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Aliases for C11orf58 Gene

Aliases for C11orf58 Gene

  • Chromosome 11 Open Reading Frame 58 2 3 5
  • Small Acidic Protein 2 3
  • SMAP 3 4
  • IMAGE145052 3

External Ids for C11orf58 Gene

Previous GeneCards Identifiers for C11orf58 Gene

  • GC11P016717
  • GC11P016444

Summaries for C11orf58 Gene

GeneCards Summary for C11orf58 Gene

C11orf58 (Chromosome 11 Open Reading Frame 58) is a Protein Coding gene.

Gene Wiki entry for C11orf58 Gene

Additional gene information for C11orf58 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf58 Gene

Genomics for C11orf58 Gene

GeneHancer (GH) Regulatory Elements for C11orf58 Gene

Promoters and enhancers for C11orf58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I016737 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.1 +125.9 125909 3 HDGF FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B SOX6 C11orf58 SNORD14A SNORD14B PIR48413
GH11I016612 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 +0.4 442 1.9 PKNOX1 FOXA2 RB1 ZSCAN4 ARID4B ZNF76 SIN3A ZNF2 ZNF48 RAD21 C11orf58 PIR48413 LOC105376571 SOX6
GH11I016611 Enhancer 0.4 ENCODE 550.8 -1.1 -1063 0.2 SUZ12 ZBTB33 EZH2 C11orf58 PIR48413 LOC105376571 RN7SL188P SOX6
GH11I017207 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 11.5 +595.5 595506 4.5 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B PIK3C2A GC11P017210 GC11P017211 NUCB2 OR7E14P SAAL1 SNORD14A C11orf58 RPL36AP37 RPS13
GH11I015965 Enhancer 2 UCNEbase FANTOM5 Ensembl ENCODE dbSUPER 9.6 -644.8 -644819 6.4 ATF1 ARNT NEUROD1 IRF4 YY1 POLR2B ZNF766 FOS ATF7 RUNX3 MIR6073 GC11M015966 LOC105376572 C11orf58 SOX6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf58 gene promoter:

Genomic Locations for C11orf58 Gene

Genomic Locations for C11orf58 Gene
145,223 bases
Plus strand

Genomic View for C11orf58 Gene

Genes around C11orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf58 Gene

Proteins for C11orf58 Gene

  • Protein details for C11orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small acidic protein
    Protein Accession:
    Secondary Accessions:
    • B2RD28

    Protein attributes for C11orf58 Gene

    183 amino acids
    Molecular mass:
    20333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf58 Gene

Post-translational modifications for C11orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf58 Gene

No data available for DME Specific Peptides for C11orf58 Gene

Domains & Families for C11orf58 Gene

Gene Families for C11orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf58 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMAP family.
  • Belongs to the SMAP family.
genes like me logo Genes that share domains with C11orf58: view

No data available for Suggested Antigen Peptide Sequences for C11orf58 Gene

Function for C11orf58 Gene

Phenotypes From GWAS Catalog for C11orf58 Gene

Gene Ontology (GO) - Molecular Function for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C11orf58: view

Phenotypes for C11orf58 Gene

genes like me logo Genes that share phenotypes with C11orf58: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf58 Gene

Localization for C11orf58 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf58 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf58 Gene

Pathways & Interactions for C11orf58 Gene

SuperPathways for C11orf58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf58 Gene

Drugs & Compounds for C11orf58 Gene

(1) Drugs for C11orf58 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C11orf58: view

Transcripts for C11orf58 Gene

Unigene Clusters for C11orf58 Gene

Chromosome 11 open reading frame 58:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for C11orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf58 Gene

Protein differential expression in normal tissues from HIPED for C11orf58 Gene

This gene is overexpressed in Adrenal (47.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C11orf58 Gene

Protein tissue co-expression partners for C11orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf58 Gene:


SOURCE GeneReport for Unigene cluster for C11orf58 Gene:


Evidence on tissue expression from TISSUES for C11orf58 Gene

  • Nervous system(4.7)
  • Lung(3.8)
  • Kidney(3.6)
  • Skin(3.4)
  • Thyroid gland(2.4)
  • Liver(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with C11orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf58 Gene

Orthologs for C11orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf58 33
  • 100 (n)
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
C21H11orf58 33
  • 93.77 (n)
-- 34
  • 90 (a)
(Bos Taurus)
Mammalia SMAP 34
  • 98 (a)
C15H11orf58 33
  • 93 (n)
(Monodelphis domestica)
Mammalia C11orf58 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf58 34
  • 90 (a)
(Mus musculus)
Mammalia 1110004F10Rik 33 16 34
  • 85.27 (n)
(Rattus norvegicus)
Mammalia RGD1311703 33
  • 85.27 (n)
(Gallus gallus)
Aves C5H11ORF58 33 34
  • 77 (n)
(Anolis carolinensis)
Reptilia C11orf58 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf58 33
  • 58.38 (n)
Str.5966 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.18476 33
(Danio rerio)
Actinopterygii zgc:56106 33
  • 71.09 (n)
C18H11orf58 34
  • 55 (a)
zgc56106 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5834 33
Species where no ortholog for C11orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf58 Gene

Gene Tree for C11orf58 (if available)
Gene Tree for C11orf58 (if available)

Paralogs for C11orf58 Gene

(2) SIMAP similar genes for C11orf58 Gene using alignment to 5 proteins: Pseudogenes for C11orf58 Gene

genes like me logo Genes that share paralogs with C11orf58: view

No data available for Paralogs for C11orf58 Gene

Variants for C11orf58 Gene

Sequence variations from dbSNP and Humsavar for C11orf58 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000432503 -- 16,739,699(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000486362 -- 16,739,508(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000487117 -- 16,751,641(+) GGG/GG intron_variant
rs1000550096 -- 16,747,568(+) T/A intron_variant
rs1000735703 -- 16,746,735(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf58 Gene

Variant ID Type Subtype PubMed ID
esv23566 CNV loss 19812545
esv2571561 CNV deletion 19546169
nsv553566 CNV gain 21841781

Variation tolerance for C11orf58 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf58 Gene

Disorders for C11orf58 Gene

Additional Disease Information for C11orf58

No disorders were found for C11orf58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf58 Gene

Publications for C11orf58 Gene

  1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PMID: 9263035) Gong TW … Lomax MI (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997) 2 3 4 22 58
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for C11orf58 Gene

Sources for C11orf58 Gene

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