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Aliases for C11orf16 Gene

Aliases for C11orf16 Gene

  • Chromosome 11 Open Reading Frame 16 2 3 5
  • Uncharacterized Protein C11orf16 3 4

External Ids for C11orf16 Gene

Previous GeneCards Identifiers for C11orf16 Gene

  • GC11P009967
  • GC11M009632
  • GC11M008980
  • GC11M008905
  • GC11M008898
  • GC11M008611

Summaries for C11orf16 Gene

GeneCards Summary for C11orf16 Gene

C11orf16 (Chromosome 11 Open Reading Frame 16) is a Protein Coding gene.

Gene Wiki entry for C11orf16 Gene

Additional gene information for C11orf16 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf16 Gene

Genomics for C11orf16 Gene

GeneHancer (GH) Regulatory Elements for C11orf16 Gene

Promoters and enhancers for C11orf16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J008932 Promoter/Enhancer 0.8 EPDnew ENCODE 550.7 0.0 -14 0.2 RFX1 C11orf16 AKIP1 ASCL3
GH11J008905 Enhancer 0.8 ENCODE 6.5 +26.3 26333 3.2 ZBTB33 MAFK POLR2A SP7 PKNOX1 LEF1 ZEB2 ATF7 ZNF629 ZNF692 TMEM9B-AS1 AKIP1 ENSG00000223080 ASCL3 TMEM9B SCUBE2 C11orf16 ST5 GC11M008877 ENSG00000202276
GH11J008865 Enhancer 1.1 FANTOM5 Ensembl ENCODE 4.4 +65.6 65603 4 ZNF362 ZNF384 SP7 SCRT2 CEBPB RCOR1 EP300 RAD21 TCF7L2 ZFHX2 TMEM9B-AS1 AKIP1 SCUBE2 C11orf16 ST5 ENSG00000202276 GC11M008877 RNA5SP330
GH11J008934 Enhancer 0.9 Ensembl ENCODE 0.7 -2.2 -2161 1.5 SMARCA4 IKZF1 PKNOX1 JUN HDAC2 JUND FOS FOSL1 EP300 RFX5 AKIP1 ST5 TMEM9B-AS1 C11orf16 ASCL3
GH11J008909 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.3 +21.7 21704 3.1 SP1 ZFX MLLT1 L3MBTL2 SMARCA4 ZNF362 ELF1 YY1 KLF14 ZNF384 AKIP1 ST5 SCUBE2 TMEM9B-AS1 C11orf16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C11orf16 gene promoter:
  • AML1a
  • AP-1
  • AP-4
  • ATF-2
  • c-Jun
  • COMP1
  • ER-alpha
  • NRSF form 2
  • RORalpha1

Genomic Locations for C11orf16 Gene

Genomic Locations for C11orf16 Gene
12,931 bases
Minus strand
12,931 bases
Minus strand

Genomic View for C11orf16 Gene

Genes around C11orf16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf16 Gene

Proteins for C11orf16 Gene

  • Protein details for C11orf16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf16
    Protein Accession:
    Secondary Accessions:
    • Q53FB2
    • Q8N6Y9

    Protein attributes for C11orf16 Gene

    467 amino acids
    Molecular mass:
    51609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf16 Gene


neXtProt entry for C11orf16 Gene

Post-translational modifications for C11orf16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf16 Gene

No data available for DME Specific Peptides for C11orf16 Gene

Domains & Families for C11orf16 Gene

Gene Families for C11orf16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf16 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf16: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf16 Gene

Function for C11orf16 Gene

Phenotypes From GWAS Catalog for C11orf16 Gene

genes like me logo Genes that share phenotypes with C11orf16: view

Animal Model Products

CRISPR Products

miRNA for C11orf16 Gene

miRTarBase miRNAs that target C11orf16

Clone Products

  • Applied Biological Materials (abm): Clones for C11orf16 - Now 50% OFF >
  • * C11orf16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C11orf16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf16 Gene

Localization for C11orf16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf16 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C11orf16 Gene

Pathways & Interactions for C11orf16 Gene

SuperPathways for C11orf16 Gene

No Data Available

Interacting Proteins for C11orf16 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
Selected Interacting proteins: Q9NQ32-CK016_HUMAN ENSP00000318999 for C11orf16 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for C11orf16 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf16 Gene

Drugs & Compounds for C11orf16 Gene

No Compound Related Data Available

Transcripts for C11orf16 Gene

mRNA/cDNA for C11orf16 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for C11orf16 Gene

Chromosome 11 open reading frame 16:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for C11orf16 - Now 50% OFF >
  • * C11orf16 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C11orf16 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf16 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for C11orf16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C11orf16 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf16 Gene

This gene is overexpressed in Fallopian Tube (x11.0), Cervix - Endocervix (x8.5), Testis (x8.0), and Lung (x6.7).

Protein differential expression in normal tissues from HIPED for C11orf16 Gene

This gene is overexpressed in Pancreatic juice (54.3) and Adipocyte (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf16 Gene

Protein tissue co-expression partners for C11orf16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf16 Gene:


SOURCE GeneReport for Unigene cluster for C11orf16 Gene:

genes like me logo Genes that share expression patterns with C11orf16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf16 Gene

Orthologs for C11orf16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C11H11orf16 34
  • 98.5 (n)
C11orf16 35
  • 97 (a)
(Bos Taurus)
Mammalia C15H11orf16 34
  • 79.18 (n)
C11ORF16 35
  • 65 (a)
(Canis familiaris)
Mammalia C21H11orf16 34
  • 77.9 (n)
C11orf16 35
  • 60 (a)
(Rattus norvegicus)
Mammalia LOC499240 34
  • 74.49 (n)
(Mus musculus)
Mammalia BC051019 17 35 34
  • 73.37 (n)
(Monodelphis domestica)
Mammalia C11orf16 35
  • 45 (a)
(Gallus gallus)
Aves C11ORF16 34
  • 51.51 (n)
C11orf16 35
  • 34 (a)
(Anolis carolinensis)
Reptilia C11orf16 35
  • 56 (a)
Species where no ortholog for C11orf16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf16 Gene

Gene Tree for C11orf16 (if available)
Gene Tree for C11orf16 (if available)

Paralogs for C11orf16 Gene

No data available for Paralogs for C11orf16 Gene

Variants for C11orf16 Gene

Sequence variations from dbSNP and Humsavar for C11orf16 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000052672 -- 8,934,906(-) G/A/T upstream_transcript_variant
rs1000063773 -- 8,926,385(-) G/A intron_variant
rs1000079087 -- 8,920,464(-) A/G intron_variant
rs1000100418 -- 8,928,844(-) A/G intron_variant
rs1000168262 -- 8,929,283(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf16 Gene

Variant ID Type Subtype PubMed ID
esv2759803 CNV gain 17122850
nsv435923 CNV deletion 17901297
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855
nsv832062 CNV loss 17160897

Variation tolerance for C11orf16 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.11; 87.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf16 Gene

Disorders for C11orf16 Gene

Additional Disease Information for C11orf16

No disorders were found for C11orf16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf16 Gene

Publications for C11orf16 Gene

  1. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C … Schmidt ER (Cytogenetics and cell genetics 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. (PMID: 27503909) Teixeira FR … Laman H (The Biochemical journal 2016) 3 58
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for C11orf16 Gene

Sources for C11orf16 Gene

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