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Aliases for C10orf128 Gene

Aliases for C10orf128 Gene

  • Chromosome 10 Open Reading Frame 128 2 3 5

External Ids for C10orf128 Gene

Previous GeneCards Identifiers for C10orf128 Gene

  • GC10M049707
  • GC10M050033
  • GC10M050362
  • GC10M044628

Summaries for C10orf128 Gene

GeneCards Summary for C10orf128 Gene

C10orf128 (Chromosome 10 Open Reading Frame 128) is a Protein Coding gene. Diseases associated with C10orf128 include Basal Cell Nevus Syndrome.

Additional gene information for C10orf128 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C10orf128 Gene

Genomics for C10orf128 Gene

GeneHancer (GH) Regulatory Elements for C10orf128 Gene

Promoters and enhancers for C10orf128 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I049186 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.7 -0.4 -420 4.8 HDGF PKNOX1 SMAD1 TCF12 POLR2B GATA2 E2F8 ZNF207 ZNF143 ATF7 C10orf128 LINC00843 AGAP6 ERCC6 WASHC2A RNA5SP317 GC10P049274
GH10I049183 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28 +4.1 4108 2.6 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 ARID2 ATF7 CAVIN1 C10orf128 FAM170B
GH10I049176 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +11.0 10952 1.9 HDGF ATF1 ARNT IRF4 GTF3C2 ZNF766 ZNF143 FOS ATF7 RUNX3 C10orf128 FAM170B
GH10I049309 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -121.6 -121641 1.5 BCOR ATF1 ZMYM3 EBF1 CBX1 IKZF1 CREB1 ZFP36 FOS IKZF2 DRGX C10orf128 C10orf71 C10orf71-AS1 GC10M049333
GH10I049163 Enhancer 1 FANTOM5 ENCODE dbSUPER 22.8 +24.7 24698 0.2 L3MBTL2 JUN ZNF592 FOSL1 SMARCA4 ZNF184 IKZF1 MLLT1 ZBTB33 FOS C10orf128 ENSG00000226576 FAM170B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C10orf128 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C10orf128 gene promoter:

Genomic Locations for C10orf128 Gene

Genomic Locations for C10orf128 Gene
chr10:49,154,724-49,188,585
(GRCh38/hg38)
Size:
33,862 bases
Orientation:
Minus strand
chr10:50,362,773-50,396,630
(GRCh37/hg19)

Genomic View for C10orf128 Gene

Genes around C10orf128 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf128 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf128 Gene

Proteins for C10orf128 Gene

  • Protein details for C10orf128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T292-CJ128_HUMAN
    Recommended name:
    Putative uncharacterized protein C10orf128
    Protein Accession:
    Q5T292
    Secondary Accessions:
    • A6XND2
    • Q5T289
    • Q5T291

    Protein attributes for C10orf128 Gene

    Size:
    105 amino acids
    Molecular mass:
    11325 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C10orf128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C10orf128 Gene

Post-translational modifications for C10orf128 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C10orf128 Gene

Domains & Families for C10orf128 Gene

Gene Families for C10orf128 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C10orf128 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C10orf128: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C10orf128 Gene

Function for C10orf128 Gene

Phenotypes From GWAS Catalog for C10orf128 Gene

Phenotypes for C10orf128 Gene

GenomeRNAi human phenotypes for C10orf128:
genes like me logo Genes that share phenotypes with C10orf128: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf128 Gene

Localization for C10orf128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf128 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf128 gene
Compartment Confidence
extracellular 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C10orf128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf128: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C10orf128 Gene

Pathways & Interactions for C10orf128 Gene

SuperPathways for C10orf128 Gene

No Data Available

Interacting Proteins for C10orf128 Gene

Gene Ontology (GO) - Biological Process for C10orf128 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf128 Gene

Drugs & Compounds for C10orf128 Gene

No Compound Related Data Available

Transcripts for C10orf128 Gene

Unigene Clusters for C10orf128 Gene

Chromosome 10 open reading frame 128:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf128 Gene

No ASD Table

Relevant External Links for C10orf128 Gene

GeneLoc Exon Structure for
C10orf128
ECgene alternative splicing isoforms for
C10orf128

Expression for C10orf128 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C10orf128 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C10orf128 Gene

This gene is overexpressed in Cervix (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf128 Gene



Protein tissue co-expression partners for C10orf128 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C10orf128 Gene:

C10orf128

SOURCE GeneReport for Unigene cluster for C10orf128 Gene:

Hs.385493

Evidence on tissue expression from TISSUES for C10orf128 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C10orf128: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf128 Gene

Orthologs for C10orf128 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C10orf128 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C28H10orf128 33
  • 79.37 (n)
C10orf128 34
  • 38 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf128 33
  • 79.05 (n)
C10orf128 34
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810011H11Rik 33 16 34
  • 77.3 (n)
rat
(Rattus norvegicus)
Mammalia RGD1561145 33
  • 74.11 (n)
chimpanzee
(Pan troglodytes)
Mammalia C10orf128 34
  • 74 (a)
OneToOne
Species where no ortholog for C10orf128 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf128 Gene

ENSEMBL:
Gene Tree for C10orf128 (if available)
TreeFam:
Gene Tree for C10orf128 (if available)

Paralogs for C10orf128 Gene

No data available for Paralogs for C10orf128 Gene

Variants for C10orf128 Gene

Sequence variations from dbSNP and Humsavar for C10orf128 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000016746 -- 49,170,116(-) C/G intron_variant
rs1000043776 -- 49,184,909(-) G/T intron_variant
rs1000095704 -- 49,165,708(-) C/G/T intron_variant
rs1000171562 -- 49,186,360(-) T/C intron_variant
rs1000230175 -- 49,176,968(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C10orf128 Gene

Variant ID Type Subtype PubMed ID
esv3623165 CNV loss 21293372
esv3623166 CNV gain 21293372
esv3623167 CNV gain 21293372
nsv1042677 CNV loss 25217958
nsv1113295 CNV deletion 24896259

Variation tolerance for C10orf128 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf128 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf128 Gene

Disorders for C10orf128 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C10orf128 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basal cell nevus syndrome
  • bcns
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C10orf128

genes like me logo Genes that share disorders with C10orf128: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf128 Gene

Publications for C10orf128 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 44 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for C10orf128 Gene

Sources for C10orf128 Gene

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