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Aliases for C11orf65 Gene

Aliases for C11orf65 Gene

  • Chromosome 11 Open Reading Frame 65 2 3 5
  • Uncharacterized Protein C11orf65 3 4

External Ids for C11orf65 Gene

Previous GeneCards Identifiers for C11orf65 Gene

  • GC11M107708
  • GC11M108179
  • GC11M104179

Summaries for C11orf65 Gene

GeneCards Summary for C11orf65 Gene

C11orf65 (Chromosome 11 Open Reading Frame 65) is a Protein Coding gene. Diseases associated with C11orf65 include T-Cell Prolymphocytic Leukemia.

Additional gene information for C11orf65 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf65 Gene

Genomics for C11orf65 Gene

GeneHancer (GH) Regulatory Elements for C11orf65 Gene

Promoters and enhancers for C11orf65 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J108465 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 600.7 +0.3 261 2.7 SP1 CC2D1A ZFX NKRF POLR2A MLLT1 CEBPG GTF2F1 CSDE1 ZNF687 C11orf65 POGLUT3 DDX10 ACAT1 PIR35860
GH11J108219 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 +241.7 241686 12.2 SP1 CC2D1A ELF3 CTCF MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 NPAT ATM ACAT1 DDX10 POGLUT3 CWF19L2 ENSG00000255467 C11orf65 ENSG00000206967 GC11M108232
GH11J108233 Enhancer 1.1 ENCODE dbSUPER 7.9 +228.9 228942 11.1 ZNF384 ZNF687 MAFK CREM ZNF644 IKZF1 CREB1 IKZF2 GATAD2A RXRB ACAT1 ATM ENSG00000255467 DDX10 C11orf65 POGLUT3 ENSG00000206967 GC11M108232 PIR35860
GH11J108340 Enhancer 1.1 Ensembl ENCODE 4.1 +127.4 127410 3 CBFA2T2 MLLT1 CEBPG ZSCAN21 NCOA3 TFE3 TRIM24 SP7 PRDM1 SMARCA4 ACAT1 C11orf65 PIR35860 ENSG00000206967 GC11M108232 ATM
GH11J108958 Enhancer 1.1 Ensembl ENCODE dbSUPER 4 -492.5 -492454 4 POLR2A PKNOX1 CEBPA JUN JUND RUNX3 FOS FOSL1 NR2F1 BCOR C11orf65 ENSG00000203334 RNU6-654P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf65 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf65 gene promoter:
  • AML1a
  • C/EBPbeta
  • E4BP4
  • HOXA9
  • HOXA9B
  • Pax-4a
  • Pbx1a
  • RSRFC4
  • SEF-1 (1)
  • Sox9

Genomic Locations for C11orf65 Gene

Genomic Locations for C11orf65 Gene
chr11:108,308,519-108,467,547
(GRCh38/hg38)
Size:
159,029 bases
Orientation:
Minus strand
chr11:108,179,246-108,338,258
(GRCh37/hg19)
Size:
159,013 bases
Orientation:
Minus strand

Genomic View for C11orf65 Gene

Genes around C11orf65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf65 Gene

Proteins for C11orf65 Gene

  • Protein details for C11orf65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCR3-CK065_HUMAN
    Recommended name:
    Uncharacterized protein C11orf65
    Protein Accession:
    Q8NCR3
    Secondary Accessions:
    • B4DZU4
    • Q6PCA8

    Protein attributes for C11orf65 Gene

    Size:
    313 amino acids
    Molecular mass:
    36720 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf65 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf65 Gene

Post-translational modifications for C11orf65 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf65 Gene

Domains & Families for C11orf65 Gene

Gene Families for C11orf65 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf65 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf65 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59803 (B4DZU4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf65: view

No data available for UniProtKB/Swiss-Prot for C11orf65 Gene

Function for C11orf65 Gene

Phenotypes From GWAS Catalog for C11orf65 Gene

Gene Ontology (GO) - Molecular Function for C11orf65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C11orf65: view
genes like me logo Genes that share phenotypes with C11orf65: view

Animal Model Products

CRISPR Products

miRNA for C11orf65 Gene

miRTarBase miRNAs that target C11orf65

Clone Products

  • Applied Biological Materials (abm): Clones for C11orf65 - Now 50% OFF >
  • * C11orf65 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C11orf65 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf65 Gene

Localization for C11orf65 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf65 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf65 Gene

Pathways & Interactions for C11orf65 Gene

PathCards logo

SuperPathways for C11orf65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf65 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf65 Gene

Drugs & Compounds for C11orf65 Gene

(1) Drugs for C11orf65 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma AMP-activated protein kinase (AMPK) activator 2069
genes like me logo Genes that share compounds with C11orf65: view

Transcripts for C11orf65 Gene

mRNA/cDNA for C11orf65 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for C11orf65 Gene

Chromosome 11 open reading frame 65:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for C11orf65 - Now 50% OFF >
  • * C11orf65 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C11orf65 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf65 Gene

No ASD Table

Relevant External Links for C11orf65 Gene

GeneLoc Exon Structure for
C11orf65
ECgene alternative splicing isoforms for
C11orf65

Expression for C11orf65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf65 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf65 Gene

This gene is overexpressed in Testis (x22.8).

NURSA nuclear receptor signaling pathways regulating expression of C11orf65 Gene:

C11orf65

SOURCE GeneReport for Unigene cluster for C11orf65 Gene:

Hs.653180
genes like me logo Genes that share expression patterns with C11orf65: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf65 Gene

Orthologs for C11orf65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11orf65 35
  • 100 (a)
OneToOne
C11H11orf65 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia C5H11orf65 34
  • 86.11 (n)
C11orf65 35
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf65 34
  • 85.04 (n)
mouse
(Mus musculus)
Mammalia 4930550C14Rik 34 35 17
  • 78.22 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311251 34
  • 77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf65 35
  • 53 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf65 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf65 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490935 34
  • 59.25 (n)
zebrafish
(Danio rerio)
Actinopterygii gb:co360592 34
  • 57.12 (n)
C24H11orf65 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3681 35
  • 51 (a)
OneToOne
Cin.13913 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13913 34
Species where no ortholog for C11orf65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf65 Gene

ENSEMBL:
Gene Tree for C11orf65 (if available)
TreeFam:
Gene Tree for C11orf65 (if available)

Paralogs for C11orf65 Gene

Pseudogenes.org Pseudogenes for C11orf65 Gene

genes like me logo Genes that share paralogs with C11orf65: view

No data available for Paralogs for C11orf65 Gene

Variants for C11orf65 Gene

Sequence variations from dbSNP and Humsavar for C11orf65 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1013290424 uncertain-significance, Ataxia-telangiectasia syndrome 108,353,879(-) A/C genic_downstream_transcript_variant, intron_variant
rs1018140779 likely-pathogenic, uncertain-significance, Ataxia-telangiectasia syndrome, not specified, Hereditary cancer-predisposing syndrome 108,329,097(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1026199027 likely-benign, Hereditary cancer-predisposing syndrome 108,327,626(-) T/C genic_downstream_transcript_variant, intron_variant
rs1027667991 likely-benign, not specified, Hereditary cancer-predisposing syndrome 108,354,891(-) G/A genic_downstream_transcript_variant, intron_variant
rs1027903529 likely-benign, Hereditary cancer-predisposing syndrome 108,347,340(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf65 Gene

Variant ID Type Subtype PubMed ID
dgv2182n54 CNV gain 21841781
esv1612880 CNV insertion 17803354
esv21753 CNV gain 19812545
esv3627675 CNV gain 21293372
esv3627676 CNV loss 21293372
esv3627677 CNV loss 21293372
esv3892100 CNV loss 25118596
nsv832262 CNV loss 17160897
nsv832263 CNV gain 17160897

Variation tolerance for C11orf65 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf65
Human Gene Mutation Database (HGMD)
C11orf65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf65 Gene

Disorders for C11orf65 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C11orf65 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
t-cell prolymphocytic leukemia
  • leukemia, t-cell, chronic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C11orf65

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C11orf65: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf65 Gene

Publications for C11orf65 Gene

  1. Does metformin work for everyone? A genome-wide association study for metformin response. (PMID: 21845381) Florez JC (Current diabetes reports 2011) 3 45 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 45 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3 58

Products for C11orf65 Gene

Sources for C11orf65 Gene

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