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Aliases for C10orf53 Gene

Aliases for C10orf53 Gene

  • Chromosome 10 Open Reading Frame 53 2 3 5

External Ids for C10orf53 Gene

Previous GeneCards Identifiers for C10orf53 Gene

  • GC10P050233
  • GC10P050557
  • GC10P050887
  • GC10P045152

Summaries for C10orf53 Gene

GeneCards Summary for C10orf53 Gene

C10orf53 (Chromosome 10 Open Reading Frame 53) is a Protein Coding gene.

Additional gene information for C10orf53 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf53 Gene

Genomics for C10orf53 Gene

GeneHancer (GH) Regulatory Elements for C10orf53 Gene

Promoters and enhancers for C10orf53 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I049679 Promoter/Enhancer 1.3 EPDnew ENCODE 550.8 -0.1 -58 0.2 KLF17 ZNF335 ZNF766 GLIS2 EGR1 ATF7 EGR2 SP3 USF2 REST C10orf53 SLC18A3
GH10I049612 Promoter/Enhancer 1 EPDnew ENCODE 0.2 -66.6 -66586 0.1 CTCF KLF1 GLIS2 SP2 KLF9 EZH2 CHAT SLC18A3 GC10P049595 C10orf53
GH10I049690 Enhancer 0.5 ENCODE 0.4 +10.7 10732 0.2 SP1 POLR2A POU5F1 EZH2 OGDHL MAPK6PS6 CHAT SLC18A3 GC10M049685 C10orf53
GH10I049689 Enhancer 0.4 ENCODE 0.4 +10.4 10432 0.2 POLR2A EZH2 OGDHL MAPK6PS6 SLC18A3 CHAT C10orf53 GC10M049685
GH10I049701 Enhancer 0.5 ENCODE 0.3 +21.6 21572 0.2 CTCF GLIS1 ZNF341 ZNF143 MZF1 OGDHL GC10M049685 C10orf53
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf53 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf53 gene promoter:

Genomic Locations for C10orf53 Gene

Genomic Locations for C10orf53 Gene
chr10:49,679,638-49,710,261
(GRCh38/hg38)
Size:
30,624 bases
Orientation:
Plus strand
chr10:50,887,684-50,918,307
(GRCh37/hg19)

Genomic View for C10orf53 Gene

Genes around C10orf53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf53 Gene

Proteins for C10orf53 Gene

  • Protein details for C10orf53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6V4-CJ053_HUMAN
    Recommended name:
    UPF0728 protein C10orf53
    Protein Accession:
    Q8N6V4
    Secondary Accessions:
    • A6NI81
    • A6NLE0
    • B9ZVK6

    Protein attributes for C10orf53 Gene

    Size:
    93 amino acids
    Molecular mass:
    10399 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C10orf53 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf53 Gene

Post-translational modifications for C10orf53 Gene

No Post-translational modifications

Other Protein References for C10orf53 Gene

No data available for DME Specific Peptides for C10orf53 Gene

Domains & Families for C10orf53 Gene

Gene Families for C10orf53 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf53 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C10orf53 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6V4

UniProtKB/Swiss-Prot:

CJ053_HUMAN :
  • Belongs to the UPF0728 family.
Family:
  • Belongs to the UPF0728 family.
genes like me logo Genes that share domains with C10orf53: view

Function for C10orf53 Gene

Phenotypes From GWAS Catalog for C10orf53 Gene

Phenotypes for C10orf53 Gene

genes like me logo Genes that share phenotypes with C10orf53: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf53 Gene

Localization for C10orf53 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf53 gene
Compartment Confidence
peroxisome 2
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C10orf53 Gene

Pathways & Interactions for C10orf53 Gene

SuperPathways for C10orf53 Gene

No Data Available

Interacting Proteins for C10orf53 Gene

Gene Ontology (GO) - Biological Process for C10orf53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf53 Gene

Drugs & Compounds for C10orf53 Gene

No Compound Related Data Available

Transcripts for C10orf53 Gene

mRNA/cDNA for C10orf53 Gene

Unigene Clusters for C10orf53 Gene

Chromosome 10 open reading frame 53:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf53 Gene

No ASD Table

Relevant External Links for C10orf53 Gene

GeneLoc Exon Structure for
C10orf53
ECgene alternative splicing isoforms for
C10orf53

Expression for C10orf53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf53 Gene

This gene is overexpressed in Testis (x47.0).

Protein differential expression in normal tissues from HIPED for C10orf53 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf53 Gene



Protein tissue co-expression partners for C10orf53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf53 Gene:

C10orf53

SOURCE GeneReport for Unigene cluster for C10orf53 Gene:

Hs.131287
genes like me logo Genes that share expression patterns with C10orf53: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf53 Gene

Orthologs for C10orf53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10orf53 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C28H10orf53 33
  • 87.1 (n)
C10orf53 34
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf53 33 34
  • 84.23 (n)
mouse
(Mus musculus)
Mammalia 1700024G13Rik 33 16 34
  • 80.29 (n)
rat
(Rattus norvegicus)
Mammalia LOC680885 33
  • 79.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf53 34
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C10orf53 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485377 33
  • 64.52 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:153142 33
  • 60.51 (n)
C13H10orf53 34
  • 50 (a)
OneToOne
Species where no ortholog for C10orf53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C10orf53 Gene

ENSEMBL:
Gene Tree for C10orf53 (if available)
TreeFam:
Gene Tree for C10orf53 (if available)

Paralogs for C10orf53 Gene

No data available for Paralogs for C10orf53 Gene

Variants for C10orf53 Gene

Sequence variations from dbSNP and Humsavar for C10orf53 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000027292 -- 49,698,361(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000074469 -- 49,698,085(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000404546 -- 49,685,327(+) G/A intron_variant
rs1000433445 -- 49,697,059(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000463700 -- 49,684,946(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf53 Gene

Variant ID Type Subtype PubMed ID
nsv1042677 CNV loss 25217958

Variation tolerance for C10orf53 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf53 Gene

Disorders for C10orf53 Gene

Additional Disease Information for C10orf53

No disorders were found for C10orf53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf53 Gene

Publications for C10orf53 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for C10orf53 Gene

Sources for C10orf53 Gene

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