Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C10orf55 Gene

Aliases for C10orf55 Gene

  • Chromosome 10 Open Reading Frame 55 2 3 5
  • Uncharacterized Protein C10orf55 3

External Ids for C10orf55 Gene

Previous GeneCards Identifiers for C10orf55 Gene

  • GC10U900528
  • GC10M075340
  • GC10M075669
  • GC10M069664

Summaries for C10orf55 Gene

GeneCards Summary for C10orf55 Gene

C10orf55 (Chromosome 10 Open Reading Frame 55) is a Protein Coding gene. Diseases associated with C10orf55 include Quebec Platelet Disorder and Hirschsprung Disease 1.

Additional gene information for C10orf55 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf55 Gene

Genomics for C10orf55 Gene

GeneHancer (GH) Regulatory Elements for C10orf55 Gene

Promoters and enhancers for C10orf55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J073923 Promoter 0.6 EPDnew 650.7 0.0 -20 0.1 ZSCAN5C C10orf55 GC10P073930
GH10J073922 Enhancer 0.5 ENCODE 650.7 +0.6 599 0.2 CBFB NR2F1 EED IKZF1 IKZF2 RUNX3 C10orf55 PLAU
GH10J073924 Enhancer 0.4 ENCODE 650.7 -1.4 -1381 0.2 PRDM10 ATF7 C10orf55 FUT11 GC10P073930
GH10J073964 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.7 -44.4 -44422 6.2 PKNOX1 SIN3A FEZF1 ZNF2 ETS1 GTF3C2 GLIS2 ZNF213 ZFP91 ATF7 SEC24C GLUD1P3 ENSG00000272140 DUSP8P5 AP3M1 ENSG00000242288 ECD ZSWIM8 RPL17P50 DNAJC9
GH10J073996 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 -76.5 -76491 4.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B VCL ECD AP3M1 SEC24C ZSWIM8 GLUD1P3 ZSWIM8-AS1 NDST2 DUSP8P5 RPL17P50
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf55 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf55 gene promoter:

Genomic Locations for C10orf55 Gene

Genomic Locations for C10orf55 Gene
chr10:73,909,969-73,922,777
(GRCh38/hg38)
Size:
12,809 bases
Orientation:
Minus strand
chr10:75,669,727-75,682,535
(GRCh37/hg19)

Genomic View for C10orf55 Gene

Genes around C10orf55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf55 Gene

Proteins for C10orf55 Gene

  • Protein details for C10orf55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SWW7-CJ055_HUMAN
    Recommended name:
    Uncharacterized protein C10orf55
    Protein Accession:
    Q5SWW7
    Secondary Accessions:
    • Q3KRG4
    • Q8NAK4

    Protein attributes for C10orf55 Gene

    Size:
    151 amino acids
    Molecular mass:
    16057 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03908.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C10orf55 Gene

Post-translational modifications for C10orf55 Gene

No Post-translational modifications

Other Protein References for C10orf55 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf55 Gene

Domains & Families for C10orf55 Gene

Gene Families for C10orf55 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf55 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf55: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf55 Gene

Function for C10orf55 Gene

Phenotypes From GWAS Catalog for C10orf55 Gene

genes like me logo Genes that share phenotypes with C10orf55: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf55 Gene

Localization for C10orf55 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf55 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C10orf55 Gene

Pathways & Interactions for C10orf55 Gene

SuperPathways for C10orf55 Gene

No Data Available

Interacting Proteins for C10orf55 Gene

Selected Interacting proteins: Q5SWW7-CJ055_HUMAN for C10orf55 Gene via IID UniProtKB

Gene Ontology (GO) - Biological Process for C10orf55 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf55 Gene

Drugs & Compounds for C10orf55 Gene

No Compound Related Data Available

Transcripts for C10orf55 Gene

mRNA/cDNA for C10orf55 Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Unigene Clusters for C10orf55 Gene

Chromosome 10 open reading frame 55:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf55 Gene

No ASD Table

Relevant External Links for C10orf55 Gene

GeneLoc Exon Structure for
C10orf55
ECgene alternative splicing isoforms for
C10orf55

Expression for C10orf55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf55 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf55 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of C10orf55 Gene:

C10orf55

SOURCE GeneReport for Unigene cluster for C10orf55 Gene:

Hs.585453
genes like me logo Genes that share expression patterns with C10orf55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf55 Gene

Orthologs for C10orf55 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C10orf55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf55 33
  • 98.9 (n)
C10orf55 34
  • 97 (a)
OneToOne
Species where no ortholog for C10orf55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf55 Gene

ENSEMBL:
Gene Tree for C10orf55 (if available)
TreeFam:
Gene Tree for C10orf55 (if available)

Paralogs for C10orf55 Gene

No data available for Paralogs for C10orf55 Gene

Variants for C10orf55 Gene

Sequence variations from dbSNP and Humsavar for C10orf55 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1006081549 uncertain-significance, Quebec platelet disorder 73,917,196(-) C/T intron_variant
rs1030117500 uncertain-significance, Quebec platelet disorder 73,917,253(-) C/T intron_variant
rs1057481305 uncertain-significance, Quebec platelet disorder 73,917,465(-) A/G intron_variant
rs117134857 benign, Quebec platelet disorder 73,917,085(-) G/T intron_variant
rs140559980 likely-benign, Quebec platelet disorder 73,916,920(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf55 Gene

Variant ID Type Subtype PubMed ID
dgv46n21 CNV loss 19592680
nsv1035390 CNV loss 25217958
nsv521018 CNV gain 19592680
nsv825468 CNV gain 20364138

Variation tolerance for C10orf55 Gene

Gene Damage Index Score: 1.41; 27.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf55 Gene

Disorders for C10orf55 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C10orf55 Gene - From: GeneCards

Disorder Aliases PubMed IDs
quebec platelet disorder
  • qpd
hirschsprung disease 1
  • hirschsprung disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C10orf55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C10orf55: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf55 Gene

Publications for C10orf55 Gene

  1. The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. (PMID: 28301587) Hayward CP … Wilson MD (PloS one 2017) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C10orf55 Gene

Sources for C10orf55 Gene

Content
Loading form....