Aliases for BZW2 Gene

Aliases for BZW2 Gene

  • Basic Leucine Zipper And W2 Domains 2 2 3 5
  • Basic Leucine Zipper And W2 Domain-Containing Protein 2 3 4
  • HSPC028 3
  • MSTP017 3
  • MST017 3

External Ids for BZW2 Gene

Previous GeneCards Identifiers for BZW2 Gene

  • GC07P016330
  • GC07P016430
  • GC07P016458
  • GC07P016652
  • GC07P016572

Summaries for BZW2 Gene

GeneCards Summary for BZW2 Gene

BZW2 (Basic Leucine Zipper And W2 Domains 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is BZW1.

UniProtKB/Swiss-Prot Summary for BZW2 Gene

Gene Wiki entry for BZW2 Gene

Additional gene information for BZW2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BZW2 Gene

Genomics for BZW2 Gene

GeneHancer (GH) Regulatory Elements for BZW2 Gene

Promoters and enhancers for BZW2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J016643 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 508.3 +0.6 629 5.8 FOXK2 ZNF217 EP300 TCF12 NRF1 POLR2G SP1 BCLAF1 NONO GTF2E2 BZW2 ANKMY2 piR-55985-185
GH07J016660 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 509.8 +15.6 15621 3.3 NCOR1 JUND FOS MYC CTBP1 EP300 JUN TRIM25 TEAD1 TAF9B BZW2 ANKMY2 piR-55985-185
GH07J016666 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.5 +23.2 23156 5 ZNF217 CTCF ZSCAN5C TCF12 JUND FOS REST POLR2A ZBTB11 AFF1 BZW2 ANKMY2 TSPAN13 piR-55985-185 RF00017-6060
GH07J016739 Enhancer 1.2 Ensembl ENCODE 14.1 +96.5 96470 7.2 ZSCAN5C TCF12 RBAK FOS POLR2A AFF1 TRIM28 DNMT1 HES1 MYC BZW2 AGR2 ANKMY2 TSPAN13 RF00017-6061 piR-56038-011
GH07J016620 Enhancer 1 Ensembl ENCODE dbSUPER 11.8 -25.8 -25830 0.6 EP300 FOS MEF2C MEF2B BATF ATF2 JUNB CBX5 NFIC ATF7 ANKMY2 BZW2 piR-45651-003 LOC105375169
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BZW2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BZW2

Top Transcription factor binding sites by QIAGEN in the BZW2 gene promoter:
  • AP-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • MRF-2
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for BZW2 Gene

Genomic Locations for BZW2 Gene
chr7:16,646,131-16,706,523
(GRCh38/hg38)
Size:
60,393 bases
Orientation:
Plus strand
chr7:16,685,756-16,746,148
(GRCh37/hg19)
Size:
60,393 bases
Orientation:
Plus strand

Genomic View for BZW2 Gene

Genes around BZW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW2 Gene

Proteins for BZW2 Gene

  • Protein details for BZW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E2-BZW2_HUMAN
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2
    Protein Accession:
    Q9Y6E2
    Secondary Accessions:
    • A4D123
    • Q3B779
    • Q96JW5
    • Q9H3F7

    Protein attributes for BZW2 Gene

    Size:
    419 amino acids
    Molecular mass:
    48162 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07758.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BZW2 Gene

Post-translational modifications for BZW2 Gene

  • Ubiquitination at Lys117 and Lys232
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW2 Gene

Domains & Families for BZW2 Gene

Gene Families for BZW2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BZW2 Gene

Blocks:
  • eIF4-gamma/eIF5/eIF2-epsilon
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BZW2 Gene

GenScript: Design optimal peptide antigens:
  • Basic leucine zipper and W2 domain-containing protein 2 (BZW2_HUMAN)
  • BZW2 protein (Q05D83_HUMAN)
  • cDNA FLJ14931 fis, clone PLACE1009434 (Q96JW5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6E2

UniProtKB/Swiss-Prot:

BZW2_HUMAN :
  • Belongs to the BZW family.
Family:
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW2: view

Function for BZW2 Gene

Molecular function for BZW2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.

Phenotypes From GWAS Catalog for BZW2 Gene

Gene Ontology (GO) - Molecular Function for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25147208
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with BZW2: view
genes like me logo Genes that share phenotypes with BZW2: view

Animal Models for BZW2 Gene

MGI Knock Outs for BZW2:
  • Bzw2 Bzw2<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

miRNA for BZW2 Gene

miRTarBase miRNAs that target BZW2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BZW2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BZW2 Gene

Localization for BZW2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BZW2 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IDA 25468996
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with BZW2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW2 Gene

Pathways & Interactions for BZW2 Gene

PathCards logo

SuperPathways for BZW2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with BZW2: view

No data available for Pathways by source and SIGNOR curated interactions for BZW2 Gene

Drugs & Compounds for BZW2 Gene

No Compound Related Data Available

Transcripts for BZW2 Gene

mRNA/cDNA for BZW2 Gene

5 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BZW2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BZW2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - - - -
SP7: - - - - - - - - - - -
SP8:
SP9: - - -
SP10: -
SP11: - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - -

ExUns: 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for BZW2 Gene

GeneLoc Exon Structure for
BZW2

Expression for BZW2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BZW2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BZW2 Gene

This gene is overexpressed in Heart - Left Ventricle (x7.9) and Muscle - Skeletal (x5.4).

Protein differential expression in normal tissues from HIPED for BZW2 Gene

This gene is overexpressed in Bone (41.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BZW2 Gene



Protein tissue co-expression partners for BZW2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BZW2

SOURCE GeneReport for Unigene cluster for BZW2 Gene:

Hs.487635

Evidence on tissue expression from TISSUES for BZW2 Gene

  • Heart(4.5)
  • Muscle(4.4)
  • Bone marrow(4.3)
  • Blood(4.2)
  • Kidney(4.2)
  • Intestine(3.7)
  • Nervous system(3.7)
  • Lung(3.4)
genes like me logo Genes that share expression patterns with BZW2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BZW2 Gene

Orthologs for BZW2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BZW2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BZW2 31 30
  • 99.84 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 97 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BZW2 31 30
  • 95.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BZW2 31 30
  • 94.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Bzw2 17 31 30
  • 91.73 (n)
rat
(Rattus norvegicus)
Mammalia Bzw2 30
  • 91.57 (n)
oppossum
(Monodelphis domestica)
Mammalia BZW2 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves BZW2 31 30
  • 84.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BZW2 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw2 30
  • 79 (n)
zebrafish
(Danio rerio)
Actinopterygii bzw2 31 30
  • 74.94 (n)
OneToOne
zgc55580 30
fruit fly
(Drosophila melanogaster)
Insecta exba 31
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65220 30
  • 46.4 (n)
rice
(Oryza sativa)
Liliopsida Os11g0414000 30
  • 47.48 (n)
Species where no ortholog for BZW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW2 Gene

ENSEMBL:
Gene Tree for BZW2 (if available)
TreeFam:
Gene Tree for BZW2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BZW2: view image

Paralogs for BZW2 Gene

Paralogs for BZW2 Gene

(2) SIMAP similar genes for BZW2 Gene using alignment to 11 proteins:

  • BZW2_HUMAN
  • B5MCE7_HUMAN
  • B5MCH7_HUMAN
  • C9JF98_HUMAN
  • E7EMS9_HUMAN
  • E7ETZ4_HUMAN
  • E9PFD4_HUMAN
  • F8WDX8_HUMAN
  • Q05D83_HUMAN
  • Q75MG1_HUMAN
  • Q96JW5_HUMAN

Pseudogenes.org Pseudogenes for BZW2 Gene

genes like me logo Genes that share paralogs with BZW2: view

Variants for BZW2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BZW2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs35233079 - p.Asp44Ala

Additional dbSNP identifiers (rs#s) for BZW2 Gene

Structural Variations from Database of Genomic Variants (DGV) for BZW2 Gene

Variant ID Type Subtype PubMed ID
dgv11223n54 CNV loss 21841781
dgv11224n54 CNV loss 21841781
dgv1874e212 CNV loss 25503493
dgv6289n100 CNV gain 25217958
esv25168 CNV loss 19812545
esv2665677 CNV deletion 23128226
esv2764004 CNV loss 21179565
esv3541254 CNV deletion 23714750
esv3612403 CNV loss 21293372
nsv1028125 CNV gain 25217958
nsv437016 CNV loss 16327808
nsv475913 CNV novel sequence insertion 20440878
nsv517565 CNV loss 19592680
nsv606326 CNV loss 21841781
nsv606327 CNV loss 21841781
nsv606334 CNV loss 21841781
nsv606336 CNV loss 21841781
nsv606337 CNV loss 21841781
nsv606338 CNV gain 21841781
nsv830912 CNV gain 17160897

Variation tolerance for BZW2 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BZW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BZW2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BZW2 Gene

Disorders for BZW2 Gene

Additional Disease Information for BZW2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BZW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BZW2 Gene

Publications for BZW2 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for BZW2 Gene

Sources for BZW2 Gene