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Aliases for C11orf54 Gene

Aliases for C11orf54 Gene

  • Chromosome 11 Open Reading Frame 54 2 3 5
  • Ester Hydrolase C11orf54 3
  • EC 3.1.-.- 4
  • PTOD012 3
  • PTD012 3

External Ids for C11orf54 Gene

Previous GeneCards Identifiers for C11orf54 Gene

  • GC11P093115
  • GC11P093474
  • GC11P089552

Summaries for C11orf54 Gene

GeneCards Summary for C11orf54 Gene

C11orf54 (Chromosome 11 Open Reading Frame 54) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for C11orf54 Gene

  • Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.

Gene Wiki entry for C11orf54 Gene

Additional gene information for C11orf54 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf54 Gene

Genomics for C11orf54 Gene

GeneHancer (GH) Regulatory Elements for C11orf54 Gene

Promoters and enhancers for C11orf54 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J093733 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 678.7 -3.3 -3256 9.9 HNRNPUL1 PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 POLR2B C11orf54 TAF1D MED17 ANKRD49 CEP295 MRE11 SNORA1 ENSG00000255445 SCARNA9 SMCO4
GH11J093743 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 714.9 +3.3 3340 3.2 FOXA2 ARID4B DMAP1 ZNF48 RARA YY1 ZNF614 MIXL1 HMG20B KLF11 C11orf54 CEP295 ENSG00000284057 PIR37895 GC11P093749 TAF1D
GH11J093761 Promoter 0.7 EPDnew 650.3 +20.4 20421 0.1 ZNF316 MAFK EMSY C11orf54 PIR59455 MED17 TAF1D ENSG00000284057
GH11J093783 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 59.5 +43.1 43139 2.6 PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 MED17 TAF1D C11orf54 SNORA1 MRE11 ANKRD49 ENSG00000255233 LOC642791 ENSG00000233536 ENSG00000254874
GH11J093746 Enhancer 0.6 ENCODE 64 +5.7 5747 1.4 SOX5 SOX13 FOXA2 RXRA BATF YY1 SP1 HNF1A HNF4A MIXL1 GC11P093749 GC11P093748 C11orf54 CEP295 PIR37895 ENSG00000284057 TAF1D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf54 gene promoter:
  • RORalpha1
  • GATA-1
  • MEF-2A
  • aMEF-2
  • MEF-2
  • POU2F1
  • POU2F1a
  • GR

Genomic Locations for C11orf54 Gene

Genomic Locations for C11orf54 Gene
23,159 bases
Plus strand
23,159 bases
Plus strand

Genomic View for C11orf54 Gene

Genes around C11orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf54 Gene

Proteins for C11orf54 Gene

  • Protein details for C11orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ester hydrolase C11orf54
    Protein Accession:
    Secondary Accessions:
    • A8K850
    • Q6FI88
    • Q6XYB0
    • Q96EI3
    • Q96IX1
    • Q9Y6B4

    Protein attributes for C11orf54 Gene

    315 amino acids
    Molecular mass:
    35117 Da
    Quaternary structure:
    • Monomer.
    • Sequence=AAH07110.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP34483.1; Type=Frameshift; Positions=125; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C11orf54 Gene

    Alternative splice isoforms for C11orf54 Gene


neXtProt entry for C11orf54 Gene

Post-translational modifications for C11orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf54 Gene

Domains & Families for C11orf54 Gene

Gene Families for C11orf54 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf54 Gene


Suggested Antigen Peptide Sequences for C11orf54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf54: view

No data available for UniProtKB/Swiss-Prot for C11orf54 Gene

Function for C11orf54 Gene

Molecular function for C11orf54 Gene

UniProtKB/Swiss-Prot Function:
Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.

Enzyme Numbers (IUBMB) for C11orf54 Gene

Gene Ontology (GO) - Molecular Function for C11orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IDA 16522806
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IDA 16522806
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with C11orf54: view

Phenotypes for C11orf54 Gene

genes like me logo Genes that share phenotypes with C11orf54: view

Animal Model Products

miRNA for C11orf54 Gene

miRTarBase miRNAs that target C11orf54

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf54 Gene

Localization for C11orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf54 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf54 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C11orf54: view

Pathways & Interactions for C11orf54 Gene

SuperPathways for C11orf54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf54 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf54 Gene

Drugs & Compounds for C11orf54 Gene

No Compound Related Data Available

Transcripts for C11orf54 Gene

Unigene Clusters for C11orf54 Gene

Chromosome 11 open reading frame 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf54 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13: - -
SP14: - - - - - -
SP15: -
SP16: - - -

ExUns: 12d

Relevant External Links for C11orf54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf54 Gene

This gene is overexpressed in Kidney - Cortex (x7.9) and Liver (x4.2).

Protein differential expression in normal tissues from HIPED for C11orf54 Gene

This gene is overexpressed in Liver, secretome (16.1) and Kidney (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf54 Gene

Protein tissue co-expression partners for C11orf54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf54 Gene:


SOURCE GeneReport for Unigene cluster for C11orf54 Gene:


Evidence on tissue expression from TISSUES for C11orf54 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Muscle(4.2)
  • Kidney(3.3)
genes like me logo Genes that share expression patterns with C11orf54: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf54 Gene

Orthologs for C11orf54 Gene

This gene was present in the common ancestor of animals.

Orthologs for C11orf54 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11orf54 34
  • 100 (a)
C11H11orf54 33
  • 99.68 (n)
(Bos Taurus)
Mammalia C29H11orf54 33
  • 91.11 (n)
C11orf54 34
  • 77 (a)
(Canis familiaris)
Mammalia C11orf54 34
  • 91 (a)
C21H11orf54 33
  • 90.48 (n)
(Mus musculus)
Mammalia 4931406C07Rik 16 34 33
  • 85.61 (n)
(Rattus norvegicus)
Mammalia RGD1309534 33
  • 82.43 (n)
(Monodelphis domestica)
Mammalia C11orf54 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf54 34
  • 64 (a)
(Gallus gallus)
Aves C1H11ORF54 34 33
  • 73.31 (n)
(Anolis carolinensis)
Reptilia C11orf54 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf54 33
  • 67.53 (n)
Str.17657 33
(Danio rerio)
Actinopterygii zgc:85789 33
  • 64.09 (n)
C24H11orf54 34
  • 48 (a)
wufc54a08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9818 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006729 33
  • 49.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9119 34 33
  • 48.97 (n)
CG32335 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea C24B5.4 34 33
  • 52.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for C11orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C11orf54 Gene

Gene Tree for C11orf54 (if available)
Gene Tree for C11orf54 (if available)

Paralogs for C11orf54 Gene

No data available for Paralogs for C11orf54 Gene

Variants for C11orf54 Gene

Sequence variations from dbSNP and Humsavar for C11orf54 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000002165 -- 93,741,772(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000096681 -- 93,742,040(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000181338 -- 93,750,637(+) G/A intron_variant
rs1000182201 -- 93,765,710(+) A/G downstream_transcript_variant
rs1000291845 -- 93,745,995(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf54 Gene

Variant ID Type Subtype PubMed ID
esv3627294 CNV gain 21293372
nsv832232 CNV gain 17160897

Variation tolerance for C11orf54 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf54 Gene

Disorders for C11orf54 Gene

Additional Disease Information for C11orf54

No disorders were found for C11orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf54 Gene

Publications for C11orf54 Gene

  1. Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold. (PMID: 16522806) Manjasetty BA … Heinemann U (Protein science : a publication of the Protein Society 2006) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C11orf54 Gene

Sources for C11orf54 Gene

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