Aliases for C10orf53 Gene

Aliases for C10orf53 Gene

  • Chromosome 10 Open Reading Frame 53 2 3 5
  • UPF0728 Protein C10orf53 3 4
  • Em:AC069546.1 2
  • C10orf53 5

External Ids for C10orf53 Gene

Previous GeneCards Identifiers for C10orf53 Gene

  • GC10P050233
  • GC10P050557
  • GC10P050887
  • GC10P045152

Summaries for C10orf53 Gene

GeneCards Summary for C10orf53 Gene

C10orf53 (Chromosome 10 Open Reading Frame 53) is a Protein Coding gene. Diseases associated with C10orf53 include Uterine Corpus Endometrial Carcinoma.

Additional gene information for C10orf53 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C10orf53 Gene

Genomics for C10orf53 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C10orf53 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J049679 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 605.7 -0.2 -173 1 ZNF512 RFX1 PKNOX1 PATZ1 REST ZNF600 SOX6 MGA SP2 CBX3 C10orf53 TIMM23B-AGAP6 AGAP6 ERCC6 WASHC2A RNA5SP317 piR-35674-048 SLC18A3
GH10J049761 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +82.4 82350 1.6 SP1 HNRNPL CREB1 GATAD2A REST ZNF629 TFE3 NFKBIZ KDM1A ZNF7 OGDHL TIMM23B-AGAP6 AGAP6 ERCC6 WASHC2A RNA5SP317 RF02543-010 C10orf53
GH10J049701 Enhancer 0.7 Ensembl ENCODE 0.4 +21.8 21775 0.8 CTCF ZNF341 GLIS1 ZNF143 SMARCA4 RAD21 SIX5 MZF1 RF02543-010 OGDHL C10orf53
GH10J049690 Enhancer 0.5 ENCODE 0.4 +10.7 10719 0.2 KDM1A YY1 NANOG POLR2A EZH2 SP1 POU5F1 EGR1 OGDHL MAPK6P6 SLC18A3 CHAT RF02543-010 C10orf53
GH10J049612 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 0.2 -66.3 -66341 1 CTCF KDM1A EZH2 KLF9 SP2 KLF1 RAD21 GLIS2 CHAT NONHSAG005873.2 SLC18A3 piR-35674-048 C10orf53
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C10orf53 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C10orf53

Top Transcription factor binding sites by QIAGEN in the C10orf53 gene promoter:
  • FOXL1
  • Gfi-1
  • Ik-1
  • Msx-1
  • MZF-1
  • Pax-6
  • POU3F2
  • RORalpha1
  • Sp1
  • Spz1

Genomic Locations for C10orf53 Gene

Genomic Locations for C10orf53 Gene
chr10:49,679,651-49,710,261
(GRCh38/hg38)
Size:
30,611 bases
Orientation:
Plus strand
chr10:50,887,684-50,918,307
(GRCh37/hg19)
Size:
30,624 bases
Orientation:
Plus strand

Genomic View for C10orf53 Gene

Genes around C10orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf53 Gene

Proteins for C10orf53 Gene

  • Protein details for C10orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6V4-CJ053_HUMAN
    Recommended name:
    UPF0728 protein C10orf53
    Protein Accession:
    Q8N6V4
    Secondary Accessions:
    • A6NI81
    • A6NLE0
    • B9ZVK6

    Protein attributes for C10orf53 Gene

    Size:
    93 amino acids
    Molecular mass:
    10399 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C10orf53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf53 Gene

Post-translational modifications for C10orf53 Gene

No Post-translational modifications

Other Protein References for C10orf53 Gene

No data available for DME Specific Peptides for C10orf53 Gene

Domains & Families for C10orf53 Gene

Gene Families for C10orf53 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf53 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C10orf53 Gene

GenScript: Design optimal peptide antigens:
  • UPF0728 protein C10orf53 (CJ053_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6V4

UniProtKB/Swiss-Prot:

CJ053_HUMAN :
  • Belongs to the UPF0728 family.
Family:
  • Belongs to the UPF0728 family.
genes like me logo Genes that share domains with C10orf53: view

Function for C10orf53 Gene

Phenotypes From GWAS Catalog for C10orf53 Gene

genes like me logo Genes that share phenotypes with C10orf53: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C10orf53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf53 Gene

Localization for C10orf53 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf53 gene
Compartment Confidence
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
extracellular 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C10orf53 Gene

Pathways & Interactions for C10orf53 Gene

PathCards logo

SuperPathways for C10orf53 Gene

No Data Available

Interacting Proteins for C10orf53 Gene

Gene Ontology (GO) - Biological Process for C10orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf53 Gene

Drugs & Compounds for C10orf53 Gene

No Compound Related Data Available

Transcripts for C10orf53 Gene

mRNA/cDNA for C10orf53 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C10orf53

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf53 Gene

No ASD Table

Relevant External Links for C10orf53 Gene

GeneLoc Exon Structure for
C10orf53

Expression for C10orf53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C10orf53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf53 Gene

This gene is overexpressed in Testis (x47.0).

Protein differential expression in normal tissues from HIPED for C10orf53 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf53 Gene



Protein tissue co-expression partners for C10orf53 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C10orf53

SOURCE GeneReport for Unigene cluster for C10orf53 Gene:

Hs.131287
genes like me logo Genes that share expression patterns with C10orf53: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf53 Gene

Orthologs for C10orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf53 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C10orf53 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C28H10orf53 30
  • 87.1 (n)
C10orf53 31
  • 73 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C28H10orf53 30 31
  • 84.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700024G13Rik 30 17 31
  • 80.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC680885 30
  • 79.93 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia C10orf53 31
  • 57 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C10orf53 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485377 30
  • 64.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:153142 30
  • 60.51 (n)
C13H10orf53 31
  • 50 (a)
OneToOne
Species where no ortholog for C10orf53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C10orf53 Gene

ENSEMBL:
Gene Tree for C10orf53 (if available)
TreeFam:
Gene Tree for C10orf53 (if available)

Paralogs for C10orf53 Gene

No data available for Paralogs for C10orf53 Gene

Variants for C10orf53 Gene

Additional dbSNP identifiers (rs#s) for C10orf53 Gene

Structural Variations from Database of Genomic Variants (DGV) for C10orf53 Gene

Variant ID Type Subtype PubMed ID
nsv1042677 CNV loss 25217958

Variation tolerance for C10orf53 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C10orf53 Gene

Disorders for C10orf53 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C10orf53 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uterine corpus endometrial carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C10orf53

genes like me logo Genes that share disorders with C10orf53: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf53 Gene

Publications for C10orf53 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for C10orf53 Gene

Sources for C10orf53 Gene