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Aliases for BZW1 Gene

Aliases for BZW1 Gene

  • Basic Leucine Zipper And W2 Domains 1 2 3 5
  • BZAP45 3 4
  • Basic Leucine Zipper And W2 Domain-Containing Protein 1 3
  • Putative Protein Product Of Nbla10236 3
  • Basic Leucine-Zipper Protein BZAP45 3
  • Protein Orf 4
  • Nbla10236 3
  • KIAA0005 4

External Ids for BZW1 Gene

Previous GeneCards Identifiers for BZW1 Gene

  • GC02P199893
  • GC02P200400
  • GC02P201640
  • GC02P201879
  • GC02P201501
  • GC02P201384
  • GC02P201675
  • GC02P193528

Summaries for BZW1 Gene

GeneCards Summary for BZW1 Gene

BZW1 (Basic Leucine Zipper And W2 Domains 1) is a Protein Coding gene. Diseases associated with BZW1 include Phlebotomus Fever. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is BZW2.

UniProtKB/Swiss-Prot for BZW1 Gene

  • Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Gene Wiki entry for BZW1 Gene

Additional gene information for BZW1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BZW1 Gene

Genomics for BZW1 Gene

GeneHancer (GH) Regulatory Elements for BZW1 Gene

Promoters and enhancers for BZW1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J200809 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.8 1761 5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A GC02M200809 LOC101927795 BZW1 ORC2 TYW5 LOC100420110 PPIL3 CASP10 CLK1 BICD1P1
GH02J200859 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +52.1 52145 6 HDGF PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 CLK1 ENSG00000252759 GC02M200864 PPIL3 ORC2 LOC100420110 TYW5 NIF3L1 BZW1 LOC101927795
GH02J200754 Enhancer 1.3 Ensembl ENCODE dbSUPER 15.6 -54.0 -54026 3.8 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 FOS BZW1 LOC101927795 AOX1 PPIL3 CASP8 ALS2CR12 GC02P200777 LINC01792 AOX2P GC02P200578
GH02J201114 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.2 +313.6 313622 19 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 CFLAR PPIL3 CLK1 ORC2 CASP10 CFLAR-AS1 CDK15 KCTD18 FAM126B LOC105373835
GH02J200525 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.1 -284.2 -284206 2 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 SGO2 ORC2 AOX1 LOC100420110 LOC101927795 BZW1 KCTD18 PIR55109
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BZW1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BZW1 gene promoter:
  • AML1a
  • TBP
  • c-Myb
  • Nkx6-1
  • HOXA5
  • HNF-1
  • HNF-1A
  • C/EBPalpha

Genomic Locations for BZW1 Gene

Genomic Locations for BZW1 Gene
16,745 bases
Plus strand
13,253 bases
Plus strand

Genomic View for BZW1 Gene

Genes around BZW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BZW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BZW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BZW1 Gene

Proteins for BZW1 Gene

  • Protein details for BZW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic leucine zipper and W2 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DLZ8
    • B4DWF7
    • Q14281
    • Q15394
    • Q9BUY0

    Protein attributes for BZW1 Gene

    419 amino acids
    Molecular mass:
    48043 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA02795.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BZW1 Gene


neXtProt entry for BZW1 Gene

Post-translational modifications for BZW1 Gene

  • Ubiquitination at Lys399, posLast=272272, Lys239, posLast=231231, Lys223, Lys197, posLast=191191, Lys140, and Lys60
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BZW1 Gene

Domains & Families for BZW1 Gene

Gene Families for BZW1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BZW1 Gene

Suggested Antigen Peptide Sequences for BZW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BZW family.
  • Belongs to the BZW family.
genes like me logo Genes that share domains with BZW1: view

Function for BZW1 Gene

Molecular function for BZW1 Gene

UniProtKB/Swiss-Prot Function:
Enhances histone H4 gene transcription but does not seem to bind DNA directly.

Phenotypes From GWAS Catalog for BZW1 Gene

Gene Ontology (GO) - Molecular Function for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005488 binding IEA --
GO:0005515 protein binding IEA,IPI 17353931
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with BZW1: view
genes like me logo Genes that share phenotypes with BZW1: view

Animal Model Products

miRNA for BZW1 Gene

miRTarBase miRNAs that target BZW1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BZW1 Gene

Localization for BZW1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BZW1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10942595
GO:0016020 membrane IBA,HDA --
genes like me logo Genes that share ontologies with BZW1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BZW1 Gene

Pathways & Interactions for BZW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BZW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BZW1: view

No data available for Pathways by source and SIGNOR curated interactions for BZW1 Gene

Drugs & Compounds for BZW1 Gene

No Compound Related Data Available

Transcripts for BZW1 Gene

Unigene Clusters for BZW1 Gene

Basic leucine zipper and W2 domains 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BZW1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - -
SP6: -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10: - - -

Relevant External Links for BZW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BZW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BZW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BZW1 Gene

This gene is overexpressed in Bone (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BZW1 Gene

Protein tissue co-expression partners for BZW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BZW1 Gene:


SOURCE GeneReport for Unigene cluster for BZW1 Gene:


Evidence on tissue expression from TISSUES for BZW1 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Bone marrow(4.4)
  • Eye(4.4)
  • Lung(3.6)
  • Kidney(3.4)
  • Skin(3.3)
  • Pancreas(2.7)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with BZW1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BZW1 Gene

Orthologs for BZW1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BZW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BZW1 34 33
  • 99.33 (n)
(Monodelphis domestica)
Mammalia BZW1 34
  • 99 (a)
(Bos Taurus)
Mammalia BZW1 34 33
  • 96.18 (n)
(Canis familiaris)
Mammalia BZW1 34 33
  • 95.86 (n)
(Rattus norvegicus)
Mammalia Bzw1 33
  • 93.08 (n)
(Mus musculus)
Mammalia Bzw1 16 34 33
  • 92.6 (n)
(Ornithorhynchus anatinus)
Mammalia BZW1 34
  • 70 (a)
(Gallus gallus)
Aves BZW1 34 33
  • 86.49 (n)
(Anolis carolinensis)
Reptilia BZW1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bzw1 33
  • 84.49 (n)
MGC76227 33
African clawed frog
(Xenopus laevis)
Amphibia bzw1-prov 33
(Danio rerio)
Actinopterygii bzw1b 34
  • 79 (a)
bzw1a 34 33
  • 77.88 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2730 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002413 33
  • 56.82 (n)
fruit fly
(Drosophila melanogaster)
Insecta exba 34 33
  • 56.11 (n)
Species where no ortholog for BZW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BZW1 Gene

Gene Tree for BZW1 (if available)
Gene Tree for BZW1 (if available)
Evolutionary constrained regions (ECRs) for BZW1: view image

Paralogs for BZW1 Gene

Paralogs for BZW1 Gene

(2) SIMAP similar genes for BZW1 Gene using alignment to 7 proteins:

  • C9IZ80_HUMAN
  • C9J188_HUMAN
  • C9JV57_HUMAN
  • H0Y503_HUMAN Pseudogenes for BZW1 Gene

genes like me logo Genes that share paralogs with BZW1: view

Variants for BZW1 Gene

Sequence variations from dbSNP and Humsavar for BZW1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000137662 -- 200,817,763(+) T/C intron_variant
rs1000181290 -- 200,811,719(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000418010 -- 200,821,538(+) T/C intron_variant
rs1000549560 -- 200,810,516(+) A/G upstream_transcript_variant
rs1000609594 -- 200,819,103(+) A/G intron_variant

Variation tolerance for BZW1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BZW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BZW1 Gene

Disorders for BZW1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BZW1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phlebotomus fever
  • pappataci fever
- elite association - COSMIC cancer census association via MalaCards
Search BZW1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BZW1

genes like me logo Genes that share disorders with BZW1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BZW1 Gene

Publications for BZW1 Gene

  1. Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. (PMID: 11524015) Mitra P … van Wijnen AJ (Biochemistry 2001) 2 3 4 22 58
  2. BZW1, a novel proliferation regulator that promotes growth of salivary muocepodermoid carcinoma. (PMID: 19446954) Li S … Situ Z (Cancer letters 2009) 3 22 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for BZW1 Gene

Sources for BZW1 Gene

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