Aliases for C11orf42 Gene

Aliases for C11orf42 Gene

  • Chromosome 11 Open Reading Frame 42 2 3 5
  • Uncharacterized Protein C11orf42 3 4
  • C11orf42 5
  • MGC34805 2

External Ids for C11orf42 Gene

Previous GeneCards Identifiers for C11orf42 Gene

  • GC11P006187
  • GC11P005888

Summaries for C11orf42 Gene

GeneCards Summary for C11orf42 Gene

C11orf42 (Chromosome 11 Open Reading Frame 42) is a Protein Coding gene.

Additional gene information for C11orf42 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf42 Gene

Genomics for C11orf42 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C11orf42 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006196 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 +0.1 95 11.6 IKZF2 PKNOX1 CEBPA CEBPB RELB RUNX3 YY1 ELF1 NBN HDGF C11orf42 FAM160A2 CCKBR CNGA4 TRIM5 TPP1 ENSG00000267940 OR52W1
GH11J007019 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 +818.4 818404 2.5 TEAD4 RFX1 KDM1A PKNOX1 POLR2A ZNF24 REST SP1 ZNF501 GABPA ZNF214 NLRP14 lnc-OR2D2-2 piR-48528 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 ZNF215
GH11J006249 Enhancer 1 Ensembl ENCODE 10.9 +48.1 48128 1.3 PRDM10 JUND PRDM1 DPF2 SOX6 TCF12 EP300 ZNF766 CEBPB BRCA1 C11orf42 OR52W1 CAVIN3 OR56A1 CCKBR CNGA4
GH11J006239 Promoter/Enhancer 0.7 EPDnew FANTOM5 Ensembl 10.9 +38.3 38296 2.8 CNGA4 CCKBR C11orf42 OR52W1 CAVIN3 OR52B2 TPP1 FAM160A2
GH11J006250 Enhancer 0.7 ENCODE 10.5 +50.4 50435 2.8 CTCF IKZF1 REST RAD21 EGR1 FOXA2 SMC3 TRIM24 NCOR1 POLR2A FAM160A2 CCKBR OR52W1 C11orf42 OR56A1 CNGA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf42 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf42

Top Transcription factor binding sites by QIAGEN in the C11orf42 gene promoter:
  • Gfi-1
  • HEN1
  • Lmo2
  • MyoD
  • NF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RREB-1
  • Spz1

Genomic Locations for C11orf42 Gene

Genomic Locations for C11orf42 Gene
chr11:6,201,905-6,226,783
(GRCh38/hg38)
Size:
24,879 bases
Orientation:
Plus strand
chr11:6,226,796-6,232,365
(GRCh37/hg19)
Size:
5,570 bases
Orientation:
Plus strand

Genomic View for C11orf42 Gene

Genes around C11orf42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf42 Gene

Proteins for C11orf42 Gene

  • Protein details for C11orf42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U0-CK042_HUMAN
    Recommended name:
    Uncharacterized protein C11orf42
    Protein Accession:
    Q8N5U0

    Protein attributes for C11orf42 Gene

    Size:
    333 amino acids
    Molecular mass:
    36368 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf42 Gene

Post-translational modifications for C11orf42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf42 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C11orf42 Gene

Domains & Families for C11orf42 Gene

Gene Families for C11orf42 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf42 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C11orf42: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf42 Gene

Function for C11orf42 Gene

Phenotypes From GWAS Catalog for C11orf42 Gene

genes like me logo Genes that share phenotypes with C11orf42: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf42

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf42 Gene

Localization for C11orf42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf42 gene
Compartment Confidence
peroxisome 1
cytosol 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf42 Gene

Pathways & Interactions for C11orf42 Gene

PathCards logo

SuperPathways for C11orf42 Gene

No Data Available

Interacting Proteins for C11orf42 Gene

Gene Ontology (GO) - Biological Process for C11orf42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf42 Gene

Drugs & Compounds for C11orf42 Gene

No Compound Related Data Available

Transcripts for C11orf42 Gene

mRNA/cDNA for C11orf42 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf42

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf42 Gene

No ASD Table

Relevant External Links for C11orf42 Gene

GeneLoc Exon Structure for
C11orf42

Expression for C11orf42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf42 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf42 Gene

This gene is overexpressed in Testis (x36.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf42 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf42

SOURCE GeneReport for Unigene cluster for C11orf42 Gene:

Hs.278221
genes like me logo Genes that share expression patterns with C11orf42: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf42 Gene

Orthologs for C11orf42 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf42 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11H11orf42 30
  • 99.6 (n)
C11orf42 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C11orf42 31
  • 90 (a)
OneToOne
C21H11orf42 30
  • 89.99 (n)
Cow
(Bos Taurus)
Mammalia C15H11orf42 30
  • 89.09 (n)
C11orf42 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1561034 30
  • 88.19 (n)
Mouse
(Mus musculus)
Mammalia Gm5901 30 17 31
  • 87.99 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C11orf42 31
  • 66 (a)
OneToOne
Species where no ortholog for C11orf42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C11orf42 Gene

ENSEMBL:
Gene Tree for C11orf42 (if available)
TreeFam:
Gene Tree for C11orf42 (if available)

Paralogs for C11orf42 Gene

No data available for Paralogs for C11orf42 Gene

Variants for C11orf42 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf42 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs117940741 Uncertain Significance: Malignant tumor of prostate 6,214,426(+) G/A MISSENSE_VARIANT
rs10769671 - p.Pro242Ser

Additional dbSNP identifiers (rs#s) for C11orf42 Gene

Variation tolerance for C11orf42 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C11orf42 Gene

Disorders for C11orf42 Gene

No disorders were found for C11orf42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf42 Gene

Publications for C11orf42 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for C11orf42 Gene

Sources for C11orf42 Gene