Aliases for C11orf52 Gene

Aliases for C11orf52 Gene

  • Chromosome 11 Open Reading Frame 52 2 3 5
  • Uncharacterized Protein C11orf52 3 4
  • C11orf52 5
  • MGC14839 2
  • FLJ25219 2

External Ids for C11orf52 Gene

Previous GeneCards Identifiers for C11orf52 Gene

  • GC11P111295
  • GC11P111789
  • GC11P107713

Summaries for C11orf52 Gene

GeneCards Summary for C11orf52 Gene

C11orf52 (Chromosome 11 Open Reading Frame 52) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf52 Gene

Genomics for C11orf52 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C11orf52 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf52 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf52

Top Transcription factor binding sites by QIAGEN in the C11orf52 gene promoter:
  • c-Myc
  • Max1
  • NF-kappaB
  • NF-kappaB1
  • Sp1

Genomic Locations for C11orf52 Gene

Latest Assembly
chr11:111,918,032-111,926,871
(GRCh38/hg38)
Size:
8,840 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,789,637-111,797,595
(GRCh37/hg19 by Entrez Gene)
Size:
7,959 bases
Orientation:
Plus strand

chr11:111,788,756-111,797,596
(GRCh37/hg19 by Ensembl)
Size:
8,841 bases
Orientation:
Plus strand

Genomic View for C11orf52 Gene

Genes around C11orf52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf52 Gene

Proteins for C11orf52 Gene

  • Protein details for C11orf52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A22-CK052_HUMAN
    Recommended name:
    Uncharacterized protein C11orf52
    Protein Accession:
    Q96A22

    Protein attributes for C11orf52 Gene

    Size:
    123 amino acids
    Molecular mass:
    13921 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf52 Gene

Post-translational modifications for C11orf52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C11orf52 Gene

Domains & Families for C11orf52 Gene

Gene Families for C11orf52 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf52 Gene

InterPro:
genes like me logo Genes that share domains with C11orf52: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf52 Gene

Function for C11orf52 Gene

Phenotypes From GWAS Catalog for C11orf52 Gene

Gene Ontology (GO) - Molecular Function for C11orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with C11orf52: view
genes like me logo Genes that share phenotypes with C11orf52: view

miRNA for C11orf52 Gene

miRTarBase miRNAs that target C11orf52

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf52

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf52 Gene

Localization for C11orf52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf52 gene
Compartment Confidence
extracellular 4
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with C11orf52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf52 Gene

Pathways & Interactions for C11orf52 Gene

PathCards logo

SuperPathways for C11orf52 Gene

No Data Available

Interacting Proteins for C11orf52 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q96A22-CK052_HUMAN ENSP00000278601 for C11orf52 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for C11orf52 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf52 Gene

Drugs & Compounds for C11orf52 Gene

No Compound Related Data Available

Transcripts for C11orf52 Gene

mRNA/cDNA for C11orf52 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf52

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf52 Gene

No ASD Table

Relevant External Links for C11orf52 Gene

GeneLoc Exon Structure for
C11orf52

Expression for C11orf52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf52 Gene

Protein differential expression in normal tissues from HIPED for C11orf52 Gene

This gene is overexpressed in Urine (39.2), Placenta (13.7), and Lung (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf52 Gene



Protein tissue co-expression partners for C11orf52 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf52

SOURCE GeneReport for Unigene cluster for C11orf52 Gene:

Hs.97013

Evidence on tissue expression from TISSUES for C11orf52 Gene

  • Liver(4.2)
  • Stomach(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C11orf52: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf52 Gene

Orthologs for C11orf52 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf52 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11H11orf52 29
  • 99.19 (n)
C11orf52 30
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C5H11orf52 29
  • 82.38 (n)
C11orf52 30
  • 66 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C15H11orf52 29
  • 81.84 (n)
C11orf52 30
  • 62 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 2310030G06Rik 29 16 30
  • 75.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC689959 29
  • 72.9 (n)
Species where no ortholog for C11orf52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C11orf52 Gene

ENSEMBL:
Gene Tree for C11orf52 (if available)
TreeFam:
Gene Tree for C11orf52 (if available)
Alliance of Genome Resources:
Additional Orthologs for C11orf52

Paralogs for C11orf52 Gene

No data available for Paralogs for C11orf52 Gene

Variants for C11orf52 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf52 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs7124407 -- p.Thr23Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C11orf52 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for C11orf52 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf52
Leiden Open Variation Database (LOVD)
C11orf52

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C11orf52 Gene

Disorders for C11orf52 Gene

Additional Disease Information for C11orf52

No disorders were found for C11orf52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf52 Gene

Publications for C11orf52 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3

Products for C11orf52 Gene

Sources for C11orf52 Gene