Aliases for C11orf21 Gene

Aliases for C11orf21 Gene

  • Chromosome 11 Open Reading Frame 21 2 3 5
  • Uncharacterized Protein C11orf21 3 4

External Ids for C11orf21 Gene

Previous GeneCards Identifiers for C11orf21 Gene

  • GC11M002378
  • GC11M002517
  • GC11M002277
  • GC11M002281
  • GC11U900669
  • GC11M002121
  • GC11M002316

Summaries for C11orf21 Gene

GeneCards Summary for C11orf21 Gene

C11orf21 (Chromosome 11 Open Reading Frame 21) is a Protein Coding gene. Diseases associated with C11orf21 include Beckwith-Wiedemann Syndrome.

Additional gene information for C11orf21 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf21 Gene

Genomics for C11orf21 Gene

GeneHancer (GH) Regulatory Elements for C11orf21 Gene

Promoters and enhancers for C11orf21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002298 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 524.3 -0.5 -532 9.4 CTCF PHB2 ZIC2 ZNF263 ZBTB11 GABPA REST HES1 TOE1 MYC C11orf21 TSPAN32 lnc-C11orf21-2 RNU6-878P
GH11J002294 Enhancer 0.7 Ensembl ENCODE 24.3 +8.6 8648 3.2 CTCF ZNF10 REST CTBP1 SMC3 RAD21 SPI1 MITF POLR2A CEBPB C11orf21 ASCL2 RNU6-878P TRPM5 ENSG00000199550 CD81 TSPAN32 piR-38791
GH11J002209 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 12.1 +93.0 92962 3.8 EP300 TCF12 POLR2G NCOR1 ZIC2 KDM6A TCF7 FOXA1 ZBTB25 TGIF2 TSPAN32 C11orf21 TH ENSG00000236710 lnc-TH-1 lnc-TSPAN32-4
GH11J002443 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.7 -143.2 -143237 4.6 CTCF ZIC2 ZNF423 ZBTB26 EZH2 KLF9 SP2 POLR2A PHF8 SPI1 KCNQ1 HSALNG0082233 NONHSAG007430.2 C11orf21 TSPAN32 TRPM5 TSSC4 INS piR-48369-028
GH11J002286 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.3 +16.2 16234 2 REST TOE1 FOSL1 MNT NR2F1 TAL1 FOXK2 MITF DPF2 MEIS2 TSPAN32 C11orf21 KCNQ1 piR-38791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf21

Top Transcription factor binding sites by QIAGEN in the C11orf21 gene promoter:
  • C/EBPalpha
  • CHOP-10
  • CREB
  • deltaCREB
  • Elk-1
  • MyoD
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • RP58

Genomic Locations for C11orf21 Gene

Genomic Locations for C11orf21 Gene
chr11:2,295,645-2,303,049
(GRCh38/hg38)
Size:
7,405 bases
Orientation:
Minus strand
chr11:2,316,875-2,324,279
(GRCh37/hg19)
Size:
7,405 bases
Orientation:
Minus strand

Genomic View for C11orf21 Gene

Genes around C11orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf21 Gene

Proteins for C11orf21 Gene

  • Protein details for C11orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2W6-CK021_HUMAN
    Recommended name:
    Uncharacterized protein C11orf21
    Protein Accession:
    Q9P2W6

    Protein attributes for C11orf21 Gene

    Size:
    132 amino acids
    Molecular mass:
    14447 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf21 Gene

Post-translational modifications for C11orf21 Gene

No Post-translational modifications

Other Protein References for C11orf21 Gene

No data available for DME Specific Peptides for C11orf21 Gene

Domains & Families for C11orf21 Gene

Gene Families for C11orf21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf21 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C11orf21: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C11orf21 Gene

Function for C11orf21 Gene

Phenotypes From GWAS Catalog for C11orf21 Gene

genes like me logo Genes that share phenotypes with C11orf21: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf21 Gene

Localization for C11orf21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf21 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf21 gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with C11orf21: view

Pathways & Interactions for C11orf21 Gene

PathCards logo

SuperPathways for C11orf21 Gene

No Data Available

Interacting Proteins for C11orf21 Gene

;

Gene Ontology (GO) - Biological Process for C11orf21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf21 Gene

Drugs & Compounds for C11orf21 Gene

No Compound Related Data Available

Transcripts for C11orf21 Gene

mRNA/cDNA for C11orf21 Gene

3 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: -

Relevant External Links for C11orf21 Gene

GeneLoc Exon Structure for
C11orf21

Expression for C11orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C11orf21 Gene

This gene is overexpressed in Whole Blood (x22.3), Heart - Left Ventricle (x9.2), and Spleen (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf21

SOURCE GeneReport for Unigene cluster for C11orf21 Gene:

Hs.559181

mRNA Expression by UniProt/SwissProt for C11orf21 Gene:

Q9P2W6-CK021_HUMAN
Tissue specificity: Expressed exclusively in heart.
genes like me logo Genes that share expression patterns with C11orf21: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf21 Gene

Orthologs for C11orf21 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C11orf21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11orf21 31
  • 96 (a)
OneToOne
C11H11orf21 30
  • 90.89 (n)
Species where no ortholog for C11orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf21 Gene

ENSEMBL:
Gene Tree for C11orf21 (if available)
TreeFam:
Gene Tree for C11orf21 (if available)

Paralogs for C11orf21 Gene

No data available for Paralogs for C11orf21 Gene

Variants for C11orf21 Gene

Additional dbSNP identifiers (rs#s) for C11orf21 Gene

Structural Variations from Database of Genomic Variants (DGV) for C11orf21 Gene

Variant ID Type Subtype PubMed ID
esv2744000 CNV deletion 23290073
esv2744001 CNV deletion 23290073
esv2744002 CNV deletion 23290073
esv29043 CNV gain 19812545
nsv1070427 CNV deletion 25765185
nsv467645 CNV gain 19166990
nsv467651 CNV loss 19166990
nsv469928 CNV loss 18288195
nsv553047 CNV gain 21841781
nsv553080 CNV loss 21841781
nsv553081 CNV loss 21841781
nsv553082 CNV loss 21841781
nsv553083 CNV gain+loss 21841781
nsv553084 CNV gain+loss 21841781
nsv553085 CNV gain 21841781
nsv553086 CNV loss 21841781
nsv951285 CNV deletion 24416366

Variation tolerance for C11orf21 Gene

Gene Damage Index Score: 4.53; 64.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf21 Gene

Disorders for C11orf21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C11orf21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • bws
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C11orf21

genes like me logo Genes that share disorders with C11orf21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf21 Gene

Publications for C11orf21 Gene

  1. C11orf21, a novel gene within the Beckwith-Wiedemann syndrome region in human chromosome 11p15.5. (PMID: 11054561) Zhu X … Joh K (Gene 2000) 2 3 4 54
  2. A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia. (PMID: 24292274) Speedy HE … Houlston RS (Nature genetics 2014) 3 54
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 54
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54

Products for C11orf21 Gene

Sources for C11orf21 Gene