Aliases for BTNL9 Gene

Aliases for BTNL9 Gene

  • Butyrophilin Like 9 2 3 5
  • Butyrophilin-Like Protein 9 3 4
  • BTN8 2 3
  • Butyrophilin-Like 9 2
  • Butyrophilin 3 3
  • VDLS1900 3
  • FLJ32535 2
  • BTNL9 5
  • BTN3 3

External Ids for BTNL9 Gene

Previous GeneCards Identifiers for BTNL9 Gene

  • GC05P180577
  • GC05P180399
  • GC05P180467
  • GC05P175192
  • GC05P181040

Summaries for BTNL9 Gene

GeneCards Summary for BTNL9 Gene

BTNL9 (Butyrophilin Like 9) is a Protein Coding gene. Among its related pathways are Butyrophilin (BTN) family interactions and Innate Immune System. An important paralog of this gene is BTN3A3.

Additional gene information for BTNL9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTNL9 Gene

Genomics for BTNL9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BTNL9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J181040 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 600.7 +2.0 2029 5 CTCF PHF21A ZSCAN4 REST RAD21 SP1 SCRT2 EGR1 ESRRA SMC3 BTNL9 MIR8089 BTNL3 OR2V1
GH05J181046 Enhancer 0.8 FANTOM5 20.1 +6.6 6573 0.4 ARHGAP35 IKZF1 DDX20 PHF21A MTA1 PATZ1 ZNF239 GATAD2A NFRKB ZNF266 lnc-OR2V1-1 TRIM52 ENSG00000233937 ZFP62 CNOT6 BTNL9 SNORD96A RACK1 MGAT1 BTNL8
GH05J180350 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.4 -687.2 -687234 3.5 RFX1 KDM1A PKNOX1 POLR2A PATZ1 EZH2 GTF2F1 ZNF600 RFX3 KLF9 GFPT2 OR2Y1 BTNL9 RF00017-5180 piR-55032 MAPK9
GH05J181121 Enhancer 0.5 Ensembl 10.9 +82.4 82426 0.6 IKZF1 PKNOX1 REST CTBP1 CTCF SPI1 RAD21 MEIS2 CREB1 ENSG00000248560 OR2V2 BTNL9 BTNL8 OR2V1
GH05J181120 Enhancer 0.3 Ensembl 10.9 +80.7 80728 1.2 FOSL2 JUND ENSG00000248560 OR2V2 BTNL9 BTNL8 OR2V1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTNL9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BTNL9

Genomic Locations for BTNL9 Gene

Genomic Locations for BTNL9 Gene
21,654 bases
Plus strand
21,299 bases
Plus strand

Genomic View for BTNL9 Gene

Genes around BTNL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL9 Gene

Proteins for BTNL9 Gene

  • Protein details for BTNL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A6NL42
    • Q6P660
    • Q96DM5

    Protein attributes for BTNL9 Gene

    535 amino acids
    Molecular mass:
    59716 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL9 Gene


neXtProt entry for BTNL9 Gene

Post-translational modifications for BTNL9 Gene

  • Glycosylation at Asn102, Asn139, and Asn224
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTNL9 Gene

Domains & Families for BTNL9 Gene

Gene Families for BTNL9 Gene

Protein Domains for BTNL9 Gene

  • Butyrophylin C-terminal DUF signature
  • SPRY-associated domain

Suggested Antigen Peptide Sequences for BTNL9 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52190, highly similar to Butyrophilin-like protein 9 (B7Z4Y8_HUMAN)
  • Butyrophilin-like protein 9 (BTNL9_HUMAN)
  • BTNL9 protein (Q8N324_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL9: view

Function for BTNL9 Gene

Phenotypes From GWAS Catalog for BTNL9 Gene

Gene Ontology (GO) - Molecular Function for BTNL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with BTNL9: view
genes like me logo Genes that share phenotypes with BTNL9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BTNL9

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTNL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTNL9 Gene

Localization for BTNL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL9 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTNL9 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTNL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL9: view

Pathways & Interactions for BTNL9 Gene

genes like me logo Genes that share pathways with BTNL9: view

Pathways by source for BTNL9 Gene

Gene Ontology (GO) - Biological Process for BTNL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA 21873635
GO:0050776 regulation of immune response IBA 21873635
GO:0050852 T cell receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with BTNL9: view

No data available for SIGNOR curated interactions for BTNL9 Gene

Drugs & Compounds for BTNL9 Gene

No Compound Related Data Available

Transcripts for BTNL9 Gene

mRNA/cDNA for BTNL9 Gene

10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTNL9

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL9 Gene

No ASD Table

Relevant External Links for BTNL9 Gene

GeneLoc Exon Structure for

Expression for BTNL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTNL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL9 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.2), Breast - Mammary Tissue (x6.7), Adipose - Subcutaneous (x6.6), and Lung (x4.0).

Protein differential expression in normal tissues from HIPED for BTNL9 Gene

This gene is overexpressed in Lung (42.5), Placenta (16.8), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL9 Gene

Protein tissue co-expression partners for BTNL9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BTNL9

SOURCE GeneReport for Unigene cluster for BTNL9 Gene:


Evidence on tissue expression from TISSUES for BTNL9 Gene

  • Intestine(4.3)
  • Nervous system(4.1)
  • Spleen(2.4)
genes like me logo Genes that share expression patterns with BTNL9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTNL9 Gene

Orthologs for BTNL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL9 30 31
  • 97.94 (n)
(Bos Taurus)
Mammalia BTNL9 30 31
  • 78.43 (n)
(Canis familiaris)
Mammalia BTNL9 30 31
  • 77.98 (n)
(Mus musculus)
Mammalia Btnl9 30 17 31
  • 75.64 (n)
(Rattus norvegicus)
Mammalia LOC684480 30
  • 73.75 (n)
(Monodelphis domestica)
Mammalia BTNL9 31
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 39 (a)
Species where no ortholog for BTNL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for BTNL9 Gene

Gene Tree for BTNL9 (if available)
Gene Tree for BTNL9 (if available)
Evolutionary constrained regions (ECRs) for BTNL9: view image

Paralogs for BTNL9 Gene

(31) SIMAP similar genes for BTNL9 Gene using alignment to 4 proteins:

  • A6NJ33_HUMAN
  • B7Z4Y8_HUMAN
  • Q8N324_HUMAN
genes like me logo Genes that share paralogs with BTNL9: view

Variants for BTNL9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BTNL9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
716754 Benign: not provided 181,053,326(+) C/T INTRON_VARIANT
719432 Benign: not provided 181,048,195(+) T/C SYNONYMOUS_VARIANT
719433 Benign: not provided 181,059,811(+) C/T SYNONYMOUS_VARIANT
731597 Benign: not provided 181,059,730(+) C/T SYNONYMOUS_VARIANT
785156 Benign: not provided 181,058,374(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for BTNL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for BTNL9 Gene

Variant ID Type Subtype PubMed ID
dgv10250n54 CNV gain 21841781
dgv10251n54 CNV gain 21841781
dgv5855n100 CNV gain 25217958
dgv5856n100 CNV gain 25217958
dgv5857n100 CNV gain 25217958
dgv5858n100 CNV gain 25217958
dgv5859n100 CNV gain 25217958
dgv5860n100 CNV gain 25217958
dgv735n27 CNV gain 19166990
esv1001577 CNV insertion 20482838
esv1265655 CNV insertion 17803354
esv1267126 CNV insertion 17803354
esv2759400 CNV gain 17122850
esv2763931 CNV gain+loss 21179565
esv3335910 CNV duplication 20981092
esv3447138 CNV insertion 20981092
esv3607801 CNV gain 21293372
esv3607803 CNV loss 21293372
esv3607804 CNV loss 21293372
esv3607805 CNV gain 21293372
esv3890777 CNV gain 25118596
esv3890778 CNV gain 25118596
nsv1015341 CNV gain 25217958
nsv1021633 CNV gain 25217958
nsv10792 CNV gain 18304495
nsv1125865 CNV tandem duplication 24896259
nsv1161326 CNV duplication 26073780
nsv428133 CNV gain 18775914
nsv462588 CNV gain 19166990
nsv471062 CNV gain 18288195
nsv509112 CNV insertion 20534489
nsv5162 CNV insertion 18451855
nsv818395 CNV gain 17921354
nsv950743 CNV deletion 24416366

Variation tolerance for BTNL9 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTNL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL9 Gene

Disorders for BTNL9 Gene

No disorders were found for BTNL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL9 Gene

Publications for BTNL9 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Butyrophilin-Like 9 (BTNL9) Suppresses Invasion and Correlates with Favorable Prognosis of Uveal Melanoma. (PMID: 31039142) Jiang Z … Liu F (Medical science monitor : international medical journal of experimental and clinical research 2019) 3

Products for BTNL9 Gene

Sources for BTNL9 Gene