Aliases for C12orf73 Gene

Aliases for C12orf73 Gene

  • Chromosome 12 Open Reading Frame 73 2 3 5
  • Uncharacterized Protein C12orf73 3 4

External Ids for C12orf73 Gene

Previous GeneCards Identifiers for C12orf73 Gene

  • GC12M102870
  • GC12M104343
  • GC12M101403

Summaries for C12orf73 Gene

GeneCards Summary for C12orf73 Gene

C12orf73 (Chromosome 12 Open Reading Frame 73) is a Protein Coding gene.

Additional gene information for C12orf73 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C12orf73 Gene

Genomics for C12orf73 Gene

GeneHancer (GH) Regulatory Elements for C12orf73 Gene

Promoters and enhancers for C12orf73 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C12orf73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C12orf73 gene promoter:
  • Evi-1
  • FAC1
  • FOXO1
  • FOXO1a
  • p300
  • Pax-2
  • Pax-2a
  • Pax-5
  • RORalpha1

Genomic Locations for C12orf73 Gene

Genomic Locations for C12orf73 Gene
chr12:103,940,763-103,965,708
(GRCh38/hg38)
Size:
24,946 bases
Orientation:
Minus strand
chr12:104,343,980-104,359,486
(GRCh37/hg19)
Size:
15,507 bases
Orientation:
Minus strand

Genomic View for C12orf73 Gene

Genes around C12orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf73 Gene

Proteins for C12orf73 Gene

  • Protein details for C12orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YU5-CL073_HUMAN
    Recommended name:
    Uncharacterized protein C12orf73
    Protein Accession:
    Q69YU5

    Protein attributes for C12orf73 Gene

    Size:
    71 amino acids
    Molecular mass:
    8023 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf73 Gene

Post-translational modifications for C12orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C12orf73 Gene

Domains & Families for C12orf73 Gene

Gene Families for C12orf73 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C12orf73 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C12orf73: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C12orf73 Gene

Function for C12orf73 Gene

Phenotypes From GWAS Catalog for C12orf73 Gene

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf73 Gene

Localization for C12orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C12orf73 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf73 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C12orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C12orf73: view

Pathways & Interactions for C12orf73 Gene

PathCards logo

SuperPathways for C12orf73 Gene

No Data Available

Interacting Proteins for C12orf73 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000367330 Q69YU5-CL073_HUMAN for C12orf73 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C12orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf73 Gene

Drugs & Compounds for C12orf73 Gene

No Compound Related Data Available

Transcripts for C12orf73 Gene

mRNA/cDNA for C12orf73 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf73 Gene

No ASD Table

Relevant External Links for C12orf73 Gene

GeneLoc Exon Structure for
C12orf73
ECgene alternative splicing isoforms for
C12orf73

Expression for C12orf73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf73 Gene

Protein differential expression in normal tissues from HIPED for C12orf73 Gene

This gene is overexpressed in Heart (36.4) and Frontal cortex (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf73 Gene



NURSA nuclear receptor signaling pathways regulating expression of C12orf73 Gene:

C12orf73

SOURCE GeneReport for Unigene cluster for C12orf73 Gene:

Hs.42547

Evidence on tissue expression from TISSUES for C12orf73 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C12orf73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf73 Gene

Orthologs for C12orf73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf73 33
  • 100 (a)
OneToOne
C12H12orf73 32
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia C15H12orf73 32
  • 88.06 (n)
C12orf73 33
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf73 32
  • 85.13 (n)
C12orf73 33
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1190007I07Rik 17 33 32
  • 85.07 (n)
rat
(Rattus norvegicus)
Mammalia LOC691921 32
  • 82.59 (n)
oppossum
(Monodelphis domestica)
Mammalia C12orf73 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF73 33 32
  • 75.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf73 33
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf73 32
  • 68.85 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H12orf73 33
  • 71 (a)
OneToOne
si:ch211-68a17.7 32
  • 68.78 (n)
Species where no ortholog for C12orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf73 Gene

ENSEMBL:
Gene Tree for C12orf73 (if available)
TreeFam:
Gene Tree for C12orf73 (if available)

Paralogs for C12orf73 Gene

Pseudogenes.org Pseudogenes for C12orf73 Gene

genes like me logo Genes that share paralogs with C12orf73: view

No data available for Paralogs for C12orf73 Gene

Variants for C12orf73 Gene

Sequence variations from dbSNP and Humsavar for C12orf73 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000180615 -- 103,961,528(-) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000377654 -- 103,965,028(-) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000385508 -- 103,955,962(-) G/A 5_prime_UTR_variant, intron_variant
rs1000733591 -- 103,960,353(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000935131 -- 103,966,489(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf73 Gene

Variant ID Type Subtype PubMed ID
nsv560039 CNV gain 21841781

Variation tolerance for C12orf73 Gene

Gene Damage Index Score: 5.49; 71.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C12orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf73 Gene

Disorders for C12orf73 Gene

Additional Disease Information for C12orf73

No disorders were found for C12orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf73 Gene

Publications for C12orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56

Products for C12orf73 Gene

Sources for C12orf73 Gene