Aliases for C10orf67 Gene

Aliases for C10orf67 Gene

  • Chromosome 10 Open Reading Frame 67 2 3 5
  • Uncharacterized Protein C10orf67, Mitochondrial 3 4
  • Long Intergenic Non-Protein Coding RNA 1552 2 3
  • LINC01552 3 4
  • Chromosome 10 Open Reading Frame 115 2
  • C10orf115 3

External Ids for C10orf67 Gene

Previous HGNC Symbols for C10orf67 Gene

  • LINC01552
  • C10orf115

Previous GeneCards Identifiers for C10orf67 Gene

  • GC10M023609
  • GC10M023645
  • GC10M023556
  • GC10M023265

Summaries for C10orf67 Gene

GeneCards Summary for C10orf67 Gene

C10orf67 (Chromosome 10 Open Reading Frame 67) is a Protein Coding gene.

Additional gene information for C10orf67 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C10orf67 Gene

Genomics for C10orf67 Gene

GeneHancer (GH) Regulatory Elements for C10orf67 Gene

Promoters and enhancers for C10orf67 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J023343 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 508.2 +0.1 149 3.6 EP300 ZSCAN5C JUND FOS ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 TRIM28 C10orf67 ENSG00000224215 LOC105376453
GH10J023363 Enhancer 1.1 FANTOM5 Ensembl ENCODE 19.6 -21.3 -21284 9 ZNF623 ATF2 TCF12 FOS SRF MEF2B SPI1 BATF IRF4 EBF1 C10orf67 ENSG00000224215 HSALNG0076691
GH10J023412 Enhancer 1.2 FANTOM5 Ensembl ENCODE 17.2 -68.2 -68185 4 ZNF639 EP300 MEF2C ZEB1 BCL11A CBFB FOS RFX5 CEBPB MEF2B C10orf67 OTUD1 ENSG00000224215 ENSG00000227537 piR-41306-028 RF01210-046
GH10J023511 Enhancer 1.1 FANTOM5 ENCODE 10.3 -167.4 -167398 1.6 JUND TRIM28 RFX1 EP300 CTBP1 JUN MYC NFRKB FOSL1 GABPA piR-57176-058 piR-58308-035 OTUD1 C10orf67 ENSG00000224215 KIAA1217 LOC105376454 ENSG00000287124
GH10J023431 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.4 -87.6 -87585 4 POLR2A CEBPB STAT3 KLF1 SPI1 FOS ZNF770 OTUD1 C10orf67 ENSG00000224215 lnc-C10orf67-1 HSALNG0076698
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C10orf67 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C10orf67

Top Transcription factor binding sites by QIAGEN in the C10orf67 gene promoter:
  • AML1a
  • Cart-1
  • E47
  • Hand1
  • Hlf
  • Nkx6-1
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • TBP

Genomic Locations for C10orf67 Gene

Genomic Locations for C10orf67 Gene
chr10:23,201,916-23,345,216
(GRCh38/hg38)
Size:
143,301 bases
Orientation:
Minus strand
chr10:23,556,124-23,633,774
(GRCh37/hg19)
Size:
77,651 bases
Orientation:
Minus strand

Genomic View for C10orf67 Gene

Genes around C10orf67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf67 Gene

Proteins for C10orf67 Gene

  • Protein details for C10orf67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ2-CJ067_HUMAN
    Recommended name:
    Uncharacterized protein C10orf67, mitochondrial
    Protein Accession:
    Q8IYJ2
    Secondary Accessions:
    • A8MUP9
    • Q5QP74
    • Q5SWD4

    Protein attributes for C10orf67 Gene

    Size:
    551 amino acids
    Molecular mass:
    63656 Da
    Quaternary structure:
    • Interacts with NOD2.
    SequenceCaution:
    • Sequence=AAH35732.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for C10orf67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf67 Gene

Post-translational modifications for C10orf67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf67 Gene

Domains & Families for C10orf67 Gene

Gene Families for C10orf67 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf67 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C10orf67: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C10orf67 Gene

Function for C10orf67 Gene

Phenotypes From GWAS Catalog for C10orf67 Gene

Gene Ontology (GO) - Molecular Function for C10orf67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27812135
genes like me logo Genes that share ontologies with C10orf67: view

Phenotypes for C10orf67 Gene

genes like me logo Genes that share phenotypes with C10orf67: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf67 Gene

Localization for C10orf67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf67 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf67 gene
Compartment Confidence
mitochondrion 4
peroxisome 1
nucleus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C10orf67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C10orf67: view

Pathways & Interactions for C10orf67 Gene

PathCards logo

SuperPathways for C10orf67 Gene

No Data Available

Interacting Proteins for C10orf67 Gene

;

Gene Ontology (GO) - Biological Process for C10orf67 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf67 Gene

Drugs & Compounds for C10orf67 Gene

No Compound Related Data Available

Transcripts for C10orf67 Gene

mRNA/cDNA for C10orf67 Gene

4 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf67 Gene

No ASD Table

Relevant External Links for C10orf67 Gene

GeneLoc Exon Structure for
C10orf67

Expression for C10orf67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C10orf67 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf67 Gene

This gene is overexpressed in Testis (x12.7), Pituitary (x4.7), and Lung (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf67 Gene



Protein tissue co-expression partners for C10orf67 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C10orf67

SOURCE GeneReport for Unigene cluster for C10orf67 Gene:

Hs.522360

Evidence on tissue expression from TISSUES for C10orf67 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with C10orf67: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf67 Gene

Orthologs for C10orf67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf67 30
  • 99.64 (n)
C10orf67 31
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10orf67 31
  • 35 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10orf67 31
  • 17 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf67 31
  • 16 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4921504E06Rik 31
  • 14 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf67 31
  • 12 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10orf67 31
  • 11 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf67 31
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C2H10orf67 31
  • 8 (a)
OneToOne
Species where no ortholog for C10orf67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf67 Gene

ENSEMBL:
Gene Tree for C10orf67 (if available)
TreeFam:
Gene Tree for C10orf67 (if available)

Paralogs for C10orf67 Gene

No data available for Paralogs for C10orf67 Gene

Variants for C10orf67 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C10orf67 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs116846325 Benign: Diabetes mellitus type 2 23,259,604(-) C/A INTRON_VARIANT
rs1554804525 Benign: Diabetes mellitus type 2 23,233,560(-) C/T INTRON_VARIANT
rs4454613 Benign: Diabetes mellitus type 2 23,283,453(-) A/C INTRON_VARIANT
rs7090683 Benign: Diabetes mellitus type 2 23,290,495(-) G/A INTRON_VARIANT
rs7904665 Benign: Diabetes mellitus type 2 23,255,343(-) T/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for C10orf67 Gene

Structural Variations from Database of Genomic Variants (DGV) for C10orf67 Gene

Variant ID Type Subtype PubMed ID
nsv1069463 CNV deletion 25765185
nsv1143495 CNV deletion 24896259
nsv550213 CNV loss 21841781
nsv550213 CNV loss 21841781
nsv6043 CNV insertion 18451855
nsv825301 CNV gain 20364138
nsv825302 CNV gain 20364138
nsv831810 CNV gain 17160897
nsv951256 CNV duplication 24416366

Variation tolerance for C10orf67 Gene

Gene Damage Index Score: 3.94; 59.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf67 Gene

Disorders for C10orf67 Gene

Additional Disease Information for C10orf67

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C10orf67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf67 Gene

Publications for C10orf67 Gene

  1. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. (PMID: 27812135) Thiébaut R … Ollendorff V (PloS one 2016) 2 3 4 54
  2. Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. (PMID: 18723019) Franke A … Schreiber S (Gastroenterology 2008) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C10orf67 Gene

Sources for C10orf67 Gene