Aliases for C11orf58 Gene

Aliases for C11orf58 Gene

  • Chromosome 11 Open Reading Frame 58 2 3 5
  • Small Acidic Protein 2 3 4
  • IMAGE145052 3
  • SMAP 3

External Ids for C11orf58 Gene

Previous GeneCards Identifiers for C11orf58 Gene

  • GC11P016717
  • GC11P016444

Summaries for C11orf58 Gene

GeneCards Summary for C11orf58 Gene

C11orf58 (Chromosome 11 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C11orf58 include Ataxia, Sensory, 1, Autosomal Dominant and Gaucher's Disease.

Gene Wiki entry for C11orf58 Gene

Additional gene information for C11orf58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C11orf58 Gene

Genomics for C11orf58 Gene

GeneHancer (GH) Regulatory Elements for C11orf58 Gene

Promoters and enhancers for C11orf58 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J016737 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.1 +126.6 126596 4.5 EP300 ZNF217 SIN3A TCF12 POLR2G GTF2E2 PHF8 JUND SIX5 ZFX SOX6 lnc-SOX6-3 C11orf58 lnc-C11orf58-8
GH11J016611 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +0.4 365 3 ZNF217 CTCF NRF1 ZIC2 ZBTB26 REST RAD21 CTBP1 EZH2 ZEB1 C11orf58 LOC105376571 piR-54414 lnc-SOX6-3 SOX6
GH11J017075 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 +464.4 464368 3.8 FOXK2 ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 PHF8 RPS13 SNORD14B lnc-NUCB2-11 lnc-RPS13-1 ENSG00000244398 SNORD14A OR7E14P C11orf58 PIK3C2A lnc-PIK3C2A-1
GH11J015965 Promoter/Enhancer 2.1 UCNEbase FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.6 -644.8 -644819 6.4 POLR2G GTF2E2 JUND FOS EP300 POLR2A KLF4 RFX1 MYC CTBP1 MIR6073 lnc-PLEKHA7-8 ENSG00000254878 C11orf58 SOX6
GH11J016761 Enhancer 0.7 Ensembl 21.6 +148.7 148669 0.8 JUND FOS ZNF639 ZNF623 ZNF316 MAFF MAFK ZBTB11 ZNF426 NFE2 C11orf58 SOX6 piR-57133-069 lnc-PLEKHA7-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C11orf58 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C11orf58

Top Transcription factor binding sites by QIAGEN in the C11orf58 gene promoter:
  • aMEF-2
  • E2F
  • E2F-1
  • Ik-1
  • Lmo2
  • MEF-2A
  • Nkx2-5
  • Roaz
  • Sox5
  • SRY

Genomic Locations for C11orf58 Gene

Genomic Locations for C11orf58 Gene
chr11:16,613,132-16,758,354
(GRCh38/hg38)
Size:
145,223 bases
Orientation:
Plus strand
chr11:16,634,679-16,779,901
(GRCh37/hg19)
Size:
145,223 bases
Orientation:
Plus strand

Genomic View for C11orf58 Gene

Genes around C11orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf58 Gene

Proteins for C11orf58 Gene

  • Protein details for C11orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00193-SMAP_HUMAN
    Recommended name:
    Small acidic protein
    Protein Accession:
    O00193
    Secondary Accessions:
    • B2RD28

    Protein attributes for C11orf58 Gene

    Size:
    183 amino acids
    Molecular mass:
    20333 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C11orf58 Gene

Post-translational modifications for C11orf58 Gene

  • Ubiquitination at Lys62, Lys75, Lys91, Lys174, and Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf58 Gene

No data available for DME Specific Peptides for C11orf58 Gene

Domains & Families for C11orf58 Gene

Gene Families for C11orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C11orf58 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00193

UniProtKB/Swiss-Prot:

SMAP_HUMAN :
  • Belongs to the SMAP family.
Family:
  • Belongs to the SMAP family.
genes like me logo Genes that share domains with C11orf58: view

No data available for Suggested Antigen Peptide Sequences for C11orf58 Gene

Function for C11orf58 Gene

Phenotypes From GWAS Catalog for C11orf58 Gene

Gene Ontology (GO) - Molecular Function for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C11orf58: view
genes like me logo Genes that share phenotypes with C11orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf58

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf58 Gene

Localization for C11orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf58 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C11orf58 Gene

Pathways & Interactions for C11orf58 Gene

PathCards logo

SuperPathways for C11orf58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C11orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C11orf58: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf58 Gene

Drugs & Compounds for C11orf58 Gene

(1) Drugs for C11orf58 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with C11orf58: view

Transcripts for C11orf58 Gene

mRNA/cDNA for C11orf58 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C11orf58

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf58 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - -

Relevant External Links for C11orf58 Gene

GeneLoc Exon Structure for
C11orf58

Expression for C11orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf58 Gene

Protein differential expression in normal tissues from HIPED for C11orf58 Gene

This gene is overexpressed in Adrenal (47.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf58 Gene



Protein tissue co-expression partners for C11orf58 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C11orf58

SOURCE GeneReport for Unigene cluster for C11orf58 Gene:

Hs.645792

Evidence on tissue expression from TISSUES for C11orf58 Gene

  • Nervous system(4.7)
  • Lung(3.8)
  • Kidney(3.6)
  • Skin(3.4)
  • Thyroid gland(2.4)
  • Liver(2.3)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with C11orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C11orf58 Gene

Orthologs for C11orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf58 30
  • 100 (n)
dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
C21H11orf58 30
  • 93.77 (n)
-- 31
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SMAP 31
  • 98 (a)
OneToOne
C15H11orf58 30
  • 93 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf58 31
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf58 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110004F10Rik 17 31 30
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311703 30
  • 85.27 (n)
chicken
(Gallus gallus)
Aves C5H11ORF58 31 30
  • 77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf58 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf58 30
  • 58.38 (n)
Str.5966 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.18476 30
zebrafish
(Danio rerio)
Actinopterygii zgc:56106 30
  • 71.09 (n)
C18H11orf58 31
  • 55 (a)
OneToOne
zgc56106 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5834 30
Species where no ortholog for C11orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf58 Gene

ENSEMBL:
Gene Tree for C11orf58 (if available)
TreeFam:
Gene Tree for C11orf58 (if available)

Paralogs for C11orf58 Gene

(2) SIMAP similar genes for C11orf58 Gene using alignment to 5 proteins:

  • E3W975_HUMAN
  • E9PM92_HUMAN
  • E9PQA1_HUMAN
  • E9PRZ9_HUMAN
  • L8E8H2_HUMAN

Pseudogenes.org Pseudogenes for C11orf58 Gene

genes like me logo Genes that share paralogs with C11orf58: view

No data available for Paralogs for C11orf58 Gene

Variants for C11orf58 Gene

Additional dbSNP identifiers (rs#s) for C11orf58 Gene

Structural Variations from Database of Genomic Variants (DGV) for C11orf58 Gene

Variant ID Type Subtype PubMed ID
esv23566 CNV loss 19812545
esv2571561 CNV deletion 19546169
nsv553566 CNV gain 21841781

Variation tolerance for C11orf58 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C11orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C11orf58 Gene

Disorders for C11orf58 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C11orf58 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ataxia, sensory, 1, autosomal dominant
  • snax1
gaucher's disease
  • glucocerebrosidase deficiency
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C11orf58

genes like me logo Genes that share disorders with C11orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C11orf58 Gene

Publications for C11orf58 Gene

  1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. (PMID: 9263035) Gong TW … Lomax MI (International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1997) 2 3 4 23 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for C11orf58 Gene

Sources for C11orf58 Gene