Aliases for C11orf53 Gene

Aliases for C11orf53 Gene

  • Chromosome 11 Open Reading Frame 53 2 3 5
  • Uncharacterized Protein C11orf53 3 4
  • C11orf53 5
  • MGC50104 2

External Ids for C11orf53 Gene

Previous GeneCards Identifiers for C11orf53 Gene

  • GC11P110632
  • GC11P111126
  • GC11P107051

Summaries for C11orf53 Gene

GeneCards Summary for C11orf53 Gene

C11orf53 (Chromosome 11 Open Reading Frame 53) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf53 Gene

Genomics for C11orf53 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C11orf53 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111255 Promoter 0.4 EPDnew 250.4 +10.2 10195 0.1 POLR2A C11orf53 piR-57133-092 HSALNG0087089 COLCA2
GH11J111298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.1 +54.0 53994 2.5 SSRP1 POLR2A CTCF KMT2B THAP11 SMAD4 RXRA RARA GABPB1 TEAD3 COLCA2 RPS6P16 ALG9 ENSG00000235286 C11orf53 COLCA1 POU2AF1
GH11J111282 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.5 +37.9 37923 2.3 ZNF654 REST TRIM22 CTCF RAD21 SMC3 TEAD3 ZNF2 RB1 HDGF COLCA2 C11orf53 HSALNG0087089 HSALNG0087090
GH11J111302 Enhancer 1 Ensembl ENCODE dbSUPER 7.9 +57.3 57287 2 JUND YY1 ELF1 RXRA RARA ZNF205 HNF4A RAD21 CTCF ELF3 COLCA2 C11orf53 COLCA1 POU2AF1
GH11J111268 Enhancer 0.7 ENCODE 8.3 +24.0 23985 1.7 CEBPA FOXA2 SAP130 TEAD3 FOXP1 SOX5 HNF4A CBX2 LCORL RFX1 piR-57133-092 COLCA2 C11orf53 HSALNG0087089
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf53 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf53

Top Transcription factor binding sites by QIAGEN in the C11orf53 gene promoter:
  • AREB6
  • E47
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • Tal-1beta

Genomic Locations for C11orf53 Gene

Latest Assembly
chr11:111,245,725-111,286,401
(GRCh38/hg38)
Size:
40,677 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,116,450-111,157,126
(GRCh37/hg19 by Entrez Gene)
Size:
40,677 bases
Orientation:
Plus strand

chr11:111,126,707-111,157,126
(GRCh37/hg19 by Ensembl)
Size:
30,420 bases
Orientation:
Plus strand

Genomic View for C11orf53 Gene

Genes around C11orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf53 Gene

Proteins for C11orf53 Gene

  • Protein details for C11orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXP5-CK053_HUMAN
    Recommended name:
    Uncharacterized protein C11orf53
    Protein Accession:
    Q8IXP5

    Protein attributes for C11orf53 Gene

    Size:
    236 amino acids
    Molecular mass:
    25393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf53 Gene

Post-translational modifications for C11orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf53 Gene

No data available for DME Specific Peptides for C11orf53 Gene

Domains & Families for C11orf53 Gene

Gene Families for C11orf53 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf53 Gene

InterPro:
genes like me logo Genes that share domains with C11orf53: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf53 Gene

Function for C11orf53 Gene

Phenotypes From GWAS Catalog for C11orf53 Gene

genes like me logo Genes that share phenotypes with C11orf53: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf53 Gene

Localization for C11orf53 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf53 gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf53 Gene

Pathways & Interactions for C11orf53 Gene

PathCards logo

SuperPathways for C11orf53 Gene

No Data Available

Interacting Proteins for C11orf53 Gene

Selected Interacting proteins: Q8IXP5-CK053_HUMAN for C11orf53 Gene via MINT IID

Gene Ontology (GO) - Biological Process for C11orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf53 Gene

Drugs & Compounds for C11orf53 Gene

No Compound Related Data Available

Transcripts for C11orf53 Gene

mRNA/cDNA for C11orf53 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf53

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf53 Gene

No ASD Table

Relevant External Links for C11orf53 Gene

GeneLoc Exon Structure for
C11orf53

Expression for C11orf53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf53 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf53 Gene

This gene is overexpressed in Testis (x12.4), Breast - Mammary Tissue (x7.6), Stomach (x6.0), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for C11orf53 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf53 Gene



Protein tissue co-expression partners for C11orf53 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf53

SOURCE GeneReport for Unigene cluster for C11orf53 Gene:

Hs.298685
genes like me logo Genes that share expression patterns with C11orf53: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf53 Gene

Orthologs for C11orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf53 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11orf53 30
  • 100 (a)
OneToOne
C11H11orf53 29
  • 99.01 (n)
Rat
(Rattus norvegicus)
Mammalia RGD1562914 29
  • 81.7 (n)
Mouse
(Mus musculus)
Mammalia 1810046K07Rik 29 16 30
  • 80.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C5H11orf53 29
  • 79.57 (n)
C11orf53 30
  • 76 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C15H11orf53 29
  • 79.29 (n)
C11orf53 30
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C11orf53 30
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C11orf53 30
  • 54 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C11orf53 30
  • 39 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100496834 29
  • 57.18 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC101884656 29
  • 51.02 (n)
C15H11orf53 (2 of 2) 30
  • 32 (a)
OneToMany
C5H11orf53 (1 of 2) 30
  • 30 (a)
OneToMany
Species where no ortholog for C11orf53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C11orf53 Gene

ENSEMBL:
Gene Tree for C11orf53 (if available)
TreeFam:
Gene Tree for C11orf53 (if available)
Alliance of Genome Resources:
Additional Orthologs for C11orf53

Paralogs for C11orf53 Gene

No data available for Paralogs for C11orf53 Gene

Variants for C11orf53 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C11orf53 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C11orf53 Gene

Variant ID Type Subtype PubMed ID
esv3627729 CNV gain 21293372
esv3892101 CNV loss 25118596

Variation tolerance for C11orf53 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf53 Gene

Human Gene Mutation Database (HGMD)
C11orf53
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf53
Leiden Open Variation Database (LOVD)
C11orf53

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf53 Gene

Disorders for C11orf53 Gene

Additional Disease Information for C11orf53

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C11orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf53 Gene

Publications for C11orf53 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado AP … Narayanan R (Cancer genomics & proteomics 2014) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis. (PMID: 32918875) Funato Y … Miki H (Developmental cell 2020) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3

Products for C11orf53 Gene

Sources for C11orf53 Gene