Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTN3A2 Gene

Aliases for BTN3A2 Gene

  • Butyrophilin Subfamily 3 Member A2 2 3 3 5
  • BT3.2 3 4
  • BTF4 3 4
  • Butyrophilin, Subfamily 3, Member A2 2
  • Butyrophilin Protein 3
  • BTN3.2 3
  • CD277 3
  • BTF3 4

External Ids for BTN3A2 Gene

Previous GeneCards Identifiers for BTN3A2 Gene

  • GC06P026423
  • GC06P026473
  • GC06P026308

Summaries for BTN3A2 Gene

Entrez Gene Summary for BTN3A2 Gene

  • This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for BTN3A2 Gene

BTN3A2 (Butyrophilin Subfamily 3 Member A2) is a Protein Coding gene. Among its related pathways are Butyrophilin (BTN) family interactions and Innate Immune System. An important paralog of this gene is BTN3A3.

UniProtKB/Swiss-Prot for BTN3A2 Gene

  • Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

Additional gene information for BTN3A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN3A2 Gene

Genomics for BTN3A2 Gene

GeneHancer (GH) Regulatory Elements for BTN3A2 Gene

Promoters and enhancers for BTN3A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026363 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 718.5 +0.5 514 3.9 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 BTN3A2 BTN2A2 BTN2A1 GUSBP2 BTN2A3P ABT1 BTN3A1 HMGN4 ZNF322 BTN3A3
GH06J026420 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 56.6 +56.2 56175 2.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 BRCA1 ZNF48 YY1 POLR2B BTN2A3P BTN3A3 BTN3A2 BTN2A1 BTN3A1 BTN2A2 ABT1 HMGN4
GH06J026401 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 54.6 +37.1 37100 2.3 HDGF FOXA2 ATF1 SMAD1 ARNT ARID4B DMAP1 ZNF48 YY1 SLC30A9 BTN3A1 BTN3A2 BTN2A1 BTN2A2 BTN1A1 HMGN4 HIST1H4H HIST1H2APS4 HIST1H3G BTN2A3P
GH06J026439 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 47.9 +75.3 75304 2.5 HDGF ATF1 FOXA2 DMAP1 ZNF2 YY1 ZNF207 CAVIN1 NFYC NCOA1 BTN3A3 BTN3A2 BTN2A1 BTN3A1 ENSG00000271755 BTN2A2 BTN1A1 BTN2A3P ZNF204P
GH06J026549 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 52.7 +185.4 185369 1.3 MLX ZFP64 ARID4B SIN3A ZNF48 YY1 ZNF143 CAVIN1 SP5 NFYC BTN3A2 ABT1 HMGN4 BTN2A2 LOC102724851 GC06P027196 PIR59270 GC06P027240 GC06M026707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTN3A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTN3A2 gene promoter:
  • POU2F1
  • POU2F1a

Genomic Locations for BTN3A2 Gene

Genomic Locations for BTN3A2 Gene
86,495 bases
Plus strand
13,162 bases
Plus strand

Genomic View for BTN3A2 Gene

Genes around BTN3A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN3A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN3A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN3A2 Gene

Proteins for BTN3A2 Gene

  • Protein details for BTN3A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 3 member A2
    Protein Accession:
    Secondary Accessions:
    • B4DRT7
    • B4E103
    • F5H791
    • F8W6E0
    • O00477
    • O15338
    • O75658
    • Q76PA0
    • Q9BU81
    • Q9NR44

    Protein attributes for BTN3A2 Gene

    334 amino acids
    Molecular mass:
    36428 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAB53424.1; Type=Frameshift; Positions=317; Evidence={ECO:0000305}; Sequence=AAC02652.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305}; Sequence=AAC02655.1; Type=Frameshift; Positions=334; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BTN3A2 Gene

    Alternative splice isoforms for BTN3A2 Gene


neXtProt entry for BTN3A2 Gene

Post-translational modifications for BTN3A2 Gene

Antibody Products

  • Abcam antibodies for BTN3A2
  • Boster Bio Antibodies for BTN3A2

No data available for DME Specific Peptides for BTN3A2 Gene

Domains & Families for BTN3A2 Gene

Gene Families for BTN3A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for BTN3A2 Gene

Suggested Antigen Peptide Sequences for BTN3A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN3A2: view

Function for BTN3A2 Gene

Molecular function for BTN3A2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.
GENATLAS Biochemistry:
butyrophilin subfamily 3,member A2,B box family of proteins,involved in cell proliferation and development

Phenotypes From GWAS Catalog for BTN3A2 Gene

Gene Ontology (GO) - Molecular Function for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
genes like me logo Genes that share ontologies with BTN3A2: view
genes like me logo Genes that share phenotypes with BTN3A2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN3A2 Gene

Localization for BTN3A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN3A2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTN3A2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN3A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTN3A2 Gene

Pathways & Interactions for BTN3A2 Gene

genes like me logo Genes that share pathways with BTN3A2: view

Pathways by source for BTN3A2 Gene

Gene Ontology (GO) - Biological Process for BTN3A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0002376 immune system process IEA --
GO:0002456 T cell mediated immunity IMP 22767497
GO:0050776 regulation of immune response IBA --
GO:0050852 T cell receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with BTN3A2: view

No data available for SIGNOR curated interactions for BTN3A2 Gene

Drugs & Compounds for BTN3A2 Gene

No Compound Related Data Available

Transcripts for BTN3A2 Gene

Unigene Clusters for BTN3A2 Gene

Butyrophilin, subfamily 3, member A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTN3A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5
SP2: -

Relevant External Links for BTN3A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN3A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTN3A2 Gene

mRNA differential expression in normal tissues according to GTEx for BTN3A2 Gene

This gene is overexpressed in Whole Blood (x5.4) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for BTN3A2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.9), Ovary (26.2), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN3A2 Gene

Protein tissue co-expression partners for BTN3A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTN3A2 Gene:


SOURCE GeneReport for Unigene cluster for BTN3A2 Gene:


mRNA Expression by UniProt/SwissProt for BTN3A2 Gene:

Tissue specificity: Detected in T-cells and natural killer cells.

Evidence on tissue expression from TISSUES for BTN3A2 Gene

  • Skin(4.5)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with BTN3A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTN3A2 Gene

Orthologs for BTN3A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN3A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTN3A2 33
  • 97.06 (n)
(Mus musculus)
Mammalia Btnl10 34
  • 33 (a)
(Bos Taurus)
Mammalia -- 34
  • 25 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 20 (a)
-- 34
  • 18 (a)
-- 34
  • 17 (a)
(Canis familiaris)
Mammalia -- 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 3 (a)
Species where no ortholog for BTN3A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN3A2 Gene

Gene Tree for BTN3A2 (if available)
Gene Tree for BTN3A2 (if available)
Evolutionary constrained regions (ECRs) for BTN3A2: view image

Paralogs for BTN3A2 Gene

Paralogs for BTN3A2 Gene

(14) SIMAP similar genes for BTN3A2 Gene using alignment to 6 proteins:

  • S4R3N0_HUMAN
genes like me logo Genes that share paralogs with BTN3A2: view

Variants for BTN3A2 Gene

Sequence variations from dbSNP and Humsavar for BTN3A2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000037255 -- 26,379,560(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000056196 -- 26,366,798(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000062323 -- 26,379,382(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000131219 -- 26,451,294(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000200032 -- 26,390,572(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTN3A2 Gene

Variant ID Type Subtype PubMed ID
esv2673332 CNV deletion 23128226
esv2731728 CNV deletion 23290073
esv2731730 CNV deletion 23290073
esv3608402 CNV loss 21293372
esv3608403 CNV loss 21293372
esv3608404 CNV gain 21293372
esv3608405 CNV loss 21293372
esv3890802 CNV loss 25118596
nsv1023453 CNV gain 25217958
nsv1030863 CNV gain+loss 25217958
nsv527328 CNV loss 19592680
nsv970085 CNV duplication 23825009
nsv970086 CNV duplication 23825009

Variation tolerance for BTN3A2 Gene

Residual Variation Intolerance Score: 83.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.70; 83.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTN3A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN3A2 Gene

Disorders for BTN3A2 Gene

Additional Disease Information for BTN3A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BTN3A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN3A2 Gene

Publications for BTN3A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4 58
  2. Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. (PMID: 9382921) Tazi-Ahnini R … Pontarotti P (Immunogenetics 1997) 3 4 22 58
  3. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. (PMID: 22767497) Harly C … Scotet E (Blood 2012) 3 4 58
  4. The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. (PMID: 22846996) Palakodeti A … Adams EJ (The Journal of biological chemistry 2012) 3 4 58
  5. Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. (PMID: 21918970) Messal N … Olive D (European journal of immunology 2011) 3 4 58

Products for BTN3A2 Gene

Sources for BTN3A2 Gene

Loading form....