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This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this ... See more...
Aliases for BTN3A2 Gene
Aliases for BTN3A2 Gene
External Ids for BTN3A2 Gene
- HGNC: 1139
- Entrez Gene: 11118
- Ensembl: ENSG00000186470
- OMIM: 613594
- UniProtKB: P78410
Previous GeneCards Identifiers for BTN3A2 Gene
- GC06P026423
- GC06P026473
- GC06P026308
Summaries for BTN3A2 Gene
-
This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
GeneCards Summary for BTN3A2 Gene
BTN3A2 (Butyrophilin Subfamily 3 Member A2) is a Protein Coding gene. Among its related pathways are Butyrophilin (BTN) family interactions and Innate Immune System. An important paralog of this gene is BTN3A3.
UniProtKB/Swiss-Prot Summary for BTN3A2 Gene
-
Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
Additional gene information for BTN3A2 Gene
- HGNC(1139)
- Entrez Gene(11118)
- Ensembl(ENSG00000186470)
- OMIM(613594)
- UniProtKB(P78410)
- Open Targets Platform(ENSG00000186470)
- Monarch Initiative
- Search for BTN3A2 at DataMed
- Search for BTN3A2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTN3A2 Gene
Genomics for BTN3A2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BTN3A2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BTN3A2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BTN3A2
- Top Transcription factor binding sites by QIAGEN in the BTN3A2 gene promoter:
-
- POU2F1
- POU2F1a
Genomic Locations for BTN3A2 Gene
Genomic Locations for BTN3A2 Gene
- chr6:26,365,159-26,378,320
- (GRCh38/hg38)
- Size:
- 13,162 bases
- Orientation:
- Plus strand
- chr6:26,365,387-26,378,548
- (GRCh37/hg19)
- Size:
- 13,162 bases
- Orientation:
- Plus strand
Genomic View for BTN3A2 Gene
Genes around BTN3A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by HGNC
- 6p22.2 by Entrez Gene
- 6p22.2 by Ensembl
BTN3A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BTN3A2 Gene
Proteins for BTN3A2 Gene
-
Protein details for BTN3A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78410-BT3A2_HUMAN
- Recommended name:
- Butyrophilin subfamily 3 member A2
- Protein Accession:
- P78410
- B4DRT7
- B4E103
- F5H791
- F8W6E0
- O00477
- O15338
- O75658
- Q76PA0
- Q9BU81
- Q9NR44
Protein attributes for BTN3A2 Gene
- Size:
- 334 amino acids
- Molecular mass:
- 36428 Da
- Quaternary structure:
-
- Homodimer.
- SequenceCaution:
-
- Sequence=AAB53424.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC02652.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAC02655.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for BTN3A2 Gene
Post-translational modifications for BTN3A2 Gene
Other Protein References for BTN3A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005248884.1
- XP_005248888.1
- XP_005248889.1
- XP_006715042.1
- XP_006715043.1
- XP_006715044.1
- XP_006715045.1
- XP_011512569.1
- XP_011512571.1
- XP_011512572.1
- XP_011512573.1
- XP_016865700.1
- XP_016865701.1
- XP_016865702.1
- XP_016865703.1
- XP_016865704.1
- XP_016865705.1
- XP_016865706.1
- NP_001184175.1
- NP_001184176.1
- NP_001184177.1
- NP_001184178.1
- NP_008978.2
Antibody Products
- LifeSpan BioSciences BTN3A2 Monoclonal Antibody
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-
Abcam antibodies for BTN3A2
- Invitrogen Antibodies for BTN3A2 (AFLGC-BTN3A2)
Protein Products
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- Sino Biological Recombinant Proteins for BTN3A2
- antibodies-online: Show 9 available BTN3A2 Proteins ranked by validation data
- Compare Top BTN3A2 Proteins
-
Quality Products:
-
ProSci Proteins for BTN3A2
-
Abcam proteins for BTN3A2
No data available for DME Specific Peptides for BTN3A2 Gene
Domains & Families for BTN3A2 Gene
Gene Families for BTN3A2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BTN3A2 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for BTN3A2 Gene
- GenScript: Design optimal peptide antigens:
-
- Butyrophilin subfamily 3 member A2 (BT3A2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P78410- Family:
-
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
Function for BTN3A2 Gene
Molecular function for BTN3A2 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
- GENATLAS Biochemistry:
- butyrophilin subfamily 3,member A2,B box family of proteins,involved in cell proliferation and development
Phenotypes From GWAS Catalog for BTN3A2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IBA | 21873635 |
Phenotypes for BTN3A2 Gene
Animal Model Products
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CRISPR Products
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miRNA for BTN3A2 Gene
- miRTarBase miRNAs that target BTN3A2
-
- hsa-miR-615-3p (MIRT039803)
- hsa-miR-17-5p (MIRT168215)
- hsa-miR-20a-5p (MIRT168216)
- hsa-miR-93-5p (MIRT168217)
- hsa-miR-106b-5p (MIRT168223)
- hsa-miR-20b-5p (MIRT168233)
- hsa-miR-519d-3p (MIRT168245)
- hsa-miR-5698 (MIRT607648)
- hsa-miR-7641 (MIRT607649)
- hsa-miR-4713-5p (MIRT607650)
- hsa-miR-143-5p (MIRT607651)
- hsa-miR-4430 (MIRT607652)
- hsa-miR-3652 (MIRT607653)
- hsa-miR-4284 (MIRT607654)
- hsa-miR-122-5p (MIRT607655)
- hsa-miR-504-3p (MIRT607656)
- hsa-miR-3135b (MIRT607657)
- hsa-miR-3194-3p (MIRT607658)
- hsa-miR-6499-3p (MIRT607659)
- hsa-miR-4695-3p (MIRT607660)
- hsa-miR-2276-3p (MIRT607661)
- hsa-miR-4638-5p (MIRT607662)
- hsa-miR-1307-3p (MIRT607663)
- hsa-miR-2116-3p (MIRT607664)
- hsa-miR-532-3p (MIRT607665)
- hsa-miR-150-5p (MIRT607666)
- hsa-miR-1304-3p (MIRT607667)
- hsa-miR-6741-3p (MIRT607668)
- hsa-miR-4726-3p (MIRT607669)
- hsa-miR-6764-5p (MIRT607670)
- hsa-miR-1915-3p (MIRT607671)
- hsa-miR-6840-3p (MIRT607672)
- hsa-miR-5693 (MIRT607673)
- hsa-miR-6890-3p (MIRT607674)
- hsa-miR-6796-3p (MIRT607675)
- hsa-miR-6881-3p (MIRT716893)
- hsa-miR-130b-5p (MIRT716895)
- hsa-miR-877-3p (MIRT716896)
- hsa-miR-153-5p (MIRT716897)
- hsa-miR-4661-3p (MIRT716898)
- hsa-miR-629-3p (MIRT721473)
- hsa-miR-519e-5p (MIRT721474)
- hsa-miR-515-5p (MIRT721475)
- hsa-miR-6720-5p (MIRT721476)
- hsa-miR-6512-3p (MIRT721477)
- hsa-miR-3160-5p (MIRT721478)
- hsa-miR-766-3p (MIRT721479)
- hsa-miR-6849-3p (MIRT721480)
- hsa-miR-6865-3p (MIRT721481)
- hsa-miR-3614-3p (MIRT721482)
miRNA Products
Inhibitory RNA Products
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Clone Products
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- Sino Biological Human cDNA Clone for BTN3A2
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Cell Line Products
-
Horizon Cell Lines for BTN3A2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN3A2 Gene
Localization for BTN3A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BTN3A2 Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTN3A2 Gene
Pathways & Interactions for BTN3A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Butyrophilin (BTN) family interactions | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for BTN3A2 Gene
3 Reactome pathways for BTN3A2 Gene
Interacting Proteins for BTN3A2 Gene
Selected Interacting proteins:
P78410-BT3A2_HUMAN
ENSP00000348751
for BTN3A2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for BTN3A2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001817 | regulation of cytokine production | IBA | 21873635 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002456 | T cell mediated immunity | IMP | 22767497 |
| GO:0050776 | regulation of immune response | IBA | 21873635 |
No data available for SIGNOR curated interactions for BTN3A2 Gene
Transcripts for BTN3A2 Gene
mRNA/cDNA for BTN3A2 Gene
- 5 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000532865 885 nts (view in UCSC)
- ENST00000530653 496 nts (view in UCSC)
- ENST00000527417 593 nts (view in UCSC)
- ENST00000524682 644 nts (view in UCSC)
- ENST00000528222 885 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BTN3A2 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||
| SP2: | - | ||||||||||||||
| SP3: |
Relevant External Links for BTN3A2 Gene
- GeneLoc Exon Structure for
- BTN3A2
Expression for BTN3A2 Gene
mRNA differential expression in normal tissues according to GTEx for BTN3A2 Gene
This gene is overexpressed in Whole Blood (x5.4) and Spleen (x4.4).
This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Ovary (26.2), and CD8 Tcells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN3A2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BTN3A2
SOURCE GeneReport for Unigene cluster for BTN3A2 Gene:
Hs.376046mRNA Expression by UniProt/SwissProt for BTN3A2 Gene:
P78410-BT3A2_HUMAN
Tissue specificity:
Detected in T-cells and natural killer cells.
Evidence on tissue expression from TISSUES for BTN3A2 Gene
- Skin(4.6)
- Nervous system(2.7)
- Spleen(2.7)
- Lymph node(2.6)
- Blood(2.5)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for BTN3A2
-
OriGene qPCR primer pairs and template standards for BTN3A2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTN3A2 Gene
Orthologs for BTN3A2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BTN3A2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Btnl10 31 |
|
ManyToMany | |
| Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany |
- Species where no ortholog for BTN3A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for BTN3A2 Gene
- ENSEMBL:
- Gene Tree for BTN3A2 (if available)
- TreeFam:
- Gene Tree for BTN3A2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BTN3A2: view image
Paralogs for BTN3A2 Gene
Paralogs for BTN3A2 Gene
(14) SIMAP similar genes for BTN3A2 Gene using alignment to 6 proteins:
- BT3A2_HUMAN
- E9PIU5_HUMAN
- E9PJE9_HUMAN
- E9PRR1_HUMAN
- E9PRX1_HUMAN
- S4R3N0_HUMAN
Variants for BTN3A2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BTN3A2 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 768070 | Benign: not provided | 26,374,343(+) | G/A | SYNONYMOUS_VARIANT | |
| 770547 | Benign: not provided | 26,368,710(+) | C/T | SYNONYMOUS_VARIANT | |
| rs12205731 | - | p.Ala182Thr | |||
| rs13216828 | - | p.Ser307Asn | |||
| rs35183513 | - | p.Arg211Lys |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2673332 | CNV | deletion | 23128226 |
| esv2731728 | CNV | deletion | 23290073 |
| esv2731730 | CNV | deletion | 23290073 |
| esv3608402 | CNV | loss | 21293372 |
| esv3608403 | CNV | loss | 21293372 |
| esv3608404 | CNV | gain | 21293372 |
| esv3608405 | CNV | loss | 21293372 |
| esv3890802 | CNV | loss | 25118596 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv1030863 | CNV | gain+loss | 25217958 |
| nsv527328 | CNV | loss | 19592680 |
| nsv970085 | CNV | duplication | 23825009 |
| nsv970086 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.70;
83.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BTN3A2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN3A2 Gene
Disorders for BTN3A2 Gene
Additional Disease Information for BTN3A2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for BTN3A2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN3A2 Gene
Publications for BTN3A2 Gene
- A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4
- Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R … Pontarotti P (Immunogenetics 1997) 3 4 23
- The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. (PMID: 22846996) Palakodeti A … Adams EJ (The Journal of biological chemistry 2012) 3 4
- Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. (PMID: 22767497) Harly C … Scotet E (Blood 2012) 3 4
- Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. (PMID: 21918970) Messal N … Olive D (European journal of immunology 2011) 3 4
ExternalLinks
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- Search Knockout (KO) Validated Antibodies
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- Browse Recombinant Antibodies
- Invitrogen Antibodies for BTN3A2 (AFLGC-BTN3A2)
- VectorBuilder Custom and pre-made DNA vectors for BTN3A2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for BTN3A2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for BTN3A2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BTN3A2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BTN3A2
- antibodies-online: Show 3 available BTN3A2 Antibodies ranked by validation data
- Compare Top BTN3A2 Antibodies
- antibodies-online: Search results for available BTN3A2 related products ranked by validation data
- antibodies-online: Show 9 available BTN3A2 Proteins ranked by validation data
- Compare Top BTN3A2 Proteins
- Quality Products:
- Search for BTN3A2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for BTN3A2
- Horizon Cell Lines for BTN3A2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BTN3A2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTN3A2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BTN3A2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTN3A2
Sources for BTN3A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB