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Aliases for C11orf86 Gene

Aliases for C11orf86 Gene

  • Chromosome 11 Open Reading Frame 86 2 3 5

External Ids for C11orf86 Gene

Previous GeneCards Identifiers for C11orf86 Gene

  • GC11P066504
  • GC11P066742
  • GC11P063070

Summaries for C11orf86 Gene

GeneCards Summary for C11orf86 Gene

C11orf86 (Chromosome 11 Open Reading Frame 86) is a Protein Coding gene.

Additional gene information for C11orf86 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf86 Gene

Genomics for C11orf86 Gene

GeneHancer (GH) Regulatory Elements for C11orf86 Gene

Promoters and enhancers for C11orf86 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I066973 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.2 -248 3.1 ARID4B SIN3A RAD21 ARID2 ZNF143 RCOR1 ZNF654 NCOA1 CEBPB REST C11orf86 LOC105369352 EIF1AD RBM14 MRPL11 ENSG00000258297 DPP3 SPTBN2 PC
GH11I066903 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.9 -68.6 -68644 5.6 FOXA2 ARID4B DMAP1 YY1 FOS RXRA SP5 NFYC REST ZNF623 PC GC11M066908 GC11M066909 C11orf80 RHOD ACTN3 CTSF RIN1 C11orf86 LRFN4
GH11I066965 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -6.2 -6225 6.8 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS DEK CLCF1 RAD9A PC RNU7-23P CTSF SPTBN2 GRK2 KDM2A POLD4 C11orf86
GH11I066981 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 +6.9 6907 1.2 NFIB RAD21 RFX5 GTF3C2 ZNF366 SCRT2 RCOR1 FOS RUNX3 ZNF362 C11orf86 SYT12
GH11I066984 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +8.9 8924 0.4 PKNOX1 ESRRA NFIB SIN3A ZKSCAN1 ZFHX2 CTBP1 EGR1 RCOR1 EGR2 C11orf86 SYT12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf86 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf86 gene promoter:

Genomic Locations for C11orf86 Gene

Genomic Locations for C11orf86 Gene
chr11:66,975,277-66,977,008
(GRCh38/hg38)
Size:
1,732 bases
Orientation:
Plus strand
chr11:66,742,748-66,744,479
(GRCh37/hg19)

Genomic View for C11orf86 Gene

Genes around C11orf86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf86 Gene

Proteins for C11orf86 Gene

  • Protein details for C11orf86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJI1-CK086_HUMAN
    Recommended name:
    Uncharacterized protein C11orf86
    Protein Accession:
    A6NJI1

    Protein attributes for C11orf86 Gene

    Size:
    115 amino acids
    Molecular mass:
    13172 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf86 Gene

Post-translational modifications for C11orf86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf86 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C11orf86 Gene

Domains & Families for C11orf86 Gene

Gene Families for C11orf86 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf86 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf86: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf86 Gene

Function for C11orf86 Gene

Phenotypes for C11orf86 Gene

genes like me logo Genes that share phenotypes with C11orf86: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf86 Gene

Localization for C11orf86 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf86 gene
Compartment Confidence
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf86 Gene

Pathways & Interactions for C11orf86 Gene

SuperPathways for C11orf86 Gene

No Data Available

Interacting Proteins for C11orf86 Gene

Gene Ontology (GO) - Biological Process for C11orf86 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf86 Gene

Drugs & Compounds for C11orf86 Gene

No Compound Related Data Available

Transcripts for C11orf86 Gene

mRNA/cDNA for C11orf86 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf86 Gene

Chromosome 11 open reading frame 86:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf86 Gene

ExUns: 1a · 1b ^ 2a · 2b
SP1:
SP2:

Relevant External Links for C11orf86 Gene

GeneLoc Exon Structure for
C11orf86
ECgene alternative splicing isoforms for
C11orf86

Expression for C11orf86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf86 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf86 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x33.8) and Colon - Transverse (x12.3).

NURSA nuclear receptor signaling pathways regulating expression of C11orf86 Gene:

C11orf86

SOURCE GeneReport for Unigene cluster for C11orf86 Gene:

Hs.232604
genes like me logo Genes that share expression patterns with C11orf86: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf86 Gene

Orthologs for C11orf86 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf86 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf86 33
  • 100 (n)
C11orf86 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C29H11orf86 33 34
  • 81.12 (n)
mouse
(Mus musculus)
Mammalia 2010003K11Rik 33 16 34
  • 80.12 (n)
dog
(Canis familiaris)
Mammalia C18H11orf86 33
  • 79.94 (n)
C11ORF86 34
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC689065 33
  • 78.95 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf86 34
  • 53 (a)
OneToOne
Species where no ortholog for C11orf86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf86 Gene

ENSEMBL:
Gene Tree for C11orf86 (if available)
TreeFam:
Gene Tree for C11orf86 (if available)

Paralogs for C11orf86 Gene

No data available for Paralogs for C11orf86 Gene

Variants for C11orf86 Gene

Sequence variations from dbSNP and Humsavar for C11orf86 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000205986 -- 66,973,902(+) A/C upstream_transcript_variant
rs1000403575 -- 66,974,311(+) A/G upstream_transcript_variant
rs1000689050 -- 66,975,470(+) A/G/T coding_sequence_variant, synonymous_variant
rs1001035745 -- 66,976,712(+) C/T 3_prime_UTR_variant
rs1001207573 -- 66,975,264(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf86 Gene

Variant ID Type Subtype PubMed ID
nsv555226 CNV gain 21841781
nsv832194 CNV gain+loss 17160897

Variation tolerance for C11orf86 Gene

Gene Damage Index Score: 1.69; 32.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf86

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf86 Gene

Disorders for C11orf86 Gene

Additional Disease Information for C11orf86

No disorders were found for C11orf86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf86 Gene

Publications for C11orf86 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for C11orf86 Gene

Sources for C11orf86 Gene

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