

Evidence on tissue expression from TISSUES for C14orf132 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with C14orf132: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf132 Gene

Orthologs for C14orf132 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf132 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC743753 33
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia C21H14orf132 33
  • 87.55 (n)
Species where no ortholog for C14orf132 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf132 Gene

ENSEMBL:
Gene Tree for C14orf132 (if available)
TreeFam:
Gene Tree for C14orf132 (if available)

Paralogs for C14orf132 Gene

No data available for Paralogs for C14orf132 Gene

Variants for C14orf132 Gene

Sequence variations from dbSNP and Humsavar for C14orf132 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000000137 -- 96,052,362(+) G/A intron_variant
rs1000021106 -- 96,044,005(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000129585 -- 96,046,349(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000177444 -- 96,083,554(+) G/A/C intron_variant
rs1000186271 -- 96,077,055(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf132 Gene

Variant ID Type Subtype PubMed ID
esv24297 CNV loss 19812545
esv2657868 CNV deletion 23128226
esv3635413 CNV loss 21293372
nsv1046191 CNV gain 25217958
nsv1046685 CNV loss 25217958
nsv1131161 CNV deletion 24896259
nsv1415 CNV insertion 18451855
nsv520884 CNV loss 19592680
nsv832866 CNV gain 17160897

Variation tolerance for C14orf132 Gene

Gene Damage Index Score: 0.36; 7.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf132 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf132

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf132 Gene

Disorders for C14orf132 Gene

Additional Disease Information for C14orf132

No disorders were found for C14orf132 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf132 Gene

Publications for C14orf132 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58

Products for C14orf132 Gene

Sources for C14orf132 Gene

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