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Aliases for BTN2A3P Gene

Aliases for BTN2A3P Gene

  • Butyrophilin Subfamily 2 Member A3, Pseudogene 2 3 5
  • BTN2A3 3 4
  • Butyrophilin, Subfamily 2, Member A3, Pseudogene 2
  • Butyrophilin, Subfamily 2, Member A Pseudogene 3
  • Butyrophilin, Subfamily 2, Member A3 2
  • BTN2.3 3

External Ids for BTN2A3P Gene

Previous HGNC Symbols for BTN2A3P Gene

  • BTN2A3

Previous GeneCards Identifiers for BTN2A3P Gene

  • GC06P026425
  • GC06P026426
  • GC06P026428
  • GC06P026430
  • GC06P026431
  • GC06P026432
  • GC06P026437
  • GC06P026509
  • GC06P026809
  • GC06P026911
  • GC06P027011

Summaries for BTN2A3P Gene

Entrez Gene Summary for BTN2A3P Gene

  • The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A3) and BTN3 (e.g., BNT3A1; MIM 613593) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

GeneCards Summary for BTN2A3P Gene

BTN2A3P (Butyrophilin Subfamily 2 Member A3, Pseudogene) is a Pseudogene.

Additional gene information for BTN2A3P Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN2A3P Gene

Genomics for BTN2A3P Gene

GeneHancer (GH) Regulatory Elements for BTN2A3P Gene

Promoters and enhancers for BTN2A3P Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026420 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 669.2 -0.1 -57 2.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 BRCA1 ZNF48 YY1 POLR2B BTN2A3P BTN3A3 BTN3A2 BTN2A1 BTN3A1 BTN2A2 ABT1 HMGN4
GH06J026422 Enhancer 0.5 Ensembl 650.7 +1.3 1310 0.2 ZNF316 MAFF MAFG EMSY MAFK BTN2A3P BTN3A3 BTN3A2
GH06J026019 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 61.2 -393.8 -393805 16.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HIST1H3B HIST1H4B HIST1H2AB ABT1 BTN2A1 BTN2A3P HMGN4 BTN2A2 ENSG00000272462 BTN3A2
GH06J027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 61.2 +716.6 716631 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GC06P027243 HIST1H4I HIST1H2BJ ZKSCAN8 ABT1 HMGN4 BTN2A2 BTN2A3P BTN2A1 ZNF322
GH06J026120 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 51 -297.4 -297417 7.8 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC SSRP1 HIST1H2AC HIST1H2BC PIR32750 PIR33095 PIR44445 ABT1 BTN2A3P HMGN4 BTN2A1 BTN2A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTN2A3P on UCSC Golden Path with GeneCards custom track

Genomic Locations for BTN2A3P Gene

Genomic Locations for BTN2A3P Gene
10,993 bases
Plus strand
10,993 bases
Plus strand

Genomic View for BTN2A3P Gene

Genes around BTN2A3P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN2A3P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN2A3P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN2A3P Gene

Proteins for BTN2A3P Gene

  • Protein details for BTN2A3P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative butyrophilin subfamily 2 member A3
    Protein Accession:
    Secondary Accessions:
    • A6NEF4

    Protein attributes for BTN2A3P Gene

    586 amino acids
    Molecular mass:
    65713 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC69644.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for BTN2A3P Gene

Post-translational modifications for BTN2A3P Gene

  • Glycosylation at Asn220, posLast=214214, posLast=112112, and posLast=4545
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTN2A3P Gene

Domains & Families for BTN2A3P Gene

Gene Families for BTN2A3P Gene

Suggested Antigen Peptide Sequences for BTN2A3P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN2A3P: view

Function for BTN2A3P Gene

Phenotypes From GWAS Catalog for BTN2A3P Gene

Gene Ontology (GO) - Molecular Function for BTN2A3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
genes like me logo Genes that share ontologies with BTN2A3P: view
genes like me logo Genes that share phenotypes with BTN2A3P: view

Animal Model Products

miRNA for BTN2A3P Gene

miRTarBase miRNAs that target BTN2A3P

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN2A3P Gene

Localization for BTN2A3P Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN2A3P Gene

Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for BTN2A3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTN2A3P: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for BTN2A3P Gene

Pathways & Interactions for BTN2A3P Gene

SuperPathways for BTN2A3P Gene

No Data Available

Interacting Proteins for BTN2A3P Gene

Selected Interacting proteins: Q96KV6-BT2A3_HUMAN for BTN2A3P Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for BTN2A3P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0050776 regulation of immune response IBA --
GO:0050852 T cell receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with BTN2A3P: view

No data available for Pathways by source and SIGNOR curated interactions for BTN2A3P Gene

Drugs & Compounds for BTN2A3P Gene

No Compound Related Data Available

Transcripts for BTN2A3P Gene

mRNA/cDNA for BTN2A3P Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTN2A3P Gene

Butyrophilin, subfamily 2, member A3, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A3P Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c
SP1: -

Relevant External Links for BTN2A3P Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN2A3P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTN2A3P Gene

Protein differential expression in normal tissues from HIPED for BTN2A3P Gene

This gene is overexpressed in Urine (47.5) and Adipocyte (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN2A3P Gene

Protein tissue co-expression partners for BTN2A3P Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTN2A3P Gene:


SOURCE GeneReport for Unigene cluster for BTN2A3P Gene:

genes like me logo Genes that share expression patterns with BTN2A3P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTN2A3P Gene

Orthologs for BTN2A3P Gene

Evolution for BTN2A3P Gene

Gene Tree for BTN2A3P (if available)
Gene Tree for BTN2A3P (if available)

No data available for Orthologs for BTN2A3P Gene

Paralogs for BTN2A3P Gene

(8) SIMAP similar genes for BTN2A3P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BTN2A3P: view

No data available for Paralogs for BTN2A3P Gene

Variants for BTN2A3P Gene

Sequence variations from dbSNP and Humsavar for BTN2A3P Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000520490 -- 26,422,407(+) T/A intron_variant
rs1000539073 -- 26,426,023(+) C/T intron_variant
rs1000590007 -- 26,425,595(+) G/T intron_variant
rs1000744464 -- 26,429,077(+) C/T intron_variant
rs1000976106 -- 26,422,758(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTN2A3P Gene

Variant ID Type Subtype PubMed ID
dgv5927n100 CNV gain 25217958
dgv5928n100 CNV loss 25217958
esv2731730 CNV deletion 23290073
esv2763996 CNV gain 21179565
esv3576106 CNV gain 25503493
esv3608402 CNV loss 21293372
esv3890802 CNV loss 25118596
nsv1017824 CNV gain+loss 25217958
nsv1023453 CNV gain 25217958
nsv477034 CNV novel sequence insertion 20440878
nsv601184 CNV gain 21841781
nsv969358 CNV duplication 23825009

Additional Variant Information for BTN2A3P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BTN2A3P Gene

Disorders for BTN2A3P Gene

Additional Disease Information for BTN2A3P

No disorders were found for BTN2A3P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN2A3P Gene

Publications for BTN2A3P Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  2. BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation. (PMID: 20208008) Smith IA … Trowsdale J (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for BTN2A3P Gene

Sources for BTN2A3P Gene

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