Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C12orf77 Gene

Aliases for C12orf77 Gene

  • Chromosome 12 Open Reading Frame 77 2 3 5

External Ids for C12orf77 Gene

Previous GeneCards Identifiers for C12orf77 Gene

  • GC12M025038
  • GC12M025146
  • GC12M024916

Summaries for C12orf77 Gene

GeneCards Summary for C12orf77 Gene

C12orf77 (Chromosome 12 Open Reading Frame 77) is a Protein Coding gene.

Additional gene information for C12orf77 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf77 Gene

Genomics for C12orf77 Gene

GeneHancer (GH) Regulatory Elements for C12orf77 Gene

Promoters and enhancers for C12orf77 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I025004 Enhancer 0.7 ENCODE 563 +0.9 940 1.2 PAX8 EBF1 BMI1 POLR2A NFATC1 ATF7 IKZF2 RUNX3 SRF SMARCA5 C12orf77 LRMP BCAT1 LOC645177
GH12I024995 Enhancer 1.2 FANTOM5 Ensembl ENCODE 23.6 +8.8 8817 3.7 PKNOX1 SMAD1 BMI1 GLI4 BATF IRF4 ZNF143 ATF7 ETV6 BCLAF1 LOC645177 C12orf77 LRMP
GH12I025050 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.8 -47.5 -47515 6.6 HDGF ATF1 PKNOX1 SMAD1 BATF KLF5 IRF4 ZBTB40 YY1 ZNF766 LRMP CASC1 ETFRF1 C12orf77 KRAS CENPUP2 LOC645177
GH12I024951 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 6.2 +54.2 54184 1.8 PKNOX1 ATF1 SMAD1 ARNT IRF4 ZNF207 ZNF143 ATF7 RUNX3 JUNB LRMP BCAT1 C12orf77 KRAS ENSG00000255921 BRI3P2
GH12I025057 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 6.1 -52.4 -52393 1.6 JUNB EBF1 BATF IRF4 JUND POLR2A BCL11A NFATC1 MLLT1 IKZF2 LRMP C12orf77 CASC1 CENPUP2 LOC645177
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C12orf77 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C12orf77 Gene

Genomic Locations for C12orf77 Gene
chr12:24,993,424-25,006,403
(GRCh38/hg38)
Size:
12,980 bases
Orientation:
Minus strand
chr12:25,146,358-25,150,453
(GRCh37/hg19)

Genomic View for C12orf77 Gene

Genes around C12orf77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf77 Gene

Proteins for C12orf77 Gene

  • Protein details for C12orf77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JDV5-CL097_HUMAN
    Recommended name:
    Putative uncharacterized protein C12orf77
    Protein Accession:
    C9JDV5

    Protein attributes for C12orf77 Gene

    Size:
    145 amino acids
    Molecular mass:
    16178 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf77 Gene

Post-translational modifications for C12orf77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf77 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C12orf77 Gene

Domains & Families for C12orf77 Gene

Protein Domains for C12orf77 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf77: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf77 Gene

Function for C12orf77 Gene

Phenotypes From GWAS Catalog for C12orf77 Gene

Phenotypes for C12orf77 Gene

GenomeRNAi human phenotypes for C12orf77:
genes like me logo Genes that share phenotypes with C12orf77: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf77 Gene

Localization for C12orf77 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf77 gene
Compartment Confidence
extracellular 2
plasma membrane 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C12orf77 Gene

Pathways & Interactions for C12orf77 Gene

SuperPathways for C12orf77 Gene

No Data Available

Interacting Proteins for C12orf77 Gene

Gene Ontology (GO) - Biological Process for C12orf77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf77 Gene

Drugs & Compounds for C12orf77 Gene

No Compound Related Data Available

Transcripts for C12orf77 Gene

mRNA/cDNA for C12orf77 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C12orf77 Gene

Chromosome 12 open reading frame 77:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf77 Gene

No ASD Table

Relevant External Links for C12orf77 Gene

GeneLoc Exon Structure for
C12orf77
ECgene alternative splicing isoforms for
C12orf77

Expression for C12orf77 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf77 Gene

NURSA nuclear receptor signaling pathways regulating expression of C12orf77 Gene:

C12orf77

SOURCE GeneReport for Unigene cluster for C12orf77 Gene:

Hs.434453
genes like me logo Genes that share expression patterns with C12orf77: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf77 Gene

Orthologs for C12orf77 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C12orf77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf77 33
  • 98.16 (n)
C12orf77 34
  • 97 (a)
OneToOne
Species where no ortholog for C12orf77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf77 Gene

ENSEMBL:
Gene Tree for C12orf77 (if available)
TreeFam:
Gene Tree for C12orf77 (if available)

Paralogs for C12orf77 Gene

No data available for Paralogs for C12orf77 Gene

Variants for C12orf77 Gene

Sequence variations from dbSNP and Humsavar for C12orf77 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001261393 -- 24,995,407(-) G/T intron_variant
rs1002075449 -- 24,994,773(-) G/A intron_variant
rs1002713233 -- 24,994,417(-) G/C intron_variant
rs1002730003 -- 24,994,601(-) C/A intron_variant
rs1002759367 -- 24,994,937(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf77 Gene

Variant ID Type Subtype PubMed ID
dgv2412n54 CNV gain 21841781
esv2422312 CNV duplication 17116639
nsv469169 CNV gain 19166990
nsv469173 CNV gain 19166990
nsv469174 CNV loss 19166990
nsv557775 CNV gain 21841781
nsv557795 CNV loss 21841781

Variation tolerance for C12orf77 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C12orf77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf77 Gene

Disorders for C12orf77 Gene

Additional Disease Information for C12orf77

No disorders were found for C12orf77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf77 Gene

Publications for C12orf77 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 44 58
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for C12orf77 Gene

Sources for C12orf77 Gene

Content
Loading form....