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Aliases for C11orf53 Gene

Aliases for C11orf53 Gene

  • Chromosome 11 Open Reading Frame 53 2 3 5
  • Uncharacterized Protein C11orf53 3

External Ids for C11orf53 Gene

Previous GeneCards Identifiers for C11orf53 Gene

  • GC11P110632
  • GC11P111126
  • GC11P107051

Summaries for C11orf53 Gene

GeneCards Summary for C11orf53 Gene

C11orf53 (Chromosome 11 Open Reading Frame 53) is a Protein Coding gene.

Additional gene information for C11orf53 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf53 Gene

Genomics for C11orf53 Gene

GeneHancer (GH) Regulatory Elements for C11orf53 Gene

Promoters and enhancers for C11orf53 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111255 Promoter 0.6 EPDnew 650.4 +10.2 10216 0.1 POLR2A C11orf53 COLCA2
GH11J111298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 8.1 +54.0 54015 2.5 ELF3 ZFP64 SIN3A ZNF48 RAD21 RARA ZNF335 ZNF614 ZNF143 THAP11 COLCA2 C11orf53 COLCA1
GH11J111283 Enhancer 0.9 ENCODE dbSUPER 8.4 +38.4 38350 1 HDGF CTCF RB1 ZNF2 RAD21 PRPF4 ZNF143 ZSCAN29 MIXL1 GATAD2A C11orf53 COLCA2
GH11J111302 Enhancer 0.9 ENCODE dbSUPER 7.9 +57.4 57445 1.7 CTCF ELF3 MAX RAD21 RARA YY1 GATA3 ZNF350 PRDM10 NFKBIZ COLCA1 COLCA2 C11orf53
GH11J111268 Enhancer 0.7 ENCODE 8.3 +24.0 24006 1.7 SOX13 FOXA2 SAP130 ZNF384 TEAD3 LCORL HNF4G GATAD2A SOX5 RFX1 COLCA2 C11orf53
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C11orf53 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf53 gene promoter:
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • E47
  • Tal-1beta
  • AREB6
  • Oct-B1
  • oct-B2
  • oct-B3

Genomic Locations for C11orf53 Gene

Genomic Locations for C11orf53 Gene
chr11:111,245,704-111,286,406
(GRCh38/hg38)
Size:
40,703 bases
Orientation:
Plus strand
chr11:111,126,707-111,157,126
(GRCh37/hg19)
Size:
30,420 bases
Orientation:
Plus strand

Genomic View for C11orf53 Gene

Genes around C11orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf53 Gene

Proteins for C11orf53 Gene

  • Protein details for C11orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXP5-CK053_HUMAN
    Recommended name:
    Uncharacterized protein C11orf53
    Protein Accession:
    Q8IXP5

    Protein attributes for C11orf53 Gene

    Size:
    236 amino acids
    Molecular mass:
    25393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf53 Gene

Post-translational modifications for C11orf53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf53 Gene

No data available for DME Specific Peptides for C11orf53 Gene

Domains & Families for C11orf53 Gene

Gene Families for C11orf53 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf53 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf53: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf53 Gene

Function for C11orf53 Gene

Phenotypes From GWAS Catalog for C11orf53 Gene

genes like me logo Genes that share phenotypes with C11orf53: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf53 Gene

Localization for C11orf53 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf53 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf53 Gene

Pathways & Interactions for C11orf53 Gene

SuperPathways for C11orf53 Gene

No Data Available

Interacting Proteins for C11orf53 Gene

Selected Interacting proteins: Q8IXP5-CK053_HUMAN for C11orf53 Gene via IID MINT

Gene Ontology (GO) - Biological Process for C11orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf53 Gene

Drugs & Compounds for C11orf53 Gene

No Compound Related Data Available

Transcripts for C11orf53 Gene

mRNA/cDNA for C11orf53 Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf53 Gene

Chromosome 11 open reading frame 53:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf53 Gene

No ASD Table

Relevant External Links for C11orf53 Gene

GeneLoc Exon Structure for
C11orf53
ECgene alternative splicing isoforms for
C11orf53

Expression for C11orf53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf53 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf53 Gene

This gene is overexpressed in Testis (x12.4), Breast - Mammary Tissue (x7.6), Stomach (x6.0), and Colon - Transverse (x4.2).

Protein differential expression in normal tissues from HIPED for C11orf53 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf53 Gene



Protein tissue co-expression partners for C11orf53 Gene

NURSA nuclear receptor signaling pathways regulating expression of C11orf53 Gene:

C11orf53

SOURCE GeneReport for Unigene cluster for C11orf53 Gene:

Hs.298685
genes like me logo Genes that share expression patterns with C11orf53: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf53 Gene

Orthologs for C11orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11orf53 34
  • 100 (a)
OneToOne
C11H11orf53 33
  • 99.01 (n)
rat
(Rattus norvegicus)
Mammalia RGD1562914 33
  • 81.7 (n)
mouse
(Mus musculus)
Mammalia 1810046K07Rik 16 34 33
  • 80.71 (n)
dog
(Canis familiaris)
Mammalia C5H11orf53 33
  • 79.57 (n)
C11orf53 34
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf53 33
  • 79.29 (n)
C11orf53 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf53 34
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C11orf53 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf53 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496834 33
  • 57.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101884656 33
  • 51.02 (n)
C15H11orf53 (2 of 2) 34
  • 32 (a)
OneToMany
C5H11orf53 (1 of 2) 34
  • 30 (a)
OneToMany
Species where no ortholog for C11orf53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf53 Gene

ENSEMBL:
Gene Tree for C11orf53 (if available)
TreeFam:
Gene Tree for C11orf53 (if available)

Paralogs for C11orf53 Gene

No data available for Paralogs for C11orf53 Gene

Variants for C11orf53 Gene

Sequence variations from dbSNP and Humsavar for C11orf53 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010171 -- 111,251,729(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000203210 -- 111,276,319(+) C/T intron_variant
rs1000268392 -- 111,252,203(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000338326 -- 111,282,922(+) C/A intron_variant
rs1000344623 -- 111,282,354(+) TTTTTT/TTTTTTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf53 Gene

Variant ID Type Subtype PubMed ID
esv3892101 CNV loss 25118596
esv3627729 CNV gain 21293372

Variation tolerance for C11orf53 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf53 Gene

Human Gene Mutation Database (HGMD)
C11orf53
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf53 Gene

Disorders for C11orf53 Gene

Additional Disease Information for C11orf53

No disorders were found for C11orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf53 Gene

Publications for C11orf53 Gene

  1. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado AP … Narayanan R (Cancer genomics & proteomics 2014) 2 3 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for C11orf53 Gene

Sources for C11orf53 Gene

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