Aliases for C11orf58 Gene

Aliases for C11orf58 Gene

  • Chromosome 11 Open Reading Frame 58 2 3 5
  • Small Acidic Protein 2 3 4
  • SMAP 2 3
  • IMAGE145052 3
  • C11orf58 5

External Ids for C11orf58 Gene

Previous GeneCards Identifiers for C11orf58 Gene

  • GC11P016717
  • GC11P016444

Summaries for C11orf58 Gene

GeneCards Summary for C11orf58 Gene

C11orf58 (Chromosome 11 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C11orf58 include Ataxia, Sensory, 1, Autosomal Dominant and Achalasia-Addisonianism-Alacrima Syndrome.

Gene Wiki entry for C11orf58 Gene

Additional gene information for C11orf58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf58 Gene

Genomics for C11orf58 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C11orf58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J016737 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.1 +126.6 126569 4.6 ZSCAN16 CHD2 TBP MXD4 SIX5 NR2C1 MNT DEK SMAD5 ETS1 HSALNG0082896 HSALNG0082897 SOX6 lnc-SOX6-3 C11orf58 KCNC1 ENSG00000260196 PLEKHA7
GH11J016611 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.4 365 3 DEK ZNF217 CTCF ZEB1 ZIC2 REST RXRA SMC3 RAD21 CTBP1 C11orf58 LOC105376571 piR-54414 SOX6 lnc-SOX6-3
GH11J016613 Promoter 0.6 Ensembl 250.7 -1.6 -1631 0.6 CBX8 ZBTB33 EZH2 C11orf58 LOC105376571 RN7SL188P SOX6 lnc-SOX6-3
GH11J017206 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.5 +595.3 595300 4.9 TBP ZBTB10 CEBPA MNT IKZF1 SMAD5 ETS1 MBD2 ZNF217 POLR2A PIK3C2A NUCB2 lnc-PIK3C2A-1 lnc-NCR3LG1-4 lnc-NUCB2-4 SAAL1 SNORD14A OR7E14P SNORD14B RPS13
GH11J015965 Promoter/Enhancer 2.1 UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 -644.8 -644819 6.4 TBP BCL11A IKZF1 SMAD5 IRF2 BHLHE40 ARNT ZNF395 GTF2E2 VEZF1 MIR6073 lnc-PLEKHA7-8 ENSG00000254878 C11orf58 SOX6 INSC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf58 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf58

Top Transcription factor binding sites by QIAGEN in the C11orf58 gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • Ik-1
  • Lmo2
  • MEF-2A
  • Nkx2-5
  • Roaz
  • Sox5
  • SRY

Genomic Locations for C11orf58 Gene

Latest Assembly
145,209 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
19,694 bases
Plus strand

(GRCh37/hg19 by Ensembl)
143,750 bases
Plus strand

Genomic View for C11orf58 Gene

Genes around C11orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf58 Gene

Proteins for C11orf58 Gene

  • Protein details for C11orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small acidic protein
    Protein Accession:
    Secondary Accessions:
    • B2RD28

    Protein attributes for C11orf58 Gene

    183 amino acids
    Molecular mass:
    20333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf58 Gene

Post-translational modifications for C11orf58 Gene

  • Ubiquitination at Lys62, Lys75, Lys91, Lys174, and Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf58 Gene

No data available for DME Specific Peptides for C11orf58 Gene

Domains & Families for C11orf58 Gene

Gene Families for C11orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf58 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMAP family.
  • Belongs to the SMAP family.
genes like me logo Genes that share domains with C11orf58: view

No data available for Suggested Antigen Peptide Sequences for C11orf58 Gene

Function for C11orf58 Gene

Phenotypes From GWAS Catalog for C11orf58 Gene

Gene Ontology (GO) - Molecular Function for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C11orf58: view
genes like me logo Genes that share phenotypes with C11orf58: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf58 Gene

Localization for C11orf58 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf58 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf58 Gene

Pathways & Interactions for C11orf58 Gene

PathCards logo

SuperPathways for C11orf58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf58 Gene

Drugs & Compounds for C11orf58 Gene

(1) Drugs for C11orf58 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C11orf58: view

Transcripts for C11orf58 Gene

mRNA/cDNA for C11orf58 Gene

15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf58

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for C11orf58 Gene

GeneLoc Exon Structure for

Expression for C11orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf58 Gene

Protein differential expression in normal tissues from HIPED for C11orf58 Gene

This gene is overexpressed in Adrenal (47.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf58 Gene

Protein tissue co-expression partners for C11orf58 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf58

SOURCE GeneReport for Unigene cluster for C11orf58 Gene:


Evidence on tissue expression from TISSUES for C11orf58 Gene

  • Nervous system(4.8)
  • Lung(3.9)
  • Skin(3.8)
  • Kidney(3.7)
  • Liver(2.6)
  • Thyroid gland(2.5)
  • Muscle(2.4)
  • Heart(2.3)
  • Adrenal gland(2.3)
  • Blood(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with C11orf58: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf58 Gene

Orthologs for C11orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf58 30
  • 100 (n)
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
C21H11orf58 30
  • 93.77 (n)
-- 31
  • 90 (a)
(Bos Taurus)
Mammalia SMAP 31
  • 98 (a)
C15H11orf58 30
  • 93 (n)
(Monodelphis domestica)
Mammalia C11orf58 31
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf58 31
  • 90 (a)
(Mus musculus)
Mammalia 1110004F10Rik 30 17 31
  • 85.27 (n)
(Rattus norvegicus)
Mammalia RGD1311703 30
  • 85.27 (n)
(Gallus gallus)
Aves C5H11ORF58 30 31
  • 77 (n)
(Anolis carolinensis)
Reptilia C11orf58 31
  • 74 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c11orf58 30
  • 58.38 (n)
Str.5966 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18476 30
(Danio rerio)
Actinopterygii zgc:56106 30
  • 71.09 (n)
C18H11orf58 31
  • 55 (a)
zgc56106 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5834 30
Species where no ortholog for C11orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C11orf58 Gene

Gene Tree for C11orf58 (if available)
Gene Tree for C11orf58 (if available)

Paralogs for C11orf58 Gene

(2) SIMAP similar genes for C11orf58 Gene using alignment to 5 proteins:

  • E3W975_HUMAN
  • E9PM92_HUMAN
  • L8E8H2_HUMAN Pseudogenes for C11orf58 Gene

genes like me logo Genes that share paralogs with C11orf58: view

No data available for Paralogs for C11orf58 Gene

Variants for C11orf58 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C11orf58 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C11orf58 Gene

Variant ID Type Subtype PubMed ID
esv23566 CNV loss 19812545
esv2571561 CNV deletion 19546169
nsv553566 CNV gain 21841781

Variation tolerance for C11orf58 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf58 Gene

Disorders for C11orf58 Gene

MalaCards: The human disease database

(3) MalaCards diseases for C11orf58 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C11orf58

genes like me logo Genes that share disorders with C11orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf58 Gene

Publications for C11orf58 Gene

  1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PMID: 9263035) Gong TW … Lomax MI (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997) 2 3 4 23
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for C11orf58 Gene

Sources for C11orf58 Gene