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Aliases for C11orf74 Gene

Aliases for C11orf74 Gene

  • Chromosome 11 Open Reading Frame 74 2 3 5
  • Uncharacterized Protein C11orf74 3
  • Protein HEPIS 4
  • HEPIS 3
  • NWC 3

External Ids for C11orf74 Gene

Previous GeneCards Identifiers for C11orf74 Gene

  • GC11P036318

Summaries for C11orf74 Gene

Entrez Gene Summary for C11orf74 Gene

  • This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for C11orf74 Gene

C11orf74 (Chromosome 11 Open Reading Frame 74) is a Protein Coding gene.

Additional gene information for C11orf74 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf74 Gene

Genomics for C11orf74 Gene

GeneHancer (GH) Regulatory Elements for C11orf74 Gene

Promoters and enhancers for C11orf74 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I036593 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.6 581 1.9 FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 C11orf74 TRAF6 PRR5L RAG2
GH11I036564 Enhancer 1 Ensembl ENCODE dbSUPER 12.1 -29.5 -29522 0.6 CTCF ZNF654 SOX6 E2F5 MAFG REST RAD21 FOSL1 DIDO1 ADNP C11orf74 RAG2 PRR5L GC11P036555 RAG1
GH11I036626 Enhancer 0.9 ENCODE dbSUPER 11.8 +33.5 33469 2.4 PKNOX1 FEZF1 ZIC2 CTBP1 SCRT2 RCOR1 CHD2 TCF7L2 ZBTB20 SCRT1 RAG2 C11orf74 TRAF6 RAG1 GC11M036597 GC11M036644
GH11I036541 Enhancer 1 Ensembl ENCODE 10.2 -53.0 -53028 0.4 MEIS2 CTCF TFAP4 PKNOX1 USF1 ATF1 SAP130 SIN3A EBF1 BATF TRAF6 RAG1 C11orf74 RAG2 GC11M036546
GH11I036567 Promoter/Enhancer 0.7 EPDnew dbSUPER 12 -26.2 -26236 0.1 RAG1 C11orf74 RAG2 TRAF6 GC11P036555
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf74 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf74 gene promoter:

Genomic Locations for C11orf74 Gene

Genomic Locations for C11orf74 Gene
65,063 bases
Plus strand

Genomic View for C11orf74 Gene

Genes around C11orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf74 Gene

Proteins for C11orf74 Gene

  • Protein details for C11orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf74
    Protein Accession:
    Secondary Accessions:
    • D3DR18
    • Q96DD6

    Protein attributes for C11orf74 Gene

    221 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf74 Gene


neXtProt entry for C11orf74 Gene

Post-translational modifications for C11orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf74 Gene

Domains & Families for C11orf74 Gene

Gene Families for C11orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf74 Gene


Suggested Antigen Peptide Sequences for C11orf74 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf74: view

No data available for UniProtKB/Swiss-Prot for C11orf74 Gene

Function for C11orf74 Gene

Phenotypes From GWAS Catalog for C11orf74 Gene

genes like me logo Genes that share phenotypes with C11orf74: view

Animal Model Products

miRNA for C11orf74 Gene

miRTarBase miRNAs that target C11orf74

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf74 Gene

Localization for C11orf74 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf74 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with C11orf74: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf74 Gene

Pathways & Interactions for C11orf74 Gene

SuperPathways for C11orf74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf74 Gene

Drugs & Compounds for C11orf74 Gene

No Compound Related Data Available

Transcripts for C11orf74 Gene

Unigene Clusters for C11orf74 Gene

Chromosome 11 open reading frame 74:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf74 Gene

No ASD Table

Relevant External Links for C11orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf74 Gene

Protein differential expression in normal tissues from HIPED for C11orf74 Gene

This gene is overexpressed in Fetal gut (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C11orf74 Gene

Protein tissue co-expression partners for C11orf74 Gene

NURSA nuclear receptor signaling pathways regulating expression of C11orf74 Gene:


SOURCE GeneReport for Unigene cluster for C11orf74 Gene:


Evidence on tissue expression from TISSUES for C11orf74 Gene

  • Pancreas(4.2)
  • Heart(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with C11orf74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf74 Gene

Orthologs for C11orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf74 33
  • 98.34 (n)
C11orf74 34
  • 96 (a)
(Bos Taurus)
Mammalia C15H11orf74 33
  • 80.03 (n)
C15H11ORF74 34
  • 61 (a)
(Canis familiaris)
Mammalia C18H11orf74 33
  • 79.76 (n)
C11orf74 34
  • 61 (a)
(Mus musculus)
Mammalia B230118H07Rik 33 16 34
  • 77.29 (n)
(Rattus norvegicus)
Mammalia RGD1309730 33
  • 76.19 (n)
(Ornithorhynchus anatinus)
Mammalia C11orf74 34
  • 45 (a)
(Monodelphis domestica)
Mammalia C11orf74 34
  • 37 (a)
(Gallus gallus)
Aves C11orf74 34
  • 24 (a)
(Danio rerio)
Actinopterygii C25H11orf74 34
  • 23 (a)
Species where no ortholog for C11orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf74 Gene

Gene Tree for C11orf74 (if available)
Gene Tree for C11orf74 (if available)

Paralogs for C11orf74 Gene Pseudogenes for C11orf74 Gene

genes like me logo Genes that share paralogs with C11orf74: view

No data available for Paralogs for C11orf74 Gene

Variants for C11orf74 Gene

Sequence variations from dbSNP and Humsavar for C11orf74 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs10836573 benign, Severe Combined Immune Deficiency, Histiocytic medullary reticulosis 36,592,257(+) T/C upstream_transcript_variant
rs113343318 uncertain-significance, Histiocytic medullary reticulosis, Severe Combined Immune Deficiency 36,592,358(+) A/G upstream_transcript_variant
rs121917894 pathogenic, Severe combined immunodeficiency, B cell-negative, Histiocytic medullary reticulosis 36,593,483(+) C/A/T upstream_transcript_variant
rs121917895 pathogenic, Histiocytic medullary reticulosis 36,594,046(+) G/A/C upstream_transcript_variant
rs121917896 pathogenic, Histiocytic medullary reticulosis 36,593,315(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf74 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV duplication 17116639
esv2674800 CNV deletion 23128226
esv27238 CNV loss 19812545
esv29188 CNV loss 19812545
esv3625963 CNV loss 21293372
nsv1042014 CNV loss 25217958
nsv467791 CNV gain 19166990
nsv467792 CNV gain 19166990
nsv518415 CNV loss 19592680
nsv554003 CNV gain 21841781
nsv554004 CNV gain 21841781
nsv554005 CNV gain 21841781
nsv554006 CNV loss 21841781
nsv832123 CNV gain 17160897
nsv976512 CNV deletion 23825009

Variation tolerance for C11orf74 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf74 Gene

Disorders for C11orf74 Gene

Additional Disease Information for C11orf74

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C11orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf74 Gene

Publications for C11orf74 Gene

  1. Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus. (PMID: 18433331) Hong M … Li Q (Viral immunology 2008) 2 3 22 58
  2. Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice. (PMID: 26703212) Kasztura M … Kisielow P (Archivum immunologiae et therapiae experimentalis 2016) 2 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 2 3 58
  4. Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation. (PMID: 15971274) Cebrat M … Kisielow P (European journal of immunology 2005) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C11orf74 Gene

Sources for C11orf74 Gene

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