C10orf120 Gene (Protein Coding)

Chromosome 10 Open Reading Frame 120

GC10M122697
GIFtS:
26

Aliases for C10orf120 Gene

Aliases for C10orf120 Gene

  • Chromosome 10 Open Reading Frame 120 2 3 5
  • Uncharacterized Protein C10orf120 3 4
  • BA318C4.1 3

External Ids for C10orf120 Gene

Previous GeneCards Identifiers for C10orf120 Gene

  • GC10M123998
  • GC10M124447
  • GC10M118075

Summaries for C10orf120 Gene

GeneCards Summary for C10orf120 Gene

C10orf120 (Chromosome 10 Open Reading Frame 120) is a Protein Coding gene. An important paralog of this gene is GMCL2.

Additional gene information for C10orf120 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C10orf120 Gene

Genomics for C10orf120 Gene

GeneHancer (GH) Regulatory Elements for C10orf120 Gene

Promoters and enhancers for C10orf120 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J122699 Promoter 0.3 EPDnew 500.7 0.0 -20 0.1 C10orf120 DMBT1L1
GH10J122690 Enhancer 0.6 Ensembl ENCODE 0.4 +10.8 10760 1.4 NR2F2 CTCF RAD21 RXRA EZH2 SP1 C10orf120 LOC112577516
GH10J122701 Enhancer 0.2 Ensembl 0.7 -2.8 -2755 0.4 C10orf120 DMBT1L1
GH10J122708 Enhancer 0.2 Ensembl 0.4 -8.1 -8055 0.6 C10orf120 DMBT1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C10orf120 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C10orf120

Top Transcription factor binding sites by QIAGEN in the C10orf120 gene promoter:
  • aMEF-2
  • AML1a
  • AREB6
  • c-Myb
  • CUTL1
  • GATA-6
  • IRF-1
  • MEF-2
  • MEF-2A

Genomic Locations for C10orf120 Gene

Genomic Locations for C10orf120 Gene
chr10:122,697,709-122,699,846
(GRCh38/hg38)
Size:
2,138 bases
Orientation:
Minus strand
chr10:124,457,225-124,459,338
(GRCh37/hg19)
Size:
2,114 bases
Orientation:
Minus strand

Genomic View for C10orf120 Gene

Genes around C10orf120 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf120 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf120 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C10orf120 Gene

Proteins for C10orf120 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C10orf120 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SQS8-CJ120_HUMAN
    Recommended name:
    Uncharacterized protein C10orf120
    Protein Accession:
    Q5SQS8
    Secondary Accessions:
    • B2RU17

    Protein attributes for C10orf120 Gene

    Size:
    335 amino acids
    Molecular mass:
    39268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C10orf120 Gene

Protein Expression for C10orf120 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C10orf120 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C10orf120 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C10orf120 Gene

Domains & Families for C10orf120 Gene

Gene Families for C10orf120 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf120 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C10orf120: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C10orf120 Gene

Function for C10orf120 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with C10orf120: view

Animal Models for C10orf120 Gene

MGI Knock Outs for C10orf120:

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C10orf120 Gene

Localization for C10orf120 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf120 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C10orf120 Gene

Pathways & Interactions for C10orf120 Gene

PathCards logo

SuperPathways for C10orf120 Gene

No Data Available

Interacting Proteins for C10orf120 Gene

;

Gene Ontology (GO) - Biological Process for C10orf120 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf120 Gene

Drugs & Compounds for C10orf120 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C10orf120 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for C10orf120 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf120 Gene

No ASD Table

Relevant External Links for C10orf120 Gene

GeneLoc Exon Structure for
C10orf120

Expression for C10orf120 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C10orf120 Gene

mRNA expression in normal human tissues for C10orf120 Gene
mRNA expression by GTEx for C10orf120 GenemRNA expression by BioGPS for C10orf120 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C10orf120 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for C10orf120 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C10orf120 Gene



Protein tissue co-expression partners for C10orf120 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C10orf120

SOURCE GeneReport for Unigene cluster for C10orf120 Gene:

Hs.363649
genes like me logo Genes that share expression patterns with C10orf120: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf120 Gene

Orthologs for C10orf120 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C10orf120 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C10H10orf120 30
  • 99.1 (n)
C10orf120 31
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia C28H10orf120 30
  • 74.75 (n)
C10orf120 31
  • 62 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia C26H10orf120 31 30
  • 73.33 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia 4933402N03Rik 17 31 30
  • 65.93 (n)
rat
(Rattus norvegicus)
 Mammalia LOC499276 30
  • 65.74 (n)
oppossum
(Monodelphis domestica)
 Mammalia C10orf120 31
  • 46 (a)
 OneToOne
Species where no ortholog for C10orf120 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf120 Gene

ENSEMBL:
Gene Tree for C10orf120 (if available)
TreeFam:
Gene Tree for C10orf120 (if available)

Paralogs for C10orf120 Gene

Paralogs for C10orf120 Gene

genes like me logo Genes that share paralogs with C10orf120: view

Variants for C10orf120 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C10orf120 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs2947594 - p.Ala269Thr
rs41448048 - p.Thr20Lys

Additional dbSNP identifiers (rs#s) for C10orf120 Gene

Structural Variations from Database of Genomic Variants (DGV) for C10orf120 Gene

Variant ID Type Subtype PubMed ID
nsv509370 CNV insertion 20534489
nsv7584 CNV insertion 18451855

Variation tolerance for C10orf120 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.23; 62.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf120 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf120

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf120 Gene

Disorders for C10orf120 Gene

Additional Disease Information for C10orf120

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C10orf120 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C10orf120 Gene

Publications for C10orf120 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

ExternalLinks

View latest publications for C10orf120 gene in Mastermind

Products for C10orf120 Gene

Sources for C10orf120 Gene