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Aliases for BUB1B-PAK6 Gene

Aliases for BUB1B-PAK6 Gene

  • BUB1B-PAK6 Readthrough 2 3 5

External Ids for BUB1B-PAK6 Gene

Summaries for BUB1B-PAK6 Gene

Entrez Gene Summary for BUB1B-PAK6 Gene

  • This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for BUB1B-PAK6 Gene

BUB1B-PAK6 (BUB1B-PAK6 Readthrough) is a Protein Coding gene. Among its related pathways are Developmental Biology and ErbB signaling pathway. An important paralog of this gene is PAK6.

Additional gene information for BUB1B-PAK6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BUB1B-PAK6 Gene

Genomics for BUB1B-PAK6 Gene

GeneHancer (GH) Regulatory Elements for BUB1B-PAK6 Gene

Promoters and enhancers for BUB1B-PAK6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I040218 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 -0.1 -61 0.2 CTCF PKNOX1 RB1 TEAD4 ZNF384 ZNF2 RAD21 RFX5 CC2D1A ARID2 BUB1B-PAK6 PAK6 BUB1B
GH15I040217 Enhancer 0.7 ENCODE 550.8 +0.1 57 0 CTCF ZNF654 ZNF362 RB1 TEAD1 TEAD4 TRIM22 ZNF384 REST ELF1 BUB1B-PAK6 PAK6 ENSG00000273786 BUB1B
GH15I040238 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.3 +22.6 22557 3.3 ATF1 RB1 BMI1 RCOR1 FOS ATF7 RUNX3 SMARCC1 CEBPB REST PAK6 SRP14-AS1 ENSG00000279537 ENSG00000260648 BUB1B-PAK6
GH15I040251 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.3 +35.1 35070 2.2 USF1 POLR2A BACH1 ZFX EZH2 EGR2 C15orf56 PAK6 ENSG00000279537 BUB1B-PAK6
GH15I040233 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +17.5 17453 1.8 USF1 MAX BACH1 EBF1 CTBP1 ZNF316 NFE2 MAFK RUNX3 USF2 ENSG00000260648 ENSG00000279537 PAK6 BUB1B-PAK6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BUB1B-PAK6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BUB1B-PAK6 Gene

Genomic Locations for BUB1B-PAK6 Gene
chr15:40,217,428-40,276,396
(GRCh38/hg38)
Size:
58,969 bases
Orientation:
Plus strand
chr15:40,509,629-40,568,597
(GRCh37/hg19)

Genomic View for BUB1B-PAK6 Gene

Genes around BUB1B-PAK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BUB1B-PAK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BUB1B-PAK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BUB1B-PAK6 Gene

Proteins for BUB1B-PAK6 Gene

  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RQB7
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    A0A0U1RQB7

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    133 amino acids
    Molecular mass:
    14939 Da
    Quaternary structure:
    No Data Available
  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BSN5
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    H3BSN5

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    160 amino acids
    Molecular mass:
    17672 Da
    Quaternary structure:
    No Data Available
  • Protein details for BUB1B-PAK6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H3BTB9
    Recommended name:
    BUB1B-PAK6 readthrough
    Protein Accession:
    H3BTB9

    Protein attributes for BUB1B-PAK6 Gene

    Size:
    141 amino acids
    Molecular mass:
    15993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BUB1B-PAK6 Gene

Post-translational modifications for BUB1B-PAK6 Gene

No Post-translational modifications

Other Protein References for BUB1B-PAK6 Gene

No data available for DME Specific Peptides for BUB1B-PAK6 Gene

Domains & Families for BUB1B-PAK6 Gene

Gene Families for BUB1B-PAK6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BUB1B-PAK6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BUB1B-PAK6: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for BUB1B-PAK6 Gene

Function for BUB1B-PAK6 Gene

Phenotypes From GWAS Catalog for BUB1B-PAK6 Gene

Gene Ontology (GO) - Molecular Function for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view
genes like me logo Genes that share phenotypes with BUB1B-PAK6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BUB1B-PAK6 Gene

Localization for BUB1B-PAK6 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for BUB1B-PAK6 Gene

Pathways & Interactions for BUB1B-PAK6 Gene

genes like me logo Genes that share pathways with BUB1B-PAK6: view

Interacting Proteins for BUB1B-PAK6 Gene

Gene Ontology (GO) - Biological Process for BUB1B-PAK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007094 mitotic spindle assembly checkpoint IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with BUB1B-PAK6: view

No data available for SIGNOR curated interactions for BUB1B-PAK6 Gene

Drugs & Compounds for BUB1B-PAK6 Gene

No Compound Related Data Available

Transcripts for BUB1B-PAK6 Gene

mRNA/cDNA for BUB1B-PAK6 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BUB1B-PAK6 Gene

No ASD Table

Relevant External Links for BUB1B-PAK6 Gene

GeneLoc Exon Structure for
BUB1B-PAK6
ECgene alternative splicing isoforms for
BUB1B-PAK6

Expression for BUB1B-PAK6 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BUB1B-PAK6 Gene

Orthologs for BUB1B-PAK6 Gene

Evolution for BUB1B-PAK6 Gene

ENSEMBL:
Gene Tree for BUB1B-PAK6 (if available)
TreeFam:
Gene Tree for BUB1B-PAK6 (if available)

No data available for Orthologs for BUB1B-PAK6 Gene

Paralogs for BUB1B-PAK6 Gene

Paralogs for BUB1B-PAK6 Gene

genes like me logo Genes that share paralogs with BUB1B-PAK6: view

Variants for BUB1B-PAK6 Gene

Sequence variations from dbSNP and Humsavar for BUB1B-PAK6 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1060499945 uncertain-significance, Mosaic variegated aneuploidy syndrome 1 40,220,585(+) G/T intron_variant
rs139066741 likely-benign, Mosaic variegated aneuploidy syndrome 40,217,601(+) C/A/T 5_prime_UTR_variant
rs143232848 uncertain-significance, Mosaic variegated aneuploidy syndrome 1 40,217,602(+) G/A 5_prime_UTR_variant
rs1802286 benign, Mosaic variegated aneuploidy syndrome, not specified 40,218,461(+) C/T intron_variant
rs28989183 pathogenic, affects, uncertain-significance, Mosaic variegated aneuploidy syndrome 1, Premature chromatid separation trait, Mosaic variegated aneuploidy syndrome 40,217,580(+) G/C 5_prime_UTR_variant

Additional Variant Information for BUB1B-PAK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BUB1B-PAK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for BUB1B-PAK6 Gene

Disorders for BUB1B-PAK6 Gene

Additional Disease Information for BUB1B-PAK6

No disorders were found for BUB1B-PAK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BUB1B-PAK6 Gene

Publications for BUB1B-PAK6 Gene

  1. p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). (PMID: 23132866) Liu T … Li F (The Journal of biological chemistry 2013) 3 58
  2. Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. (PMID: 22339630) Shepelev MV … Korobko IV (Biochemistry. Biokhimiia 2012) 3 58
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58
  4. The emerging importance of group II PAKs. (PMID: 20070256) Wells CM … Jones GE (The Biochemical journal 2010) 3 58
  5. Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion. (PMID: 20817787) McCarty SK … Ringel MD (Endocrine-related cancer 2010) 3 58

Products for BUB1B-PAK6 Gene

Sources for BUB1B-PAK6 Gene

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