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Aliases for C14orf119 Gene

Aliases for C14orf119 Gene

  • Chromosome 14 Open Reading Frame 119 2 3 5

External Ids for C14orf119 Gene

Previous GeneCards Identifiers for C14orf119 Gene

  • GC00U900532
  • GC14P021555
  • GC14P021556
  • GC14P021557
  • GC14P022634
  • GC14P023563
  • GC14P003681
  • GC14P023394
  • GC14P023559
  • GC14P023673
  • GC14P023796
  • GC14P023886
  • GC14P023945
  • GC14P024058

Summaries for C14orf119 Gene

GeneCards Summary for C14orf119 Gene

C14orf119 (Chromosome 14 Open Reading Frame 119) is a Protein Coding gene.

Additional gene information for C14orf119 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf119 Gene

Genomics for C14orf119 Gene

GeneHancer (GH) Regulatory Elements for C14orf119 Gene

Promoters and enhancers for C14orf119 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I023093 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 560.4 +0.5 501 3.3 ZFP64 DMAP1 YBX1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPARGC1A ACIN1 C14orf119 RBM23 NGDN BCL2L2-PABPN1 PRMT5 OXA1L HOMEZ LRP10 LOC102724814
GH14I022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.5 -114.9 -114859 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN PRMT5 C14orf93 HAUS4 RBM23 LOC102724814 PABPN1 MMP14
GH14I022955 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.7 -138.2 -138160 2.6 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HAUS4 MIR4707 ACIN1 C14orf93 C14orf119 RBM23 LOC102724814 PRMT5 AJUBA PSMB5
GH14I023005 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.7 -86.4 -86427 4.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 C14orf93 ENSG00000280129 ACIN1 RBM23 HAUS4 PRMT5 LOC102724814 C14orf119 PRMT5-AS1 NGDN
GH14I023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12 -24.3 -24303 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 NGDN LOC102724814 RBM23 HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf119 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf119 gene promoter:

Genomic Locations for C14orf119 Gene

Genomic Locations for C14orf119 Gene
chr14:23,094,765-23,100,462
(GRCh38/hg38)
Size:
5,698 bases
Orientation:
Plus strand
chr14:23,563,974-23,569,665
(GRCh37/hg19)

Genomic View for C14orf119 Gene

Genes around C14orf119 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf119 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf119 Gene

Proteins for C14orf119 Gene

  • Protein details for C14orf119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWQ9-CN119_HUMAN
    Recommended name:
    Uncharacterized protein C14orf119
    Protein Accession:
    Q9NWQ9
    Secondary Accessions:
    • Q6IAA7

    Protein attributes for C14orf119 Gene

    Size:
    140 amino acids
    Molecular mass:
    16009 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf119 Gene

Post-translational modifications for C14orf119 Gene

  • Ubiquitination at posLast=128128 and Lys139
  • Modification sites at PhosphoSitePlus

Other Protein References for C14orf119 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C14orf119 Gene

Domains & Families for C14orf119 Gene

Gene Families for C14orf119 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C14orf119 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf119: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf119 Gene

Function for C14orf119 Gene

Phenotypes From GWAS Catalog for C14orf119 Gene

Phenotypes for C14orf119 Gene

genes like me logo Genes that share phenotypes with C14orf119: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf119 Gene

Localization for C14orf119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf119 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf119 gene
Compartment Confidence
mitochondrion 5
cytosol 5
extracellular 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C14orf119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C14orf119: view

Pathways & Interactions for C14orf119 Gene

SuperPathways for C14orf119 Gene

No Data Available

Interacting Proteins for C14orf119 Gene

Selected Interacting proteins: Q9NWQ9-CN119_HUMAN for C14orf119 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for C14orf119 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf119 Gene

Drugs & Compounds for C14orf119 Gene

No Compound Related Data Available

Transcripts for C14orf119 Gene

mRNA/cDNA for C14orf119 Gene

Unigene Clusters for C14orf119 Gene

Chromosome 14 open reading frame 119:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf119 Gene

No ASD Table

Relevant External Links for C14orf119 Gene

GeneLoc Exon Structure for
C14orf119
ECgene alternative splicing isoforms for
C14orf119

Expression for C14orf119 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf119 Gene

Protein differential expression in normal tissues from HIPED for C14orf119 Gene

This gene is overexpressed in Bone (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf119 Gene



Protein tissue co-expression partners for C14orf119 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf119 Gene:

C14orf119

SOURCE GeneReport for Unigene cluster for C14orf119 Gene:

Hs.525238

Evidence on tissue expression from TISSUES for C14orf119 Gene

  • Nervous system(4.7)
  • Intestine(4.3)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with C14orf119: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf119 Gene

Orthologs for C14orf119 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf119 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf119 34
  • 100 (a)
OneToOne
C14H14orf119 33
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia C8H14orf119 33
  • 93.73 (n)
-- 34
  • 87 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C10H14orf119 33
  • 91.74 (n)
C14orf119 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700123O20Rik 33 16 34
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia RGD1308430 33
  • 86.43 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf119 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf119 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf119 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf119 33
  • 63 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-14a17.11 33
  • 49.88 (n)
C2H14orf119 34
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Species where no ortholog for C14orf119 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf119 Gene

ENSEMBL:
Gene Tree for C14orf119 (if available)
TreeFam:
Gene Tree for C14orf119 (if available)

Paralogs for C14orf119 Gene

Pseudogenes.org Pseudogenes for C14orf119 Gene

genes like me logo Genes that share paralogs with C14orf119: view

No data available for Paralogs for C14orf119 Gene

Variants for C14orf119 Gene

Sequence variations from dbSNP and Humsavar for C14orf119 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000883684 -- 23,095,723(+) C/T 5_prime_UTR_variant, intron_variant
rs1001705922 -- 23,096,230(+) C/G intron_variant
rs1001777952 -- 23,094,476(+) G/A/C upstream_transcript_variant
rs1002044926 -- 23,098,208(+) G/A 3_prime_UTR_variant
rs1002110801 -- 23,096,605(+) C/T intron_variant

Variation tolerance for C14orf119 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf119 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf119

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf119 Gene

Disorders for C14orf119 Gene

Additional Disease Information for C14orf119

No disorders were found for C14orf119 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf119 Gene

Publications for C14orf119 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart AE … Wells CM (The Journal of cell biology 2015) 3 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PMID: 22361696) Stadler C … Lundberg E (Journal of proteomics 2012) 4 58

Products for C14orf119 Gene

Sources for C14orf119 Gene

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