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Aliases for C10orf99 Gene

Aliases for C10orf99 Gene

  • Chromosome 10 Open Reading Frame 99 2 3 5
  • Colon-Derived SUSD2 Binding Factor 2 3 4
  • Anti-Microbial Peptide With 57 Amino Acid Residues 2 3
  • Secreted Protein C10orf99 3 4
  • Antimicrobial Peptide-57 3 4
  • GPR15L 3 4
  • AP-57 3 4
  • CSBF 3 4
  • Protein GPR15L 3
  • RLLV1833 3
  • UNQ1833 3
  • AP57 3

External Ids for C10orf99 Gene

Previous GeneCards Identifiers for C10orf99 Gene

  • GC10P085590
  • GC10P085923
  • GC10P079779

Summaries for C10orf99 Gene

GeneCards Summary for C10orf99 Gene

C10orf99 (Chromosome 10 Open Reading Frame 99) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity.

UniProtKB/Swiss-Prot for C10orf99 Gene

  • Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403).

  • Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).

Additional gene information for C10orf99 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf99 Gene

Genomics for C10orf99 Gene

GeneHancer (GH) Regulatory Elements for C10orf99 Gene

Promoters and enhancers for C10orf99 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I084171 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 550.8 -1.0 -974 2.8 HDGF PKNOX1 SMAD1 RB1 BACH1 PAX8 EBF1 POLR2A NFATC1 ATF7 CERNA2 C10orf99 CDHR1 LRIT2
GH10I084174 Enhancer 0.2 dbSUPER 550.8 +1.1 1108 0.3 C10orf99 GC10P084182
GH10I084137 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 4.5 -34.3 -34337 4.2 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 NBN GHITM ENSG00000271933 RPS3AP5 CDHR1 C10orf99 GC10M084047
GH10I084156 Enhancer 1 Ensembl ENCODE 5 -16.7 -16710 0.8 CTCF HDAC1 MEIS2 PKNOX1 ETV1 JUN MAX CEBPG ZIC2 FOSL1 CDHR1 LRIT2 RNU1-65P ENSG00000271933 C10orf99 CERNA2
GH10I084159 Enhancer 0.2 dbSUPER 7.8 -14.4 -14409 0.6 CDHR1 LRIT2 LRIT1 RNU1-65P C10orf99 CERNA2 ENSG00000271933
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf99 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf99 gene promoter:

Genomic Locations for C10orf99 Gene

Genomic Locations for C10orf99 Gene
chr10:84,173,738-84,185,294
(GRCh38/hg38)
Size:
11,557 bases
Orientation:
Plus strand
chr10:85,933,494-85,945,050
(GRCh37/hg19)

Genomic View for C10orf99 Gene

Genes around C10orf99 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf99 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf99 Gene

Proteins for C10orf99 Gene

  • Protein details for C10orf99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWK7-GP15L_HUMAN
    Recommended name:
    Protein GPR15L
    Protein Accession:
    Q6UWK7

    Protein attributes for C10orf99 Gene

    Size:
    81 amino acids
    Molecular mass:
    9173 Da
    Quaternary structure:
    • Interacts with SUSD2; the interaction is direct.

neXtProt entry for C10orf99 Gene

Post-translational modifications for C10orf99 Gene

  • Glycosylation at Asn48
  • Modification sites at PhosphoSitePlus

Other Protein References for C10orf99 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf99 Gene

Domains & Families for C10orf99 Gene

Gene Families for C10orf99 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C10orf99 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf99: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf99 Gene

Function for C10orf99 Gene

Molecular function for C10orf99 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G-protein coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403).
UniProtKB/Swiss-Prot Function:
Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381).

Gene Ontology (GO) - Molecular Function for C10orf99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IDA 28900043
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 28936214
GO:0008009 chemokine activity IDA,IEA 28936214
GO:0048018 receptor ligand activity IDA 28900043
genes like me logo Genes that share ontologies with C10orf99: view

Phenotypes for C10orf99 Gene

genes like me logo Genes that share phenotypes with C10orf99: view

Animal Model Products

CRISPR Products

miRNA for C10orf99 Gene

miRTarBase miRNAs that target C10orf99

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf99 Gene

Localization for C10orf99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf99 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf99 gene
Compartment Confidence
extracellular 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for C10orf99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 25351403
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C10orf99: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C10orf99 Gene

Pathways & Interactions for C10orf99 Gene

SuperPathways for C10orf99 Gene

No Data Available

Interacting Proteins for C10orf99 Gene

Gene Ontology (GO) - Biological Process for C10orf99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IDA 28900043
GO:0010469 regulation of receptor activity IEA --
GO:0042742 defense response to bacterium IEA --
GO:0048247 lymphocyte chemotaxis IEA,IDA 28936214
GO:0050830 defense response to Gram-positive bacterium IDA 25585381
genes like me logo Genes that share ontologies with C10orf99: view

No data available for Pathways by source and SIGNOR curated interactions for C10orf99 Gene

Drugs & Compounds for C10orf99 Gene

No Compound Related Data Available

Transcripts for C10orf99 Gene

mRNA/cDNA for C10orf99 Gene

Unigene Clusters for C10orf99 Gene

Chromosome 10 open reading frame 99:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf99 Gene

No ASD Table

Relevant External Links for C10orf99 Gene

GeneLoc Exon Structure for
C10orf99
ECgene alternative splicing isoforms for
C10orf99

Expression for C10orf99 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf99 Gene

This gene is overexpressed in Colon - Transverse (x18.9), Esophagus - Mucosa (x12.9), and Vagina (x6.8).

NURSA nuclear receptor signaling pathways regulating expression of C10orf99 Gene:

C10orf99

SOURCE GeneReport for Unigene cluster for C10orf99 Gene:

Hs.298713

mRNA Expression by UniProt/SwissProt for C10orf99 Gene:

Q6UWK7-GP15L_HUMAN
Tissue specificity: Expressed at high levels in colon, and cervix and at moderate level in tonsil (PubMed:25585381, PubMed:28900043). Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381).

Evidence on tissue expression from TISSUES for C10orf99 Gene

  • Intestine(2.5)
genes like me logo Genes that share expression patterns with C10orf99: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf99 Gene

Orthologs for C10orf99 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for C10orf99 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf99 33
  • 100 (n)
C10orf99 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610528A11Rik 34
  • 56 (a)
OneToOne
Species where no ortholog for C10orf99 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf99 Gene

ENSEMBL:
Gene Tree for C10orf99 (if available)
TreeFam:
Gene Tree for C10orf99 (if available)

Paralogs for C10orf99 Gene

No data available for Paralogs for C10orf99 Gene

Variants for C10orf99 Gene

Sequence variations from dbSNP and Humsavar for C10orf99 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000079384 -- 84,174,180(+) A/G intron_variant
rs1000456378 -- 84,173,063(+) C/T upstream_transcript_variant
rs1000619845 -- 84,174,477(+) G/A intron_variant
rs1000830441 -- 84,178,125(+) C/A/T intron_variant
rs1000938719 -- 84,182,886(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf99 Gene

Variant ID Type Subtype PubMed ID
esv3367444 CNV duplication 20981092
nsv1046749 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv472451 CNV novel sequence insertion 20440878
nsv551745 CNV gain 21841781

Variation tolerance for C10orf99 Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf99 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf99 Gene

Disorders for C10orf99 Gene

Additional Disease Information for C10orf99

No disorders were found for C10orf99 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf99 Gene

Publications for C10orf99 Gene

  1. AP-57/C10orf99 is a new type of multifunctional antimicrobial peptide. (PMID: 25585381) Yang M … Tong A (Biochemical and biophysical research communications 2015) 2 3 4 58
  2. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. (PMID: 25351403) Pan W … Han W (Scientific reports 2014) 2 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  4. A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. (PMID: 28900043) Suply T … Bassilana F (Science signaling 2017) 3 4 58
  5. A Mucosal and Cutaneous Chemokine Ligand for the Lymphocyte Chemoattractant Receptor GPR15. (PMID: 28936214) Ocón B … Butcher EC (Frontiers in immunology 2017) 3 4 58

Products for C10orf99 Gene

Sources for C10orf99 Gene

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