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Aliases for C10orf25 Gene

Aliases for C10orf25 Gene

  • Chromosome 10 Open Reading Frame 25 2 3 5

External Ids for C10orf25 Gene

Previous GeneCards Identifiers for C10orf25 Gene

  • GC10M044777
  • GC10M044809
  • GC10U900614
  • GC10M045493
  • GC10M042018

Summaries for C10orf25 Gene

GeneCards Summary for C10orf25 Gene

C10orf25 (Chromosome 10 Open Reading Frame 25) is a Protein Coding gene.

Additional gene information for C10orf25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf25 Gene

Genomics for C10orf25 Gene

GeneHancer (GH) Regulatory Elements for C10orf25 Gene

Promoters and enhancers for C10orf25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I044999 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 568.2 -0.1 -130 3.5 PKNOX1 ATF1 FOXA2 ARNT YY1 ZNF766 CBX5 E2F8 ELK1 ZNF207 C10orf25 ZNF22 PIR48571 PIR53385 PARGP1 WASHC2C ENSG00000273363 FAM21FP RASSF4 AGAP4
GH10I044971 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.8 +21.1 21067 16.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 DEPP1 PIR49011 C10orf25 ZNF22 TMEM72-AS1 RASSF4 FAM21FP ENSG00000223462 ENSG00000234504 WASHC2C
GH10I044957 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13 +37.1 37094 12.3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 RASSF4 WASHC2C TMEM72-AS1 ZNF22 AGAP4 C10orf25 ENSG00000223462 ENSG00000234504 TMEM72 CEP164P1
GH10I044989 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +7.0 6951 9.7 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 ARID2 ATF7 RUNX3 PAF1 C10orf25 ENSG00000223462 DEPP1 GC10M045017 PIR39907 PIR53874 RASSF4
GH10I045058 Enhancer 0.7 FANTOM5 ENCODE 28.2 -58.0 -57963 1.2 ZNF766 JUN HLF C10orf25 ZNF22 ALOX5 GC10P045056 GC10M045074 CEP164P1 ENSG00000277757
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf25 gene promoter:

Genomic Locations for C10orf25 Gene

Genomic Locations for C10orf25 Gene
chr10:44,993,932-45,000,910
(GRCh38/hg38)
Size:
6,979 bases
Orientation:
Minus strand
chr10:45,493,146-45,496,470
(GRCh37/hg19)

Genomic View for C10orf25 Gene

Genes around C10orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf25 Gene

Proteins for C10orf25 Gene

  • Protein details for C10orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T742-CJ025_HUMAN
    Recommended name:
    Uncharacterized protein C10orf25
    Protein Accession:
    Q5T742
    Secondary Accessions:
    • A1L424
    • Q96NM5

    Protein attributes for C10orf25 Gene

    Size:
    122 amino acids
    Molecular mass:
    14441 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C10orf25 Gene

Post-translational modifications for C10orf25 Gene

  • Glycosylation at posLast=4949
  • Modification sites at PhosphoSitePlus

Other Protein References for C10orf25 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C10orf25 Gene

Domains & Families for C10orf25 Gene

Protein Domains for C10orf25 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf25: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf25 Gene

Function for C10orf25 Gene

Phenotypes From GWAS Catalog for C10orf25 Gene

Phenotypes for C10orf25 Gene

genes like me logo Genes that share phenotypes with C10orf25: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf25 Gene

Localization for C10orf25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf25 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf25 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for C10orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C10orf25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C10orf25 Gene

Pathways & Interactions for C10orf25 Gene

SuperPathways for C10orf25 Gene

No Data Available

Interacting Proteins for C10orf25 Gene

Gene Ontology (GO) - Biological Process for C10orf25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf25 Gene

Drugs & Compounds for C10orf25 Gene

No Compound Related Data Available

Transcripts for C10orf25 Gene

mRNA/cDNA for C10orf25 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C10orf25 Gene

Chromosome 10 open reading frame 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf25 Gene

No ASD Table

Relevant External Links for C10orf25 Gene

GeneLoc Exon Structure for
C10orf25
ECgene alternative splicing isoforms for
C10orf25

Expression for C10orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf25 Gene

NURSA nuclear receptor signaling pathways regulating expression of C10orf25 Gene:

C10orf25

SOURCE GeneReport for Unigene cluster for C10orf25 Gene:

Hs.707791

Evidence on tissue expression from TISSUES for C10orf25 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with C10orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf25 Gene

Orthologs for C10orf25 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C10orf25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10orf25 34
  • 99 (a)
OneToOne
Species where no ortholog for C10orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf25 Gene

ENSEMBL:
Gene Tree for C10orf25 (if available)
TreeFam:
Gene Tree for C10orf25 (if available)

Paralogs for C10orf25 Gene

No data available for Paralogs for C10orf25 Gene

Variants for C10orf25 Gene

Sequence variations from dbSNP and Humsavar for C10orf25 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000016528 -- 44,994,275(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000084765 -- 44,995,747(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000231261 -- 45,002,882(-) T/C upstream_transcript_variant
rs1000242437 -- 45,000,756(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000523991 -- 44,999,087(-) G/T 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf25 Gene

Variant ID Type Subtype PubMed ID
esv3576560 CNV gain 25503493
esv3623079 CNV loss 21293372
esv3623080 CNV gain 21293372
nsv831846 CNV loss 17160897
nsv831848 CNV gain 17160897

Variation tolerance for C10orf25 Gene

Residual Variation Intolerance Score: 81.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf25 Gene

Disorders for C10orf25 Gene

Additional Disease Information for C10orf25

No disorders were found for C10orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf25 Gene

Publications for C10orf25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for C10orf25 Gene

Sources for C10orf25 Gene

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