Aliases for C10orf105 Gene

Aliases for C10orf105 Gene

  • Chromosome 10 Open Reading Frame 105 2 3 5
  • Uncharacterized Protein C10orf105 3 4

External Ids for C10orf105 Gene

Previous GeneCards Identifiers for C10orf105 Gene

  • GC10U900452
  • GC10M073142
  • GC10M073472
  • GC10M067465

Summaries for C10orf105 Gene

GeneCards Summary for C10orf105 Gene

C10orf105 (Chromosome 10 Open Reading Frame 105) is a Protein Coding gene. Diseases associated with C10orf105 include Pituitary Adenoma 5, Multiple Types and Deafness, Autosomal Recessive 12.

Additional gene information for C10orf105 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C10orf105 Gene

Genomics for C10orf105 Gene

GeneHancer (GH) Regulatory Elements for C10orf105 Gene

Promoters and enhancers for C10orf105 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J071734 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.7 +1.1 1142 4.1 ZSCAN5C ZIC2 TRIM28 MXI1 ZNF341 OSR2 ZBTB17 SPI1 BCOR ZBTB48 C10orf105 VSIR PSAP CDH23 lnc-C10orf105-3
GH10J071720 Promoter/Enhancer 1.2 EPDnew ENCODE CraniofacialAtlas dbSUPER 500.4 +18.0 17980 0.8 FOXK2 CHD1 SIN3A PRDM10 JUND ZBTB33 REST TCF7L2 EP300 SP1 C10orf105 VSIR lnc-C10orf105-3 CDH23
GH10J071739 Enhancer 0.3 ENCODE dbSUPER 500.7 -1.7 -1695 0.2 C10orf105 VSIR PSAP lnc-C10orf105-4 CDH23
GH10J071762 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.2 -32.2 -32166 14.1 HNRNPK ZBTB40 ZNF217 CTCF TCF12 SP1 GTF2E2 JUND PHF8 FOS VSIR CDH23 C10orf105 PSAP SPOCK2 lnc-C10orf105-4
GH10J071844 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.3 -111.1 -111121 8.1 HNRNPK ZSCAN5C SIN3A MYC NRF1 USF1 POLR2G JUND PHF8 FOS PSAP piR-51878-002 DNAJB12 VSIR C10orf105 ANAPC16 MICU1 DDIT4 RF00066-026 RNU7-38P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C10orf105 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C10orf105

Top Transcription factor binding sites by QIAGEN in the C10orf105 gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • Bach1
  • c-Ets-1
  • C/EBPalpha
  • MyoD
  • Pax-3
  • STAT5B

Genomic Locations for C10orf105 Gene

Genomic Locations for C10orf105 Gene
chr10:71,711,701-71,737,824
(GRCh38/hg38)
Size:
26,124 bases
Orientation:
Minus strand
chr10:73,471,458-73,497,581
(GRCh37/hg19)
Size:
26,124 bases
Orientation:
Minus strand

Genomic View for C10orf105 Gene

Genes around C10orf105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C10orf105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C10orf105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C10orf105 Gene

Proteins for C10orf105 Gene

  • Protein details for C10orf105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEF2-CJ105_HUMAN
    Recommended name:
    Uncharacterized protein C10orf105
    Protein Accession:
    Q8TEF2

    Protein attributes for C10orf105 Gene

    Size:
    133 amino acids
    Molecular mass:
    14519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C10orf105 Gene

Post-translational modifications for C10orf105 Gene

No Post-translational modifications

Other Protein References for C10orf105 Gene

No data available for DME Specific Peptides for C10orf105 Gene

Domains & Families for C10orf105 Gene

Gene Families for C10orf105 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C10orf105 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C10orf105: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C10orf105 Gene

Function for C10orf105 Gene

Phenotypes From GWAS Catalog for C10orf105 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C10orf105

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C10orf105 Gene

Localization for C10orf105 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C10orf105 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C10orf105 gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytosol 0

Gene Ontology (GO) - Cellular Components for C10orf105 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C10orf105: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C10orf105 Gene

Pathways & Interactions for C10orf105 Gene

PathCards logo

SuperPathways for C10orf105 Gene

No Data Available

Interacting Proteins for C10orf105 Gene

;

Gene Ontology (GO) - Biological Process for C10orf105 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C10orf105 Gene

Drugs & Compounds for C10orf105 Gene

No Compound Related Data Available

Transcripts for C10orf105 Gene

mRNA/cDNA for C10orf105 Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C10orf105

Alternative Splicing Database (ASD) splice patterns (SP) for C10orf105 Gene

No ASD Table

Relevant External Links for C10orf105 Gene

GeneLoc Exon Structure for
C10orf105

Expression for C10orf105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C10orf105 Gene

mRNA differential expression in normal tissues according to GTEx for C10orf105 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x7.7), Brain - Hypothalamus (x7.2), Brain - Nucleus accumbens (basal ganglia) (x6.3), Brain - Hippocampus (x5.8), Brain - Amygdala (x5.7), Whole Blood (x4.5), and Brain - Substantia nigra (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C10orf105

SOURCE GeneReport for Unigene cluster for C10orf105 Gene:

Hs.568788

Evidence on tissue expression from TISSUES for C10orf105 Gene

  • Spleen(4)
genes like me logo Genes that share expression patterns with C10orf105: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C10orf105 Gene

Orthologs for C10orf105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C10orf105 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf105 30
  • 99.75 (n)
C10orf105 31
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C28H10orf105 30
  • 86.45 (n)
C10orf105 31
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C4H10orf105 30
  • 82.79 (n)
C10orf105 31
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm17455 17 31 30
  • 74.48 (n)
rat
(Rattus norvegicus)
Mammalia LOC100361018 30
  • 73.96 (n)
lizard
(Anolis carolinensis)
Reptilia C10orf105 31
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492846 30
  • 62.11 (n)
Species where no ortholog for C10orf105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C10orf105 Gene

ENSEMBL:
Gene Tree for C10orf105 (if available)
TreeFam:
Gene Tree for C10orf105 (if available)

Paralogs for C10orf105 Gene

No data available for Paralogs for C10orf105 Gene

Variants for C10orf105 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C10orf105 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
560725 Uncertain Significance: Deafness, autosomal recessive 12 71,732,200(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
595710 Uncertain Significance: not provided 71,732,187(-) G/C MISSENSE_VARIANT,INTRON_VARIANT
596473 Uncertain Significance: not provided 71,732,198(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
636161 Uncertain Significance: Vitreoretinopathy 71,712,775(-) G/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
644005 Likely Pathogenic: not provided 71,734,236(-) GCA/TCT SPLICE_ACCEPTOR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for C10orf105 Gene

Structural Variations from Database of Genomic Variants (DGV) for C10orf105 Gene

Variant ID Type Subtype PubMed ID
nsv470963 CNV loss 18288195
nsv831910 CNV loss 17160897

Variation tolerance for C10orf105 Gene

Gene Damage Index Score: 2.07; 37.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C10orf105 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C10orf105

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C10orf105 Gene

Disorders for C10orf105 Gene

MalaCards: The human disease database

(5) MalaCards diseases for C10orf105 Gene - From: GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma 5, multiple types
  • pita5
deafness, autosomal recessive 12
  • dfnb12
rare genetic deafness
usher syndrome
  • retinitis pigmentosa-deafness syndrome
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C10orf105

genes like me logo Genes that share disorders with C10orf105: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C10orf105 Gene

Publications for C10orf105 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 4 54
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C10orf105 Gene

Sources for C10orf105 Gene