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Aliases for C11orf88 Gene

Aliases for C11orf88 Gene

  • Chromosome 11 Open Reading Frame 88 2 3 5
  • Hypothetical Gene Supported By BC039505 2

External Ids for C11orf88 Gene

Previous GeneCards Identifiers for C11orf88 Gene

  • GC11P110903
  • GC11P110904
  • GC11P110907
  • GC11P111386
  • GC11P107309
  • GC11P111387
  • GC11P111392
  • GC11P111398
  • GC11P111404
  • GC11P111515
  • GC11P111518
  • GC11P111521
  • GC11P111524
  • GC11P111527
  • GC11P111530
  • GC11P111533

Summaries for C11orf88 Gene

GeneCards Summary for C11orf88 Gene

C11orf88 (Chromosome 11 Open Reading Frame 88) is a Protein Coding gene.

Additional gene information for C11orf88 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf88 Gene

Genomics for C11orf88 Gene

GeneHancer (GH) Regulatory Elements for C11orf88 Gene

Promoters and enhancers for C11orf88 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I111512 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 -1.6 -1635 1.5 ZNF148 CTCF ZNF335 GLIS2 POLR2A ZBTB26 EZH2 BTG4 C11orf88 GC11P111537 GC11P111538 GC11P111539 GC11P111544 GC11P111545 GC11P111546 MIR34B MIR34C
GH11I111514 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 555.5 -0.1 -55 0.9 CTCF ELF3 PKNOX1 RFX1 SIN3A BMI1 ZNF148 POLR2A PRDM10 C11orf88 BTG4 GC11P111537 GC11P111538 GC11P111539 GC11P111544 GC11P111545 GC11P111546 MIR34B MIR34C
GH11I111764 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 8.8 +251.2 251231 3.3 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 POLR2B GLIS2 RUNX3 ZNF202 PPP2R1B ALG9 NKAPD1 SIK2 ENSG00000255334 PIH1D2 LAYN BTG4 C11orf88 MIR34B
GH11I111375 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 -136.3 -136298 5.1 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ZNF143 POU2AF1 COLCA1 COLCA2 LOC644277 BTG4 C11orf88 MIR34B MIR34C RNU2-60P MIR4491
GH11I111697 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +184.0 183977 2.6 ATF1 PKNOX1 ARNT NCOA2 CHAMP1 TCF12 SMARCA5 ZEB2 ZNF592 MBD2 PPP2R1B NKAPD1 BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf88 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf88 gene promoter:

Genomic Locations for C11orf88 Gene

Genomic Locations for C11orf88 Gene
chr11:111,514,785-111,537,031
(GRCh38/hg38)
Size:
22,247 bases
Orientation:
Plus strand
chr11:111,385,510-111,407,756
(GRCh37/hg19)

Genomic View for C11orf88 Gene

Genes around C11orf88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf88 Gene

Proteins for C11orf88 Gene

  • Protein details for C11orf88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI97-CK088_HUMAN
    Recommended name:
    UPF0722 protein C11orf88
    Protein Accession:
    Q6PI97
    Secondary Accessions:
    • E9PAN0
    • Q6ZRL3

    Protein attributes for C11orf88 Gene

    Size:
    169 amino acids
    Molecular mass:
    19340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39505.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C11orf88 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf88 Gene

Post-translational modifications for C11orf88 Gene

No Post-translational modifications

Other Protein References for C11orf88 Gene

No data available for DME Specific Peptides for C11orf88 Gene

Domains & Families for C11orf88 Gene

Gene Families for C11orf88 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf88 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PI97

UniProtKB/Swiss-Prot:

CK088_HUMAN :
  • Belongs to the UPF0722 family.
Family:
  • Belongs to the UPF0722 family.
genes like me logo Genes that share domains with C11orf88: view

Function for C11orf88 Gene

Phenotypes From GWAS Catalog for C11orf88 Gene

genes like me logo Genes that share phenotypes with C11orf88: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf88 Gene

Localization for C11orf88 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf88 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf88 Gene

Pathways & Interactions for C11orf88 Gene

SuperPathways for C11orf88 Gene

No Data Available

Interacting Proteins for C11orf88 Gene

Gene Ontology (GO) - Biological Process for C11orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048741 NOT skeletal muscle fiber development IBA --
genes like me logo Genes that share ontologies with C11orf88: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf88 Gene

Drugs & Compounds for C11orf88 Gene

No Compound Related Data Available

Transcripts for C11orf88 Gene

mRNA/cDNA for C11orf88 Gene

Unigene Clusters for C11orf88 Gene

Chromosome 11 open reading frame 88:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf88 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for C11orf88 Gene

GeneLoc Exon Structure for
C11orf88
ECgene alternative splicing isoforms for
C11orf88

Expression for C11orf88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf88 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf88 Gene

This gene is overexpressed in Testis (x11.3), Cervix - Endocervix (x6.9), Fallopian Tube (x6.2), Brain - Caudate (basal ganglia) (x6.0), and Brain - Hypothalamus (x5.5).

Protein differential expression in normal tissues from HIPED for C11orf88 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf88 Gene



Protein tissue co-expression partners for C11orf88 Gene

NURSA nuclear receptor signaling pathways regulating expression of C11orf88 Gene:

C11orf88

SOURCE GeneReport for Unigene cluster for C11orf88 Gene:

Hs.411600
genes like me logo Genes that share expression patterns with C11orf88: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf88 Gene

Orthologs for C11orf88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf88 33
  • 98.81 (n)
C11orf88 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf88 33
  • 80.26 (n)
C11orf88 34
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf88 33
  • 78.44 (n)
C11orf88 34
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4833427G06Rik 33 16 34
  • 76.79 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359479 33
  • 74.27 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf88 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11orf88 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C5H11orf88 34
  • 38 (a)
OneToOne
Species where no ortholog for C11orf88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf88 Gene

ENSEMBL:
Gene Tree for C11orf88 (if available)
TreeFam:
Gene Tree for C11orf88 (if available)

Paralogs for C11orf88 Gene

No data available for Paralogs for C11orf88 Gene

Variants for C11orf88 Gene

Sequence variations from dbSNP and Humsavar for C11orf88 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000235785 -- 111,518,010(+) T/C intron_variant
rs1000435883 -- 111,518,384(+) T/C intron_variant
rs1000570043 -- 111,516,302(+) A/G intron_variant
rs1000769142 -- 111,516,584(+) G/C/T intron_variant
rs1001039203 -- 111,530,494(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf88 Gene

Variant ID Type Subtype PubMed ID
nsv976515 CNV deletion 23825009
nsv832268 CNV loss 17160897
nsv1119912 CNV deletion 24896259

Variation tolerance for C11orf88 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf88 Gene

Disorders for C11orf88 Gene

Additional Disease Information for C11orf88

No disorders were found for C11orf88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf88 Gene

Publications for C11orf88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for C11orf88 Gene

Sources for C11orf88 Gene

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