Aliases for C11orf24 Gene

Aliases for C11orf24 Gene

  • Chromosome 11 Open Reading Frame 24 2 3 5
  • Uncharacterized Protein C11orf24 3 4
  • DM4E3 2 3
  • Protein DM4E3 4
  • C11orf24 5

External Ids for C11orf24 Gene

Previous GeneCards Identifiers for C11orf24 Gene

  • GC11M070551
  • GC11M069725
  • GC11M068278
  • GC11M067804
  • GC11M067787
  • GC11M068028
  • GC11M064363
  • GC11M068262

Summaries for C11orf24 Gene

GeneCards Summary for C11orf24 Gene

C11orf24 (Chromosome 11 Open Reading Frame 24) is a Protein Coding gene. Diseases associated with C11orf24 include Type 1 Diabetes Mellitus 4. An important paralog of this gene is MANSC1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf24 Gene

Genomics for C11orf24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C11orf24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf24

Top Transcription factor binding sites by QIAGEN in the C11orf24 gene promoter:
  • ATF
  • c-Myc
  • FOXI1
  • HFH-3
  • Ik-1
  • Max1
  • NRF-2
  • POU2F1
  • POU2F1a
  • PPAR-alpha

Genomic Locations for C11orf24 Gene

Latest Assembly
10,664 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
10,636 bases
Minus strand

(GRCh37/hg19 by Ensembl)
10,667 bases
Minus strand

Genomic View for C11orf24 Gene

Genes around C11orf24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf24 Gene

Proteins for C11orf24 Gene

  • Protein details for C11orf24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf24
    Protein Accession:
    Secondary Accessions:
    • Q9H2K4

    Protein attributes for C11orf24 Gene

    449 amino acids
    Molecular mass:
    46101 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf24 Gene

Post-translational modifications for C11orf24 Gene

  • Glycosylation at Asn49, Thr204, Thr206, Thr209, and Thr212
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf24 Gene

No data available for DME Specific Peptides for C11orf24 Gene

Domains & Families for C11orf24 Gene

Gene Families for C11orf24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C11orf24 Gene


Suggested Antigen Peptide Sequences for C11orf24 Gene

GenScript: Design optimal peptide antigens:
  • Protein DM4E3 (CK024_HUMAN)
genes like me logo Genes that share domains with C11orf24: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf24 Gene

Function for C11orf24 Gene

Phenotypes From GWAS Catalog for C11orf24 Gene

Gene Ontology (GO) - Molecular Function for C11orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with C11orf24: view
genes like me logo Genes that share phenotypes with C11orf24: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf24 Gene

Localization for C11orf24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf24 Gene

Cell membrane. Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane. Single-pass type I membrane protein. Note=Cycles to the plasma membrane via endosomes in a pH sensitive manner. Associated with Rab6-positive vesicles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf24 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
endosome 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C11orf24: view

Pathways & Interactions for C11orf24 Gene

PathCards logo

SuperPathways for C11orf24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf24 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf24 Gene

Drugs & Compounds for C11orf24 Gene

No Compound Related Data Available

Transcripts for C11orf24 Gene

mRNA/cDNA for C11orf24 Gene

8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf24

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf24 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -

Relevant External Links for C11orf24 Gene

GeneLoc Exon Structure for

Expression for C11orf24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf24 Gene

Protein differential expression in normal tissues from HIPED for C11orf24 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf24 Gene

Protein tissue co-expression partners for C11orf24 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf24

SOURCE GeneReport for Unigene cluster for C11orf24 Gene:


mRNA Expression by UniProt/SwissProt for C11orf24 Gene:

Tissue specificity: Highest expression in heart, placenta, liver, pancreas and colon. Also detected in brain, lung, skeletal muscle, kidney, spleen, prostate, testis, ovary and small intestine. Lowest expression in thymus and leukocytes.

Evidence on tissue expression from TISSUES for C11orf24 Gene

  • Skin(4.4)
genes like me logo Genes that share expression patterns with C11orf24: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf24 Gene

Orthologs for C11orf24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11orf24 30
  • 99 (a)
C11H11orf24 29
  • 98.95 (n)
(Rattus norvegicus)
Mammalia RGD1311946 29
  • 73.13 (n)
(Mus musculus)
Mammalia 1810055G02Rik 29 16 30
  • 67.18 (n)
(Bos Taurus)
Mammalia MGC139603 29
  • 67.03 (n)
C11orf24 30
  • 50 (a)
(Canis familiaris)
Mammalia C18H11orf24 29
  • 63.59 (n)
C11orf24 30
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf24 30
  • 29 (a)
(Monodelphis domestica)
Mammalia C11orf24 30
  • 25 (a)
(Gallus gallus)
Aves C11orf24 30
  • 23 (a)
(Anolis carolinensis)
Reptilia C11orf24 30
  • 44 (a)
(Danio rerio)
Actinopterygii C25H11orf24 30
  • 23 (a)
Species where no ortholog for C11orf24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C11orf24 Gene

Gene Tree for C11orf24 (if available)
Gene Tree for C11orf24 (if available)
Alliance of Genome Resources:
Additional Orthologs for C11orf24

Paralogs for C11orf24 Gene

Paralogs for C11orf24 Gene

genes like me logo Genes that share paralogs with C11orf24: view

Variants for C11orf24 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf24 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs3802746 -- p.Gly97Val
rs901827 -- p.Ala150Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C11orf24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C11orf24 Gene

Variant ID Type Subtype PubMed ID
esv1166069 CNV insertion 17803354
esv1589088 CNV insertion 17803354
esv2584634 CNV insertion 19546169
nsv825963 CNV gain 20364138

Variation tolerance for C11orf24 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.78; 91.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf24 Gene

Disorders for C11orf24 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C11orf24 Gene - From: COP

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 4
  • t1d4
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C11orf24

genes like me logo Genes that share disorders with C11orf24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf24 Gene

Publications for C11orf24 Gene

  1. C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles. (PMID: 24312644) Fraisier V … Dimitrov A (PloS one 2013) 2 3 4
  2. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. (PMID: 11401438) Twells RC … Hess JF (Genomics 2001) 2 3 4
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for C11orf24 Gene

Sources for C11orf24 Gene