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Aliases for C10orf76 Gene

Aliases for C10orf76 Gene

  • Chromosome 10 Open Reading Frame 76 2 3 5

External Ids for C10orf76 Gene

Previous GeneCards Identifiers for C10orf76 Gene

  • GC10M103270
  • GC10M103595
  • GC10M097236

Summaries for C10orf76 Gene

GeneCards Summary for C10orf76 Gene

C10orf76 (Chromosome 10 Open Reading Frame 76) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding.

Additional gene information for C10orf76 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf76 Gene

Genomics for C10orf76 Gene

GeneHancer (GH) Regulatory Elements for C10orf76 Gene

Promoters and enhancers for C10orf76 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I102054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 554.6 +0.6 594 2.5 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 C10orf76 KCNIP2 ENSG00000222430
GH10I102057 Enhancer 0.9 ENCODE 550.8 -1.9 -1930 0.9 ATF1 FOXA2 ARNT ARID4B DMAP1 POLR2B ZNF766 ATF7 ZNF592 NFIL3 C10orf76 HPS6
GH10I102051 Promoter 0.6 EPDnew 550.8 +4.7 4699 0.1 PRDM10 C10orf76 ENSG00000222430
GH10I102916 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -862.4 -862417 4.3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 CNNM2 AS3MT PDCD11 GBF1 TAF5 PPRC1 C10orf76 ENSG00000260461 LDB1 MARCKSL1P1
GH10I101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10 +361.9 361885 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 TWNK SUFU LZTS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf76 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf76 gene promoter:

Genomic Locations for C10orf76 Gene

Genomic Locations for C10orf76 Gene
210,634 bases
Minus strand

Genomic View for C10orf76 Gene

Genes around C10orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf76 Gene

Proteins for C10orf76 Gene

  • Protein details for C10orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0668 protein C10orf76
    Protein Accession:
    Secondary Accessions:
    • Q2TB87
    • Q9H8Z9

    Protein attributes for C10orf76 Gene

    689 amino acids
    Molecular mass:
    78710 Da
    Quaternary structure:
    • Interacts with PI4KB.

    Alternative splice isoforms for C10orf76 Gene


neXtProt entry for C10orf76 Gene

Post-translational modifications for C10orf76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf76 Gene

Domains & Families for C10orf76 Gene

Gene Families for C10orf76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf76 Gene

Suggested Antigen Peptide Sequences for C10orf76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0668 family.
  • Belongs to the UPF0668 family.
genes like me logo Genes that share domains with C10orf76: view

Function for C10orf76 Gene

Phenotypes From GWAS Catalog for C10orf76 Gene

Gene Ontology (GO) - Molecular Function for C10orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23572552
genes like me logo Genes that share ontologies with C10orf76: view
genes like me logo Genes that share phenotypes with C10orf76: view

Animal Models for C10orf76 Gene

MGI Knock Outs for C10orf76:

Animal Model Products

CRISPR Products

miRNA for C10orf76 Gene

miRTarBase miRNAs that target C10orf76

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C10orf76 Gene

Localization for C10orf76 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf76 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf76 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C10orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf76: view

Pathways & Interactions for C10orf76 Gene

SuperPathways for C10orf76 Gene

No Data Available

Interacting Proteins for C10orf76 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359050 Q5T2E6-CJ076_HUMAN for C10orf76 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C10orf76 Gene


No data available for Pathways by source and SIGNOR curated interactions for C10orf76 Gene

Drugs & Compounds for C10orf76 Gene

No Compound Related Data Available

Transcripts for C10orf76 Gene

Unigene Clusters for C10orf76 Gene

Chromosome 10 open reading frame 76:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf76 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP3: - -
SP5: - - -

Relevant External Links for C10orf76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C10orf76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf76 Gene

Protein differential expression in normal tissues from HIPED for C10orf76 Gene

This gene is overexpressed in Cervix (16.5), Peripheral blood mononuclear cells (9.1), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C10orf76 Gene

Protein tissue co-expression partners for C10orf76 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf76 Gene:


SOURCE GeneReport for Unigene cluster for C10orf76 Gene:


Evidence on tissue expression from TISSUES for C10orf76 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with C10orf76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf76 Gene

Orthologs for C10orf76 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C10orf76 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C10orf76 34
  • 100 (a)
C26H10orf76 33
  • 95.21 (n)
(Canis familiaris)
Mammalia C10orf76 34
  • 100 (a)
C28H10orf76 33
  • 94.82 (n)
(Pan troglodytes)
Mammalia C10orf76 34
  • 100 (a)
C10H10orf76 33
  • 99.9 (n)
(Monodelphis domestica)
Mammalia C10orf76 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf76 34
  • 93 (a)
(Mus musculus)
Mammalia 9130011E15Rik 33 16 34
  • 91.39 (n)
(Rattus norvegicus)
Mammalia RGD1564887 33
  • 91.39 (n)
(Gallus gallus)
Aves C10orf76 34
  • 96 (a)
C6H10ORF76 33
  • 82.54 (n)
(Anolis carolinensis)
Reptilia C10orf76 34
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488528 33
  • 79.25 (n)
Str.10588 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.32918 33
(Danio rerio)
Actinopterygii C22H10orf76 (1 of 2) 34
  • 85 (a)
C22H10orf76 (2 of 2) 34
  • 82 (a)
zgc:63733 33
  • 74.94 (n)
zgc63733 33
fruit fly
(Drosophila melanogaster)
Insecta CG8379 33 34
  • 55.59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012485 33
  • 50.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08708 33
  • 42.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC20F10.02c 33
  • 38.32 (n)
Species where no ortholog for C10orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf76 Gene

Gene Tree for C10orf76 (if available)
Gene Tree for C10orf76 (if available)

Paralogs for C10orf76 Gene

No data available for Paralogs for C10orf76 Gene

Variants for C10orf76 Gene

Sequence variations from dbSNP and Humsavar for C10orf76 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000029857 -- 101,971,304(-) C/T intron_variant
rs1000060749 -- 101,912,249(-) C/T intron_variant
rs1000061344 -- 101,958,126(-) C/T intron_variant
rs1000061739 -- 102,026,111(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000075626 -- 102,045,211(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf76 Gene

Variant ID Type Subtype PubMed ID
esv1400220 CNV insertion 17803354
esv3309100 CNV mobile element insertion 20981092
esv3329487 CNV insertion 20981092
esv3338570 CNV insertion 20981092
esv3346415 CNV insertion 20981092
esv3414712 CNV insertion 20981092
esv3450028 CNV duplication 20981092
esv3624392 CNV loss 21293372
nsv472440 CNV novel sequence insertion 20440878
nsv479391 CNV novel sequence insertion 20440878
nsv513016 CNV insertion 21212237

Variation tolerance for C10orf76 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf76 Gene

Disorders for C10orf76 Gene

Additional Disease Information for C10orf76

No disorders were found for C10orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf76 Gene

Publications for C10orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. (PMID: 23572552) Greninger AL … DeRisi JL (mBio 2013) 3 4 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. Gene essentiality and synthetic lethality in haploid human cells. (PMID: 26472760) Blomen VA … Brummelkamp TR (Science (New York, N.Y.) 2015) 3 58
  5. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld CA … Koellinger PD (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58

Products for C10orf76 Gene

Sources for C10orf76 Gene

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