Aliases for C11orf95 Gene

Aliases for C11orf95 Gene

  • Chromosome 11 Open Reading Frame 95 2 3 5
  • Uncharacterized Protein C11orf95 3 4

External Ids for C11orf95 Gene

Previous GeneCards Identifiers for C11orf95 Gene

  • GC11M063285
  • GC11M063527
  • GC11M059857

Summaries for C11orf95 Gene

GeneCards Summary for C11orf95 Gene

C11orf95 (Chromosome 11 Open Reading Frame 95) is a Protein Coding gene. Diseases associated with C11orf95 include Rela Fusion-Positive Ependymoma and Ependymoma.

Additional gene information for C11orf95 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf95 Gene

Genomics for C11orf95 Gene

GeneHancer (GH) Regulatory Elements for C11orf95 Gene

Promoters and enhancers for C11orf95 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064183 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.4 -417.0 -417026 5.2 E2F8 SIN3A ZBTB40 SP1 CTCF MLX RBPJ SMARCE1 POLR2A CEBPZ STIP1 lnc-STIP1-1 lnc-MACROD1-1 SF1 IMMP1LP1 KCNK4 PLCB3 TRPT1 ZFPL1 ENSG00000257086
GH11J064267 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -501.9 -501925 7.2 E2F8 GTF3C2 SIN3A ZBTB40 SP1 CTCF SIX5 FOXA1 MLX RBPJ GPR137 SF1 POLA2 ZFPL1 PLCB3 ENSG00000257086 SYVN1 KCNK4 IMMP1LP1 NAALADL1
GH11J064643 Promoter/Enhancer 1.1 Ensembl ENCODE dbSUPER 10.7 -874.0 -874035 2.4 ZNF148 GLIS2 CREB1 POLR2A MNT EZH2 ZNF248 ZBTB17 ZFHX2 ZNF366 C11orf95 NRXN2 ENSG00000237410 lnc-RASGRP2-2
GH11J063693 Enhancer 0.3 Ensembl 10.3 +73.9 73874 2.6 ZNF585B ZNF10 SPINDOC ATL3 ENSG00000256789 C11orf95 RF00017-937 RTN3
GH11J063895 Enhancer 0.5 dbSUPER 4.9 -128.8 -128750 3.5 ZNF680 MNT NFIC BHLHE40 REST MARK2 NAA40 C11orf95 PLAAT3 HG983614 TRR-CCT9-1 piR-46715 RF00017-938
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf95 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C11orf95 Gene

Genomic Locations for C11orf95 Gene
8,884 bases
Minus strand
8,750 bases
Minus strand

Genomic View for C11orf95 Gene

Genes around C11orf95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf95 Gene

Proteins for C11orf95 Gene

  • Protein details for C11orf95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf95
    Protein Accession:
    Secondary Accessions:
    • A6NLS7
    • Q3C1V4

    Protein attributes for C11orf95 Gene

    678 amino acids
    Molecular mass:
    73197 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for C11orf95 Gene

Post-translational modifications for C11orf95 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf95 Gene

No data available for DME Specific Peptides for C11orf95 Gene

Domains & Families for C11orf95 Gene

Gene Families for C11orf95 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for C11orf95 Gene

genes like me logo Genes that share domains with C11orf95: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf95 Gene

Function for C11orf95 Gene

Gene Ontology (GO) - Molecular Function for C11orf95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with C11orf95: view

Phenotypes for C11orf95 Gene

genes like me logo Genes that share phenotypes with C11orf95: view

Human Phenotype Ontology for C11orf95 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for C11orf95 Gene

miRTarBase miRNAs that target C11orf95

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf95 Gene

Localization for C11orf95 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf95 gene
Compartment Confidence
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf95 Gene

Pathways & Interactions for C11orf95 Gene

PathCards logo

SuperPathways for C11orf95 Gene

No Data Available

Interacting Proteins for C11orf95 Gene

Gene Ontology (GO) - Biological Process for C11orf95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IBA 21873635
genes like me logo Genes that share ontologies with C11orf95: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf95 Gene

Drugs & Compounds for C11orf95 Gene

No Compound Related Data Available

Transcripts for C11orf95 Gene

mRNA/cDNA for C11orf95 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf95 Gene

No ASD Table

Relevant External Links for C11orf95 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf95 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C11orf95 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf95 Gene

Protein tissue co-expression partners for C11orf95 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf95 Gene:


SOURCE GeneReport for Unigene cluster for C11orf95 Gene:

genes like me logo Genes that share expression patterns with C11orf95: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf95 Gene

Orthologs for C11orf95 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf95 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf95 32
  • 97.92 (n)
(Bos Taurus)
Mammalia C29H11orf95 32
  • 91.36 (n)
(Canis familiaris)
Mammalia C18H11orf95 32
  • 88.51 (n)
(Mus musculus)
Mammalia 2700081O15Rik 17 32
  • 88.18 (n)
(Rattus norvegicus)
Mammalia RGD1560108 32
  • 87.98 (n)
Species where no ortholog for C11orf95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf95 Gene

Gene Tree for C11orf95 (if available)
Gene Tree for C11orf95 (if available)

Paralogs for C11orf95 Gene

No data available for Paralogs for C11orf95 Gene

Variants for C11orf95 Gene

Sequence variations from dbSNP and Humsavar for C11orf95 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000232889 -- 63,761,520(-) A/G 3_prime_UTR_variant
rs1000263763 -- 63,761,228(-) T/C 3_prime_UTR_variant
rs1000419927 -- 63,767,560(-) G/A intron_variant
rs1000533666 -- 63,770,681(-) G/A/T upstream_transcript_variant
rs1000592709 -- 63,765,146(-) C/A coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf95 Gene

Variant ID Type Subtype PubMed ID
esv24244 CNV loss 19812545
esv33170 CNV gain 17666407
nsv1070464 CNV deletion 25765185
nsv1136128 CNV deletion 24896259
nsv1143684 CNV deletion 24896259
nsv555180 CNV loss 21841781
nsv832183 CNV loss 17160897
nsv975941 CNV duplication 23825009

Additional Variant Information for C11orf95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C11orf95 Gene

Disorders for C11orf95 Gene

MalaCards: The human disease database

(6) MalaCards diseases for C11orf95 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rela fusion-positive ependymoma
  • supratentorial c11orf95-rela fused ependymoma
  • epithelial ependymoma
chondroid lipoma
pediatric supratentorial ependymoma
  • childhood supratentorial ependymoma
supratentorial cancer
  • brain neoplasm, supratentorial
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving MRTFB is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MRTFB produces a C11orf95-MRTFB fusion protein (PubMed:20607705). {ECO:0000269 PubMed:20607705}.
  • Note=A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269 PubMed:24553141}.

Additional Disease Information for C11orf95

genes like me logo Genes that share disorders with C11orf95: view

No data available for Genatlas for C11orf95 Gene

Publications for C11orf95 Gene

  1. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. (PMID: 20607705) Huang D … Bridge JA (Genes, chromosomes & cancer 2010) 2 3 4 56
  2. C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma. (PMID: 24553141) Parker M … Gilbertson RJ (Nature 2014) 3 4 56
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 56
  4. Biology and management of ependymomas. (PMID: 27022130) Wu J … Gilbert MR (Neuro-oncology 2016) 3 56
  5. C11orf95-RELA fusion present in a primary intracranial extra-axial ependymoma: Report of a case with literature review. (PMID: 27121356) Nambirajan A … Garg A (Neuropathology : official journal of the Japanese Society of Neuropathology 2016) 3 56

Products for C11orf95 Gene

Sources for C11orf95 Gene