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Aliases for C11orf95 Gene

Aliases for C11orf95 Gene

  • Chromosome 11 Open Reading Frame 95 2 3 5
  • Uncharacterized Protein C11orf95 3

External Ids for C11orf95 Gene

Previous GeneCards Identifiers for C11orf95 Gene

  • GC11M063285
  • GC11M063527
  • GC11M059857

Summaries for C11orf95 Gene

GeneCards Summary for C11orf95 Gene

C11orf95 (Chromosome 11 Open Reading Frame 95) is a Protein Coding gene. Diseases associated with C11orf95 include Ependymoma and Chondroid Lipoma.

Additional gene information for C11orf95 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf95 Gene

Genomics for C11orf95 Gene

GeneHancer (GH) Regulatory Elements for C11orf95 Gene

Promoters and enhancers for C11orf95 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064183 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.4 -416.9 -416898 4.4 CLOCK MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GC11M064182 STIP1 TRPT1 IMMP1LP1 ENSG00000257086 SF1 FERMT3 C11orf95 ZNHIT2 PLCB3
GH11J064267 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 10.1 -501.9 -501925 7.2 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC GPR137 ZFPL1 SF1 POLA2 PLCB3 ENSG00000257086 TRMT112 DNAJC4 FAU LOC102723878
GH11J064640 Enhancer 0.7 dbSUPER 10.7 -872.8 -872814 3 HDAC1 MXI1 ZNF777 SUZ12 ZFHX2 GLIS2 ZNF366 ZNF600 EZH2 REST C11orf95 NRXN2 ENSG00000237410 GC11M064638 GC11M064637
GH11J063895 Enhancer 0.5 dbSUPER 4.9 -128.8 -128750 3.5 NFIC ZNF680 BHLHE40 REST MNT MYC MARK2 NAA40 C11orf95 PLA2G16 GC11M063888 TRR-CCT9-1
GH11J063760 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 0.7 +3.3 3315 9.8 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 ZNF143 ZFP91 ATL3 LOC105369332 NXF1 ENSG00000257086 WDR74 STX5 PLCB3 SNHG1 RTN3 C11orf95
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf95 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C11orf95 Gene

Genomic Locations for C11orf95 Gene
8,884 bases
Minus strand

Genomic View for C11orf95 Gene

Genes around C11orf95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf95 Gene

Proteins for C11orf95 Gene

  • Protein details for C11orf95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf95
    Protein Accession:
    Secondary Accessions:
    • A6NLS7
    • Q3C1V4

    Protein attributes for C11orf95 Gene

    678 amino acids
    Molecular mass:
    73197 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for C11orf95 Gene

Post-translational modifications for C11orf95 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf95 Gene

No data available for DME Specific Peptides for C11orf95 Gene

Domains & Families for C11orf95 Gene

Gene Families for C11orf95 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for C11orf95 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf95: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf95 Gene

Function for C11orf95 Gene

Gene Ontology (GO) - Molecular Function for C11orf95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with C11orf95: view

Phenotypes for C11orf95 Gene

genes like me logo Genes that share phenotypes with C11orf95: view

Animal Model Products

miRNA for C11orf95 Gene

miRTarBase miRNAs that target C11orf95

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf95 Gene

Localization for C11orf95 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C11orf95 Gene

Pathways & Interactions for C11orf95 Gene

SuperPathways for C11orf95 Gene

No Data Available

Interacting Proteins for C11orf95 Gene

Gene Ontology (GO) - Biological Process for C11orf95 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf95 Gene

Drugs & Compounds for C11orf95 Gene

No Compound Related Data Available

Transcripts for C11orf95 Gene

mRNA/cDNA for C11orf95 Gene

(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf95 Gene

Chromosome 11 open reading frame 95:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf95 Gene

No ASD Table

Relevant External Links for C11orf95 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf95 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C11orf95 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf95 Gene

Protein tissue co-expression partners for C11orf95 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf95 Gene:


SOURCE GeneReport for Unigene cluster for C11orf95 Gene:

genes like me logo Genes that share expression patterns with C11orf95: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf95 Gene

Orthologs for C11orf95 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf95 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf95 33
  • 97.92 (n)
(Bos Taurus)
Mammalia C29H11orf95 33
  • 91.36 (n)
(Canis familiaris)
Mammalia C18H11orf95 33
  • 88.51 (n)
(Mus musculus)
Mammalia 2700081O15Rik 16 33
  • 88.18 (n)
(Rattus norvegicus)
Mammalia RGD1560108 33
  • 87.98 (n)
Species where no ortholog for C11orf95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf95 Gene

Gene Tree for C11orf95 (if available)
Gene Tree for C11orf95 (if available)

Paralogs for C11orf95 Gene

No data available for Paralogs for C11orf95 Gene

Variants for C11orf95 Gene

Sequence variations from dbSNP and Humsavar for C11orf95 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000232889 -- 63,761,520(-) A/G 3_prime_UTR_variant
rs1000263763 -- 63,761,228(-) T/C 3_prime_UTR_variant
rs1000419927 -- 63,767,560(-) G/A intron_variant
rs1000592709 -- 63,765,146(-) C/A coding_sequence_variant, missense_variant
rs1000599644 -- 63,762,529(-) A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf95 Gene

Variant ID Type Subtype PubMed ID
esv24244 CNV loss 19812545
esv33170 CNV gain 17666407
nsv1070464 CNV deletion 25765185
nsv1136128 CNV deletion 24896259
nsv1143684 CNV deletion 24896259
nsv555180 CNV loss 21841781
nsv832183 CNV loss 17160897
nsv975941 CNV duplication 23825009

Additional Variant Information for C11orf95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C11orf95 Gene

Disorders for C11orf95 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C11orf95 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
  • cellular ependymoma
chondroid lipoma
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving MKL2 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MKL2 produces a C11orf95-MKL2 fusion protein (PubMed:20607705). {ECO:0000269 PubMed:20607705}.
  • Note=A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269 PubMed:24553141}.

Additional Disease Information for C11orf95

genes like me logo Genes that share disorders with C11orf95: view

No data available for Genatlas for C11orf95 Gene

Publications for C11orf95 Gene

  1. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. (PMID: 20607705) Huang D … Bridge JA (Genes, chromosomes & cancer 2010) 2 3 4 58
  2. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. (PMID: 24553141) Parker M … Gilbertson RJ (Nature 2014) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. (PMID: 27121356) Nambirajan A … Garg A (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3 58
  5. Biology and management of ependymomas. (PMID: 27022130) Wu J … Gilbert MR (Neuro-oncology 2016) 3 58

Products for C11orf95 Gene

Sources for C11orf95 Gene

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