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Aliases for BTN2A2 Gene

Aliases for BTN2A2 Gene

  • Butyrophilin Subfamily 2 Member A2 2 3 3 5
  • BT2.2 3 4
  • BTF2 3 4
  • Butyrophilin, Subfamily 2, Member A2 2
  • Butyrophilin 2 3
  • BTN2.2 3

External Ids for BTN2A2 Gene

Previous GeneCards Identifiers for BTN2A2 Gene

  • GC06P026440
  • GC06P026445
  • GC06P026491
  • GC06P026383
  • GC06P026332

Summaries for BTN2A2 Gene

Entrez Gene Summary for BTN2A2 Gene

  • Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for BTN2A2 Gene

BTN2A2 (Butyrophilin Subfamily 2 Member A2) is a Protein Coding gene. Among its related pathways are Butyrophilin (BTN) family interactions and Innate Immune System. An important paralog of this gene is BTN2A1.

UniProtKB/Swiss-Prot for BTN2A2 Gene

  • Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.

Gene Wiki entry for BTN2A2 Gene

Additional gene information for BTN2A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTN2A2 Gene

Genomics for BTN2A2 Gene

GeneHancer (GH) Regulatory Elements for BTN2A2 Gene

Promoters and enhancers for BTN2A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J026382 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 747.2 +0.5 481 2.2 HDGF PKNOX1 FOXA2 ARNT FEZF1 YBX1 ZNF2 YY1 POLR2B E2F8 BTN2A2 ABT1 BTN2A1 HMGN4 BTN2A3P BTN3A1 TRIM38 GUSBP2 BTN3A2 ZNF391
GH06J027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 63.8 +755.1 755136 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC GC06P027243 HIST1H4I HIST1H2BJ ZKSCAN8 ABT1 HMGN4 BTN2A2 BTN2A3P BTN2A1 ZNF322
GH06J026019 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 57.3 -355.3 -355300 16.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HIST1H3B HIST1H4B HIST1H2AB ABT1 BTN2A1 BTN2A3P HMGN4 BTN2A2 ENSG00000272462 BTN3A2
GH06J026052 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 67.9 -327.6 -327583 5.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 GC06M026056 GC06M026057 GC06M026058 GC06M026059 GC06M026061 HIST1H1C ABT1 BTN2A1 HMGN4 BTN2A2
GH06J026120 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.8 -258.9 -258912 7.8 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC SSRP1 HIST1H2AC HIST1H2BC PIR32750 PIR33095 PIR44445 ABT1 BTN2A3P HMGN4 BTN2A1 BTN2A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTN2A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTN2A2 gene promoter:
  • Elk-1
  • p53
  • STAT3
  • MyoD
  • POU2F1
  • POU2F1a
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • En-1

Genomic Locations for BTN2A2 Gene

Genomic Locations for BTN2A2 Gene
11,989 bases
Plus strand
11,779 bases
Plus strand

Genomic View for BTN2A2 Gene

Genes around BTN2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTN2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTN2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTN2A2 Gene

Proteins for BTN2A2 Gene

  • Protein details for BTN2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin subfamily 2 member A2
    Protein Accession:
    Secondary Accessions:
    • A6NM84
    • B4DE97
    • B4DQ01
    • E9PH07
    • O00480

    Protein attributes for BTN2A2 Gene

    523 amino acids
    Molecular mass:
    59070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTN2A2 Gene


neXtProt entry for BTN2A2 Gene

Post-translational modifications for BTN2A2 Gene

  • N-glycosylated.
  • Glycosylation at posLast=226226, posLast=220220, posLast=118118, and Asn50
  • Ubiquitination at Lys513 and Lys105
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BTN2A2 Gene

Domains & Families for BTN2A2 Gene

Gene Families for BTN2A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTN2A2: view

Function for BTN2A2 Gene

Molecular function for BTN2A2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion.
GENATLAS Biochemistry:
butyrophilin subfamily 2,member A2,B box family of proteins,involved in cell proliferation and development

Phenotypes From GWAS Catalog for BTN2A2 Gene

Gene Ontology (GO) - Molecular Function for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTN2A2: view
genes like me logo Genes that share phenotypes with BTN2A2: view

Animal Model Products

CRISPR Products

Clone Products

  • R&D Systems cDNA Clones for BTN2A2 (BTN2A2/Butyrophilin 2A2)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTN2A2 Gene

Localization for BTN2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTN2A2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTN2A2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with BTN2A2: view

Pathways & Interactions for BTN2A2 Gene

genes like me logo Genes that share pathways with BTN2A2: view

Pathways by source for BTN2A2 Gene

Gene Ontology (GO) - Biological Process for BTN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0031324 negative regulation of cellular metabolic process ISS --
GO:0046007 negative regulation of activated T cell proliferation ISS --
GO:0050710 negative regulation of cytokine secretion ISS --
GO:0050776 regulation of immune response IBA --
genes like me logo Genes that share ontologies with BTN2A2: view

No data available for SIGNOR curated interactions for BTN2A2 Gene

Drugs & Compounds for BTN2A2 Gene

No Compound Related Data Available

Transcripts for BTN2A2 Gene

Unigene Clusters for BTN2A2 Gene

Butyrophilin, subfamily 2, member A2:
Representative Sequences:

CRISPR Products

Clone Products

  • R&D Systems cDNA Clones for BTN2A2 (BTN2A2/Butyrophilin 2A2)

Alternative Splicing Database (ASD) splice patterns (SP) for BTN2A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - - -
SP5: -
SP6: - - -
SP7: - -

Relevant External Links for BTN2A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTN2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTN2A2 Gene

Protein differential expression in normal tissues from HIPED for BTN2A2 Gene

This gene is overexpressed in Urine (57.2) and Heart (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTN2A2 Gene

Protein tissue co-expression partners for BTN2A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTN2A2 Gene:


SOURCE GeneReport for Unigene cluster for BTN2A2 Gene:


mRNA Expression by UniProt/SwissProt for BTN2A2 Gene:

Tissue specificity: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.

Evidence on tissue expression from TISSUES for BTN2A2 Gene

  • Nervous system(4.5)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with BTN2A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTN2A2 Gene

Orthologs for BTN2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTN2A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTN2A2 34 33
  • 99.36 (n)
(Canis familiaris)
Mammalia BTN2A2 33
  • 80.37 (n)
-- 34
  • 72 (a)
(Mus musculus)
Mammalia Btn2a2 16 34 33
  • 77.36 (n)
(Rattus norvegicus)
Mammalia Btn2a2 33
  • 76.08 (n)
(Bos Taurus)
Mammalia BTN2A1 33
  • 73.69 (n)
-- 34
  • 58 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
Species where no ortholog for BTN2A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTN2A2 Gene

Gene Tree for BTN2A2 (if available)
Gene Tree for BTN2A2 (if available)
Evolutionary constrained regions (ECRs) for BTN2A2: view image

Paralogs for BTN2A2 Gene

Paralogs for BTN2A2 Gene

(19) SIMAP similar genes for BTN2A2 Gene using alignment to 9 proteins:

  • C9IY66_HUMAN
  • C9J8J5_HUMAN
  • C9J8R3_HUMAN
  • F8WC65_HUMAN
  • H7C4E8_HUMAN
genes like me logo Genes that share paralogs with BTN2A2: view

Variants for BTN2A2 Gene

Sequence variations from dbSNP and Humsavar for BTN2A2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000200032 -- 26,390,572(+) G/A intron_variant
rs1001116931 -- 26,387,030(+) G/A intron_variant
rs1001396093 -- 26,393,260(+) G/A 3_prime_UTR_variant, intron_variant
rs1001826514 -- 26,386,842(+) A/C intron_variant
rs1002072402 -- 26,382,054(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BTN2A2 Gene

Variant ID Type Subtype PubMed ID
esv2731728 CNV deletion 23290073
esv2731730 CNV deletion 23290073
esv3608402 CNV loss 21293372
esv3608403 CNV loss 21293372
esv3608404 CNV gain 21293372
esv3890802 CNV loss 25118596
nsv1023453 CNV gain 25217958
nsv1030863 CNV gain+loss 25217958
nsv601184 CNV gain 21841781
nsv970087 CNV duplication 23825009

Variation tolerance for BTN2A2 Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTN2A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTN2A2 Gene

Disorders for BTN2A2 Gene

Additional Disease Information for BTN2A2

No disorders were found for BTN2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTN2A2 Gene

Publications for BTN2A2 Gene

  1. A 1.1-Mb transcript map of the hereditary hemochromatosis locus. (PMID: 9149941) Ruddy DA … Feder JN (Genome research 1997) 2 3 4 58
  2. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for BTN2A2 Gene

Sources for BTN2A2 Gene