Aliases for C14orf28 Gene

Aliases for C14orf28 Gene

  • Chromosome 14 Open Reading Frame 28 2 3 5
  • DRIP1 2 3 4
  • Dopamine Receptor Interacting Protein 1 2 3
  • Uncharacterized Protein C14orf28 3 4
  • DRIP-1 2 3
  • Dopamine Receptor-Interacting Protein 1 4
  • C14_5270 3
  • C14orf28 5

External Ids for C14orf28 Gene

Previous GeneCards Identifiers for C14orf28 Gene

  • GC14P039162
  • GC14P043356
  • GC14P044436
  • GC14P045366
  • GC14P025477

Summaries for C14orf28 Gene

GeneCards Summary for C14orf28 Gene

C14orf28 (Chromosome 14 Open Reading Frame 28) is a Protein Coding gene. Diseases associated with C14orf28 include Acute Hemorrhagic Conjunctivitis.

Additional gene information for C14orf28 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C14orf28 Gene

Genomics for C14orf28 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C14orf28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J044895 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.0 41 4.2 CHD2 MXD4 MNT ELF1 THAP11 SIN3A ELK1 SIN3B FOXA2 MAX C14orf28 ENSG00000258633 LINC02302 MIS18BP1 piR-57460-179 ENSG00000258949 LOC101927418 TOGARAM1 lnc-C14orf28-2
GH14J045248 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.4 +354.5 354528 6.4 CHD2 TBP SP1 BCL11A MXD4 CEBPA NR2C1 IKZF1 SMAD5 ETS1 MIS18BP1 ENSG00000257900 lnc-FANCM-1-001 PRPF39 FANCM KLHL28 C14orf28 lnc-FKBP3-5
GH14J044959 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +67.0 66972 9.5 ZSCAN16 TBP ZBTB10 SP1 FEZF1 CEBPA SIX5 NR2C1 MNT SMAD5 KLHL28 TOGARAM1 PRPF39 FANCM MIS18BP1 C14orf28 LINC02302 HSALNG0100944 lnc-KLHL28-3
GH14J044955 Enhancer 0.4 Ensembl 10.9 +58.6 58625 1 CEBPA GLIS1 CEBPG HLF C14orf28 LINC02302 TOGARAM1 HSALNG0100941 KLHL28
GH14J044954 Enhancer 0.3 Ensembl 10.9 +57.5 57526 0.8 CEBPB CEBPG C14orf28 LINC02302 HSALNG0100941 TOGARAM1 KLHL28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C14orf28 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C14orf28

Top Transcription factor binding sites by QIAGEN in the C14orf28 gene promoter:
  • c-Ets-1
  • FOXO1
  • FOXO1a
  • HSF1 (long)
  • HSF1short
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • POU6F1 (c2)
  • SRY

Genomic Locations for C14orf28 Gene

Latest Assembly
chr14:44,897,275-44,907,257
(GRCh38/hg38)
Size:
9,983 bases
Orientation:
Plus strand

Previous Assembly
chr14:45,366,478-45,376,460
(GRCh37/hg19 by Entrez Gene)
Size:
9,983 bases
Orientation:
Plus strand

chr14:45,366,498-45,376,460
(GRCh37/hg19 by Ensembl)
Size:
9,963 bases
Orientation:
Plus strand

Genomic View for C14orf28 Gene

Genes around C14orf28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf28 Gene

Proteins for C14orf28 Gene

  • Protein details for C14orf28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4W4Y0-CN028_HUMAN
    Recommended name:
    Uncharacterized protein C14orf28
    Protein Accession:
    Q4W4Y0

    Protein attributes for C14orf28 Gene

    Size:
    310 amino acids
    Molecular mass:
    36306 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf28 Gene

Post-translational modifications for C14orf28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf28 Gene

No data available for DME Specific Peptides for C14orf28 Gene

Domains & Families for C14orf28 Gene

Gene Families for C14orf28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C14orf28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C14orf28 Gene

GenScript: Design optimal peptide antigens:
  • Dopamine receptor-interacting protein 1 (CN028_HUMAN)
  • Similar to hypothetical gene LOC122525 (Q8N0U0_HUMAN)
genes like me logo Genes that share domains with C14orf28: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C14orf28 Gene

Function for C14orf28 Gene

Phenotypes From GWAS Catalog for C14orf28 Gene

Phenotypes for C14orf28 Gene

genes like me logo Genes that share phenotypes with C14orf28: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf28

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf28 Gene

Localization for C14orf28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf28 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf28 Gene

Pathways & Interactions for C14orf28 Gene

PathCards logo

SuperPathways for C14orf28 Gene

No Data Available

Interacting Proteins for C14orf28 Gene

Gene Ontology (GO) - Biological Process for C14orf28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf28 Gene

Drugs & Compounds for C14orf28 Gene

No Compound Related Data Available

Transcripts for C14orf28 Gene

mRNA/cDNA for C14orf28 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf28

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf28 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for C14orf28 Gene

GeneLoc Exon Structure for
C14orf28

Expression for C14orf28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Heart (Cardiovascular System)

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C14orf28

SOURCE GeneReport for Unigene cluster for C14orf28 Gene:

Hs.82098
genes like me logo Genes that share expression patterns with C14orf28: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf28 Gene

Orthologs for C14orf28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf28 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C14H14orf28 30
  • 99.68 (n)
C14orf28 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C14ORF28 31
  • 98 (a)
OneToOne
C8H14orf28 30
  • 96.45 (n)
Cow
(Bos Taurus)
Mammalia C14orf28 31
  • 98 (a)
OneToOne
C21H14orf28 30
  • 95 (n)
Oppossum
(Monodelphis domestica)
Mammalia C14orf28 31
  • 97 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1307621 30
  • 94.41 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia C14orf28 31
  • 94 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm527 30 17 31
  • 93.87 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100494240 30
  • 76.02 (n)
Zebrafish
(Danio rerio)
Actinopterygii C14orf28 31
  • 64 (a)
OneToOne
LOC100333462 30
  • 62.03 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7573 30
Species where no ortholog for C14orf28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C14orf28 Gene

ENSEMBL:
Gene Tree for C14orf28 (if available)
TreeFam:
Gene Tree for C14orf28 (if available)

Paralogs for C14orf28 Gene

No data available for Paralogs for C14orf28 Gene

Variants for C14orf28 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C14orf28 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs115254671 Benign: not provided 44,903,212(+) C/T
NM_001017923.2(C14orf28):c.530C>T (p.Pro177Leu)
MISSENSE
rs61742835 Benign: not provided 44,905,544(+) G/T
NM_001017923.2(C14orf28):c.927G>T (p.Glu309Asp)
MISSENSE
rs61978647 Benign: not provided 44,900,633(+) A/G
NM_001017923.2(C14orf28):c.198A>G (p.Leu66=)
SYNONYMOUS
rs76976586 Benign: not provided 44,904,481(+) C/T
NM_001017923.2(C14orf28):c.701C>T (p.Ser234Phe)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C14orf28 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C14orf28 Gene

Variant ID Type Subtype PubMed ID
nsv1053437 CNV loss 25217958
nsv1258 CNV insertion 18451855
nsv564642 CNV loss 21841781

Variation tolerance for C14orf28 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf28 Gene

Human Gene Mutation Database (HGMD)
C14orf28
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf28

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf28 Gene

Disorders for C14orf28 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C14orf28 Gene - From: COP

Disorder Aliases PubMed IDs
acute hemorrhagic conjunctivitis
  • apollo disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C14orf28

genes like me logo Genes that share disorders with C14orf28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C14orf28 Gene

Publications for C14orf28 Gene

  1. C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer. (PMID: 28455792) Yang X … Tang H (Molecular and cellular biochemistry 2017) 2 3
  2. Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. (PMID: 20874815) Zhan L … Nasir J (Neuropathology and applied neurobiology 2011) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for C14orf28 Gene

Sources for C14orf28 Gene