C12orf77 Gene (RNA Gene)

Chromosome 12 Putative Open Reading Frame 77

GC12M024993
GIFtS:
23
See more...

Aliases for C12orf77 Gene

Data sources for C12orf77 Gene:

Subcategory (RNA class) for C12orf77 Gene

lncRNA

Aliases for C12orf77 Gene

External Ids for C12orf77 Gene

Previous GeneCards Identifiers for C12orf77 Gene

  • GC12M025038
  • GC12M025146
  • GC12M024916

Summaries for C12orf77 Gene

GeneCards Summary for C12orf77 Gene

C12orf77 (Chromosome 12 Putative Open Reading Frame 77) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for C12orf77 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C12orf77 Gene

Genomics for C12orf77 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for C12orf77 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J025004 Enhancer 0.8 Ensembl ENCODE 262.9 +0.9 877 1.3 SMARCA5 BHLHE40 ELF1 NFATC1 IKZF1 TCF7 BMI1 ATF2 ARID3A ATF7 C12orf77 IRAG2 BCAT1 LOC645177 DNAI7
GH12J025005 Enhancer 0.3 Ensembl 250.7 +1.8 1802 0.4 EBF1 TBL1XR1 C12orf77 IRAG2 BCAT1 LOC645177 DNAI7
GH12J024995 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 23.6 +9.1 9090 4.2 BCL11A NR2C1 SIN3A IRF4 EBF1 SMARCA5 MAX CBFB GLI4 BHLHE40 LOC645177 C12orf77 IRAG2 piR-56759-108 BCAT1
GH12J024943 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 6.2 +58.1 58083 9.6 TBP ZBTB10 SP1 BCL11A MXD4 CEBPA MNT IKZF1 SMAD5 ETS1 BCAT1 ENSG00000255921 lnc-CASC1-4 C12orf77 KRAS DNAI7 HSALNG0089884 lnc-BCAT1-6 SOX5
GH12J024991 Enhancer 0.8 Ensembl ENCODE 14.2 +14.7 14702 0.6 CTCF REST ZNF639 TRIM22 SMC3 RAD21 SMARCA5 ZNF2 MYC MAX C12orf77 piR-56759-108 LOC645177 BRI3P2 lnc-BCAT1-3 BCAT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C12orf77 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C12orf77

Genomic Locations for C12orf77 Gene

Latest Assembly
chr12:24,993,423-25,006,403
(GRCh38/hg38)
Size:
12,981 bases
Orientation:
Minus strand

Previous Assembly
chr12:25,146,358-25,150,399
(GRCh37/hg19 by Entrez Gene)
Size:
4,042 bases
Orientation:
Minus strand

chr12:25,146,358-25,150,453
(GRCh37/hg19 by Ensembl)
Size:
4,096 bases
Orientation:
Minus strand

Genomic View for C12orf77 Gene

Genes around C12orf77 on UCSC Golden Path with GeneCards custom track
C12orf77 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
C12orf77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf77 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C12orf77 Gene

Proteins for C12orf77 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for C12orf77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JDV5-CL097_HUMAN
    Recommended name:
    Putative uncharacterized protein C12orf77
    Protein Accession:
    C9JDV5

    Protein attributes for C12orf77 Gene

    Size:
    145 amino acids
    Molecular mass:
    16178 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf77 Gene

Post-translational modifications for C12orf77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C12orf77 Gene

Domains & Families for C12orf77 Gene

Protein Domains for C12orf77 Gene

ProtoNet:
genes like me logo Genes that share domains with C12orf77: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C12orf77 Gene

Function for C12orf77 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for C12orf77 Gene

Phenotypes for C12orf77 Gene

GenomeRNAi human phenotypes for C12orf77:
genes like me logo Genes that share phenotypes with C12orf77: view

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C12orf77

Cell Lines for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf77 Gene

Localization for C12orf77 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf77 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C12orf77 Gene

Pathways & Interactions for C12orf77 Gene

PathCards logo

SuperPathways for C12orf77 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C12orf77 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for C12orf77 Gene

Drugs & Compounds for C12orf77 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for C12orf77 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

Non-coding RNA (ncRNA) Transcripts from RNAcentral for C12orf77 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00007C6E4D_9606 lncRNA 1520 2

Ensembl: ENST00000623395 (view in UCSC) ,

LNCipedia: lnc-BCAT1-4:5,

URS0000A99657_9606 lncRNA 1447 2

Ensembl: ENST00000549262 (view in UCSC) ,

LNCipedia: lnc-BCAT1-4:2,

URS00007CC520_9606 lncRNA 675 2

Ensembl: ENST00000434912 (view in UCSC) ,

LNCipedia: lnc-BCAT1-4:6,

URS00008BC2AE_9606 lncRNA 1102 3

LncBook: HSALNT0186711,

LNCipedia: lnc-BCAT1-4:4,

NONCODE: NONHSAT027337.2,

URS00007E1794_9606 lncRNA 1237 1

LNCipedia: lnc-BCAT1-4:3,

C12orf77 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for C12orf77 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C12orf77

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf77 Gene

No ASD Table

Relevant External Links for C12orf77 Gene

GeneLoc Exon Structure for
C12orf77

Expression for C12orf77 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C12orf77 Gene

mRNA expression in normal human tissues for C12orf77 Gene
mRNA expression by BioGPS for C12orf77 GenemRNA expression by GTEx for C12orf77 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C12orf77

SOURCE GeneReport for Unigene cluster for C12orf77 Gene:

Hs.434453
genes like me logo Genes that share expression patterns with C12orf77: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf77 Gene

Orthologs for C12orf77 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C12orf77 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C12H12orf77 30
  • 98.16 (n)
C12orf77 31
  • 97 (a)
 OneToOne
Species where no ortholog for C12orf77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C12orf77 Gene

ENSEMBL:
Gene Tree for C12orf77 (if available)
TreeFam:
Gene Tree for C12orf77 (if available)

Paralogs for C12orf77 Gene

No data available for Paralogs for C12orf77 Gene

Variants for C12orf77 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C12orf77 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs864161 - p.Leu131Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C12orf77 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C12orf77 Gene

Variant ID Type Subtype PubMed ID
dgv2412n54 CNV gain 21841781
esv2422312 CNV duplication 17116639
nsv469169 CNV gain 19166990
nsv469173 CNV gain 19166990
nsv469174 CNV loss 19166990
nsv557775 CNV gain 21841781
nsv557795 CNV loss 21841781

Variation tolerance for C12orf77 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C12orf77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf77

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf77 Gene

Disorders for C12orf77 Gene

Additional Disease Information for C12orf77

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C12orf77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf77 Gene

Publications for C12orf77 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 41
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

ExternalLinks

View latest publications for C12orf77 gene in Mastermind

Products for C12orf77 Gene

Sources for C12orf77 Gene