Aliases for BTNL8 Gene

Aliases for BTNL8 Gene

  • Butyrophilin Like 8 2 3 5
  • Butyrophilin-Like Protein 8 3 4
  • B7-H5 Costimulatory Molecule 3
  • Butyrophilin-Like 8 2
  • BTN9.2 3

External Ids for BTNL8 Gene

Previous GeneCards Identifiers for BTNL8 Gene

  • GC05P180436
  • GC05P180258
  • GC05P180326
  • GC05P175051
  • GC05P180907
  • GC05P181083
  • GC05P181111
  • GC05P180908
  • GC05P180940
  • GC05P180971
  • GC05P181002
  • GC05P181009
  • GC05P181037
  • GC05P181062

Summaries for BTNL8 Gene

GeneCards Summary for BTNL8 Gene

BTNL8 (Butyrophilin Like 8) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Butyrophilin (BTN) family interactions. An important paralog of this gene is BTNL3.

UniProtKB/Swiss-Prot Summary for BTNL8 Gene

  • May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.

Additional gene information for BTNL8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTNL8 Gene

Genomics for BTNL8 Gene

GeneHancer (GH) Regulatory Elements for BTNL8 Gene

Promoters and enhancers for BTNL8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J180897 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 750.6 -0.1 -62 3.1 GATA3 BTNL8 BTNL3 piR-61240-239
GH05J180909 Promoter 0.3 EPDnew 750.4 +10.5 10477 0.1 ENSG00000222852 BTNL8 piR-45726-037
GH05J180869 Enhancer 1 Ensembl ENCODE 10.4 -29.9 -29895 0.5 CTCF CC2D1A L3MBTL2 RAD21 ZNF280D ZC3H8 PRDM1 CDC5L IKZF1 ARID2 lnc-BTNL8-1 ZFP62 ENSG00000233937 MGAT1 BTNL8 TRIM7 ENSG00000250900
GH05J181037 Enhancer 0.6 Ensembl 16.8 +138.6 138635 0.6 ZIC2 PKNOX1 SP2 ZBTB20 ZBTB48 MTA3 ZBTB17 ZFHX2 GLIS1 SP1 BTNL8 BTNL9 RF00026-914 RNU6-1036P
GH05J180873 Enhancer 1.3 FANTOM5 Ensembl ENCODE 4.9 -25.2 -25176 2.6 SMARCE1 CC2D1A L3MBTL2 DACH1 TEAD4 ZC3H8 MAFK BACH1 SMARCA4 ZNF639 ENSG00000233937 ZFP62 LINC00847 BTNL3 BTNL8 MGAT1 lnc-BTNL8-1 piR-61240-239
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTNL8 on UCSC Golden Path with GeneCards custom track

Genomic Locations for BTNL8 Gene

Genomic Locations for BTNL8 Gene
53,090 bases
Plus strand
51,830 bases
Plus strand

Genomic View for BTNL8 Gene

Genes around BTNL8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTNL8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTNL8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTNL8 Gene

Proteins for BTNL8 Gene

  • Protein details for BTNL8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 8
    Protein Accession:
    Secondary Accessions:
    • A4QMZ8
    • A6NEX6
    • B7Z409
    • B7Z5B1
    • E9PEF6
    • E9PG07
    • F2Z2B2
    • F8W712
    • Q9H730

    Protein attributes for BTNL8 Gene

    500 amino acids
    Molecular mass:
    56748 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL8 Gene

neXtProt entry for BTNL8 Gene

Post-translational modifications for BTNL8 Gene

  • Glycosylation at Asn103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTNL8 Gene

Domains & Families for BTNL8 Gene

Gene Families for BTNL8 Gene

Suggested Antigen Peptide Sequences for BTNL8 Gene

GenScript: Design optimal peptide antigens:
  • BTNL8 protein (A4QMZ8_HUMAN)
  • Butyrophilin-like protein 8 (BTNL8_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL8: view

Function for BTNL8 Gene

Molecular function for BTNL8 Gene

UniProtKB/Swiss-Prot Function:
May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production.
UniProtKB/Swiss-Prot Induction:
Down-regulated in neutrophils after treatment with LPS and TNF.

Phenotypes From GWAS Catalog for BTNL8 Gene

Gene Ontology (GO) - Molecular Function for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with BTNL8: view
genes like me logo Genes that share phenotypes with BTNL8: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTNL8 Gene

Localization for BTNL8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTNL8 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
endoplasmic reticulum 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTNL8 Gene

Pathways & Interactions for BTNL8 Gene

genes like me logo Genes that share pathways with BTNL8: view

Pathways by source for BTNL8 Gene

Gene Ontology (GO) - Biological Process for BTNL8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response IBA 21873635
GO:0050852 T cell receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with BTNL8: view

No data available for SIGNOR curated interactions for BTNL8 Gene

Drugs & Compounds for BTNL8 Gene

No Compound Related Data Available

Transcripts for BTNL8 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL8 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP2: -

Relevant External Links for BTNL8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTNL8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTNL8 Gene

This gene is overexpressed in Whole Blood (x17.9), Small Intestine - Terminal Ileum (x14.5), and Colon - Transverse (x10.5).

Protein differential expression in normal tissues from HIPED for BTNL8 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTNL8 Gene

Protein tissue co-expression partners for BTNL8 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTNL8 Gene:


SOURCE GeneReport for Unigene cluster for BTNL8 Gene:


mRNA Expression by UniProt/SwissProt for BTNL8 Gene:

Tissue specificity: Expressed in neutrophils. Isoforms 1 and 5 are expressed at high levels in the colon, lung,testis, lymph nodes and thyroid tissue. Isoform 5, but not isoform 1, is detected in spleen.

Evidence on tissue expression from TISSUES for BTNL8 Gene

  • Intestine(4.4)
genes like me logo Genes that share expression patterns with BTNL8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BTNL8 Gene

Orthologs for BTNL8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTNL8 33 32
  • 98.76 (n)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 44 (a)
-- 33
  • 37 (a)
(Monodelphis domestica)
Mammalia -- 33
  • 40 (a)
-- 33
  • 39 (a)
Species where no ortholog for BTNL8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL8 Gene

Gene Tree for BTNL8 (if available)
Gene Tree for BTNL8 (if available)
Evolutionary constrained regions (ECRs) for BTNL8: view image

Paralogs for BTNL8 Gene

(13) SIMAP similar genes for BTNL8 Gene using alignment to 3 proteins:

  • D6R9I8_HUMAN
genes like me logo Genes that share paralogs with BTNL8: view

Variants for BTNL8 Gene

Sequence variations from dbSNP and Humsavar for BTNL8 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000087075 -- 180,908,570(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000164800 -- 180,907,313(+) A/C/G genic_upstream_transcript_variant, intron_variant
rs1000203615 -- 180,928,264(+) C/T intron_variant
rs1000255270 -- 180,900,929(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000295706 -- 180,940,842(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTNL8 Gene

Variant ID Type Subtype PubMed ID
dgv10246n54 CNV loss 21841781
dgv1066e199 CNV deletion 23128226
dgv1685e212 CNV gain 25503493
dgv1686e212 CNV loss 25503493
dgv1687e212 CNV loss 25503493
dgv1688e212 CNV gain 25503493
dgv1689e212 CNV gain 25503493
dgv1690e212 CNV gain 25503493
dgv215n111 OTHER complex 26073780
dgv5851n100 CNV gain 25217958
dgv5852n100 CNV gain+loss 25217958
dgv5853n100 CNV gain+loss 25217958
dgv5854n100 CNV loss 25217958
dgv5855n100 CNV gain 25217958
dgv9n29 CNV loss 16826518
esv2421695 CNV deletion 20811451
esv2427567 CNV insertion 19546169
esv25559 CNV gain+loss 19812545
esv2601471 CNV insertion 19546169
esv2760983 CNV loss 21179565
esv29779 CNV gain+loss 19812545
esv3441053 CNV insertion 20981092
esv3607798 CNV loss 21293372
esv3607799 CNV gain 21293372
esv992764 CNV loss 20482838
nsv1074358 CNV deletion 25765185
nsv10790 CNV gain+loss 18304495
nsv10791 CNV gain+loss 18304495
nsv1137540 CNV deletion 24896259
nsv1161322 CNV duplication 26073780
nsv1161325 CNV deletion 26073780
nsv428133 CNV gain 18775914
nsv513283 CNV loss 21212237
nsv514338 CNV gain+loss 21397061
nsv600682 CNV loss 21841781
nsv600683 CNV gain 21841781
nsv600684 CNV loss 21841781
nsv600685 CNV gain+loss 21841781
nsv600687 CNV loss 21841781
nsv819450 CNV loss 19587683
nsv820020 CNV loss 19587683
nsv821169 CNV deletion 20802225
nsv823367 CNV loss 20364138
nsv830566 CNV loss 17160897
nsv950741 CNV duplication 24416366
nsv950742 CNV deletion 24416366

Variation tolerance for BTNL8 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTNL8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL8 Gene

Disorders for BTNL8 Gene

Additional Disease Information for BTNL8

No disorders were found for BTNL8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTNL8 Gene

Publications for BTNL8 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 56
  2. BTNL8, a butyrophilin-like molecule that costimulates the primary immune response. (PMID: 24036152) Chapoval AI … Mezes PS (Molecular immunology 2013) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for BTNL8 Gene

Sources for BTNL8 Gene