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This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by ... See more...
Aliases for BTLA Gene
Aliases for BTLA Gene
External Ids for BTLA Gene
- HGNC: 21087
- Entrez Gene: 151888
- Ensembl: ENSG00000186265
- OMIM: 607925
- UniProtKB: Q7Z6A9
Previous GeneCards Identifiers for BTLA Gene
- GC03M113466
- GC03M113505
- GC03M113667
- GC03M112182
- GC03M109566
Summaries for BTLA Gene
-
This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
GeneCards Summary for BTLA Gene
BTLA (B And T Lymphocyte Associated) is a Protein Coding gene. Diseases associated with BTLA include Cone-Rod Dystrophy 1 and Rheumatoid Arthritis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
UniProtKB/Swiss-Prot Summary for BTLA Gene
-
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
Additional gene information for BTLA Gene
- HGNC(21087)
- Entrez Gene(151888)
- Ensembl(ENSG00000186265)
- OMIM(607925)
- UniProtKB(Q7Z6A9)
- Open Targets Platform(ENSG00000186265)
- Search for BTLA at DataMed
- Search for BTLA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTLA Gene
Genomics for BTLA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for BTLA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around BTLA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BTLA
- Top Transcription factor binding sites by QIAGEN in the BTLA gene promoter:
-
- Evi-1
- Meis-1
- Meis-1a
- Meis-1b
- Nkx2-5
- p53
- POU2F1
- POU2F1a
- RelA
- RORalpha2
Genomic Locations for BTLA Gene
Genomic Locations for BTLA Gene
- chr3:112,463,030-112,499,757
- (GRCh38/hg38)
- Size:
- 36,728 bases
- Orientation:
- Minus strand
- chr3:112,182,813-112,218,408
- (GRCh37/hg19)
- Size:
- 35,596 bases
- Orientation:
- Minus strand
Genomic View for BTLA Gene
Genes around BTLA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.2 by HGNC
- 3q13.2 by Entrez Gene
- 3q13.2 by Ensembl
BTLA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BTLA Gene
Proteins for BTLA Gene
-
Protein details for BTLA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7Z6A9-BTLA_HUMAN
- Recommended name:
- B- and T-lymphocyte attenuator
- Protein Accession:
- Q7Z6A9
- Q3B831
- Q3HS85
- Q6ZNH9
Protein attributes for BTLA Gene
- Size:
- 289 amino acids
- Molecular mass:
- 32834 Da
- Quaternary structure:
-
- Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). Interacts with TNFRSF14/HVEM (via cysteine-rich domain 1) (PubMed:15568026, PubMed:18193050, PubMed:19915044).
- SequenceCaution:
-
- Sequence=BAD18396.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for BTLA Gene
Post-translational modifications for BTLA Gene
- Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.
- N-glycosylated.
-
Glycosylation at Asn75, Asn94, and Asn110
- NX_Q7Z6A9 (NX_Q7Z6A9-1)
- Modification sites at PhosphoSitePlus
Other Protein References for BTLA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ BTLA Antibody
- NSJ Bioreagents BTLA Antibody / CD272
- HUABIO Anti-CD272 Antibody
-
BioLegend
- CD272 (BTLA) Antibody (344505)
- CD272 (BTLA) Antibody (344506)
- CD272 (BTLA) Antibody (344502)
- CD272 (BTLA) Antibody (344509)
- CD272 (BTLA) Antibody (344510)
- CD272 (BTLA) Antibody (344512)
- CD272 (BTLA) Antibody (344511)
- PerCP/Cyanine5.5 CD272 (BTLA) Antibody (344513)
- PerCP/Cyanine5.5 CD272 (BTLA) Antibody (344514)
- CD272 (BTLA) Antibody (344516)
- CD272 (BTLA) Antibody (344515)
- APC/Cyanine7 CD272 (BTLA) Antibody (344517)
- APC/Cyanine7 CD272 (BTLA) Antibody (344518)
- CD272 (BTLA) Antibody (344519)
- CD272 (BTLA) Antibody (344520)
- CD272 (BTLA) Antibody (344521)
- CD272 (BTLA) Antibody (344522)
- CD272 (BTLA) Antibody (344524)
- CD272 (BTLA) Antibody (344523)
- TotalSeq(TM)-A0170 CD272 (BTLA) Antibody
- GeneTex Anti-CD272 antibody
-
Custom Antibody ServicesOriGene Antibodies for BTLA
- CF505518
- CF505519
- CF505536
- CF505547
- CF505558
- CF505685
- CF505686
- CF505687
- CF505688
- CF505689
- CF812574
- CF812576
- CF812577
- CF812580
- CF812581
- CF812582
- CF812587
- TA305899
- TA308519
- TA313391
- TA326653
- TA349775
- TA505518
- TA505518S
- TA505519
- TA505519S
- TA505536
- TA505536S
- TA505547
- TA505547S
- TA505558
- TA505558S
- TA505685
- TA505685S
- TA505686
- TA505686S
- TA505687
- TA505687S
- TA505688
- TA505688S
- TA505689
- TA505689S
- TA812574
- TA812574S
- TA812576
- TA812576S
- TA812577
- TA812577S
- TA812580
- TA812580S
- TA812581
- TA812581S
- TA812582
- TA812582S
- TA812587
- TA812587S
- Novus Biologicals Antibodies for BTLA
-
Abcam antibodies for BTLA
- Invitrogen Antibodies for BTLA (AFLGC-BTLA)
- antibodies-online: Show 46 available BTLA Antibodies ranked by validation data
- Compare Top BTLA Antibodies
-
Recommended
- 83 WB Antibodies (anti-human)
- 35 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 43 WB Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for BTLA
-
Santa Cruz Biotechnology (SCBT) Antibodies for BTLA
- Sino Biological Antibodies for BTLA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for BTLA
- Origene Custom Protein Services for BTLA
- Sino Biological Recombinant Proteins for BTLA
- Sino Biological Cell Lysates for BTLA
- ProSpec Recombinant Proteins for BTLA
-
ProSci Proteins for BTLA
- B and T lymphocyte attenuator [96-831]
- B and T lymphocyte attenuator [96-832]
- Btla protein [96-977]
- Btla protein [96-978]
- B and T lymphocyte associated [91-510]
- B and T lymphocyte associated [90-423]
- B and T lymphocyte associated [90-424]
- B and T lymphocyte associated [96-067]
- B and T lymphocyte associated [91-881]
-
Abcam proteins for BTLA
Assay Products
- RayBiotech Custom Human BTLA/CD272 ELISA
- antibodies-online: Show 9 available BTLA Elisa Kits ranked by validation data
- Compare Top BTLA Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for BTLA
No data available for DME Specific Peptides for BTLA Gene
Domains & Families for BTLA Gene
Gene Families for BTLA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for BTLA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for BTLA Gene
- GenScript: Design optimal peptide antigens:
-
- B- and T-lymphocyte-associated protein (BTLA_HUMAN)
- cDNA FLJ75957, highly similar to Homo sapiens B and T lymphocyte associated (BTLA), mRNA (Q400G7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for BTLA Gene
Function for BTLA Gene
Molecular function for BTLA Gene
- UniProtKB/Swiss-Prot Function:
- Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044).
Phenotypes From GWAS Catalog for BTLA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 27152329 |
| GO:0038023 | signaling receptor activity | IBA | 21873635 |
Phenotypes for BTLA Gene
- MGI mutant phenotypes for BTLA:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for BTLA:
Animal Models for BTLA Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BTLA - Select products 50% OFF >
- * BTLA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BTLA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BTLA
-
Santa Cruz Biotechnology (SCBT) CRISPR for BTLA
miRNA for BTLA Gene
- miRTarBase miRNAs that target BTLA
-
- hsa-miR-335-5p (MIRT017901)
- hsa-miR-630 (MIRT054107)
- hsa-miR-150-3p (MIRT509540)
- hsa-miR-1261 (MIRT509541)
- hsa-miR-4536-5p (MIRT509542)
- hsa-miR-7-5p (MIRT509543)
- hsa-miR-4463 (MIRT509544)
- hsa-miR-1243 (MIRT509545)
- hsa-miR-5580-3p (MIRT509546)
- hsa-miR-186-5p (MIRT509547)
- hsa-miR-3133 (MIRT509548)
- hsa-miR-23c (MIRT611158)
- hsa-miR-23b-3p (MIRT611159)
- hsa-miR-23a-3p (MIRT611160)
- hsa-miR-130a-5p (MIRT611161)
- hsa-miR-499b-3p (MIRT611162)
- hsa-miR-499a-3p (MIRT611163)
- hsa-miR-8485 (MIRT611164)
- hsa-miR-2113 (MIRT615089)
- hsa-miR-143-5p (MIRT615090)
- hsa-miR-3944-5p (MIRT615091)
- hsa-miR-3121-5p (MIRT615092)
- hsa-miR-107 (MIRT629119)
- hsa-miR-103a-3p (MIRT629120)
- hsa-miR-6755-3p (MIRT636678)
- hsa-miR-6879-3p (MIRT636679)
- hsa-miR-1224-3p (MIRT636680)
- hsa-miR-500b-3p (MIRT636681)
- hsa-miR-4446-5p (MIRT723235)
- hsa-miR-5006-3p (MIRT723236)
- hsa-miR-4755-5p (MIRT723237)
- hsa-miR-6883-3p (MIRT723238)
- hsa-miR-6830-3p (MIRT723239)
- hsa-miR-3124-3p (MIRT723240)
- hsa-miR-3162-3p (MIRT723241)
- hsa-miR-323b-3p (MIRT723242)
- hsa-miR-6882-5p (MIRT723243)
- hsa-miR-1264 (MIRT723244)
- hsa-miR-1247-3p (MIRT761520)
- hsa-miR-1273g-3p (MIRT761912)
- hsa-miR-1827 (MIRT763016)
- hsa-miR-1910-3p (MIRT763265)
- hsa-miR-3612 (MIRT765887)
- hsa-miR-3929 (MIRT767759)
- hsa-miR-4252 (MIRT767976)
- hsa-miR-4327 (MIRT768662)
- hsa-miR-4419b (MIRT768755)
- hsa-miR-4478 (MIRT769506)
- hsa-miR-4537 (MIRT770130)
- hsa-miR-455-3p (MIRT770276)
- hsa-miR-4649-3p (MIRT770616)
- hsa-miR-4722-5p (MIRT771534)
- hsa-miR-4793-3p (MIRT772365)
- hsa-miR-485-5p (MIRT772594)
- hsa-miR-508-5p (MIRT773125)
- hsa-miR-6499-3p (MIRT776207)
- hsa-miR-650 (MIRT776645)
- hsa-miR-6511a-5p (MIRT776763)
- hsa-miR-6512-3p (MIRT776879)
- hsa-miR-6516-5p (MIRT777072)
- hsa-miR-665 (MIRT777532)
- hsa-miR-6720-5p (MIRT777725)
- hsa-miR-6746-5p (MIRT778215)
- hsa-miR-6771-5p (MIRT778672)
- hsa-miR-6808-5p (MIRT779647)
- hsa-miR-6849-3p (MIRT780249)
- hsa-miR-6884-5p (MIRT780982)
- hsa-miR-6893-5p (MIRT781180)
- hsa-miR-7160-5p (MIRT781590)
- hsa-miR-766-3p (MIRT781832)
- hsa-miR-7703 (MIRT781980)
- hsa-miR-940 (MIRT782874)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BTLA
- Browse OriGene Inhibitory RNA Products For BTLA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTLA
Clone Products
- Applied Biological Materials (abm): Clones for BTLA - Select products 50% OFF >
- * BTLA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226023
- MG226024
- MR226023
- MR226023L3
- MR226023L4
- MR226024
- MR226024L3
- MR226024L4
- RC219458
- RC219458L1
- RC219458L2
- RC219458L3
- RC219458L4
- RC220628
- RC220628L1
- RC220628L2
- RC220628L3
- RC220628L4
- RG219458
- RG220628
- RR205257
- RR205257L3
- RR205257L4
- MR226023L3V
- MR226023L4V
- MR226024L3V
- MR226024L4V
- RC219458L1V
- RC219458L2V
- RC219458L3V
- RC219458L4V
- RC220628L1V
- RC220628L2V
- RC220628L3V
- RC220628L4V
- RR205257L3V
- RR205257L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BTLA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTLA
Cell Line Products
-
Horizon Cell Lines for BTLA
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTLA Gene
Localization for BTLA Gene
Subcellular locations from UniProtKB/Swiss-Prot for BTLA Gene
- Cell membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTLA Gene
Pathways & Interactions for BTLA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | CD28 co-stimulation | ||
| 3 | Innate Immune System |
.61
|
|
Pathways by source for BTLA Gene
3 Reactome pathways for BTLA Gene
Interacting Proteins for BTLA Gene
GPS-Prot Interaction Network for BTLA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | IBA | 21873635 |
| GO:0031295 | T cell costimulation | TAS | -- |
No data available for SIGNOR curated interactions for BTLA Gene
Transcripts for BTLA Gene
mRNA/cDNA for BTLA Gene
- 2 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000334529 3126 nts (view in UCSC)
- ENST00000474965 556 nts (view in UCSC)
- ENST00000383680 726 nts (view in UCSC)
- ENST00000496584 531 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for BTLA - Select products 50% OFF >
- * BTLA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for BTLA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BTLA
-
Santa Cruz Biotechnology (SCBT) CRISPR for BTLA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BTLA
- Browse OriGene Inhibitory RNA Products For BTLA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTLA
Clone Products
- Applied Biological Materials (abm): Clones for BTLA - Select products 50% OFF >
- * BTLA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226023
- MG226024
- MR226023
- MR226023L3
- MR226023L4
- MR226024
- MR226024L3
- MR226024L4
- RC219458
- RC219458L1
- RC219458L2
- RC219458L3
- RC219458L4
- RC220628
- RC220628L1
- RC220628L2
- RC220628L3
- RC220628L4
- RG219458
- RG220628
- RR205257
- RR205257L3
- RR205257L4
- MR226023L3V
- MR226023L4V
- MR226024L3V
- MR226024L4V
- RC219458L1V
- RC219458L2V
- RC219458L3V
- RC219458L4V
- RC220628L1V
- RC220628L2V
- RC220628L3V
- RC220628L4V
- RR205257L3V
- RR205257L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for BTLA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTLA
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Relevant External Links for BTLA Gene
- GeneLoc Exon Structure for
- BTLA
Expression for BTLA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Mature B-Cells Peripheral Blood
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- Adipose (Muscoskeletal System)
This gene is overexpressed in Peripheral blood mononuclear cells (42.8) and Blymphocyte (15.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTLA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BTLA
SOURCE GeneReport for Unigene cluster for BTLA Gene:
Hs.445162Evidence on tissue expression from TISSUES for BTLA Gene
- Blood(4.6)
- Lymph node(3.1)
- Spleen(2.9)
- Intestine(2.3)
- Bone marrow(2.2)
Primer Products
-
OriGene qPCR primer pairs for BTLA
-
OriGene qPCR primer pairs and template standards for BTLA
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTLA Gene
Orthologs for BTLA Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | BTLA 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | BTLA 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | BTLA 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Btla 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Btla 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | BTLA 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | BTLA 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101732729 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | BTLA 31 |
|
OneToOne |
- Species where no ortholog for BTLA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for BTLA Gene
- ENSEMBL:
- Gene Tree for BTLA (if available)
- TreeFam:
- Gene Tree for BTLA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for BTLA: view image
Paralogs for BTLA Gene
No data available for Paralogs for BTLA Gene
Variants for BTLA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BTLA Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs16859633 | - | p.Ile124Val | |||
| rs2931761 | - | p.Arg157Ser | |||
| rs9288952 | - | p.Pro267Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4840n100 | CNV | gain | 25217958 |
| esv3333682 | CNV | insertion | 20981092 |
| esv3597411 | CNV | gain | 21293372 |
| nsv1005323 | CNV | gain | 25217958 |
| nsv3950 | CNV | insertion | 18451855 |
| nsv591293 | CNV | loss | 21841781 |
| nsv591294 | CNV | gain | 21841781 |
| nsv591300 | CNV | gain | 21841781 |
| nsv953246 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.07;
1.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BTLA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTLA Gene
Disorders for BTLA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cone-rod dystrophy 1 |
|
|
| rheumatoid arthritis |
|
|
| cone-rod dystrophy 2 |
|
|
| systemic lupus erythematosus |
|
|
Search BTLA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BTLA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for BTLA Gene
Publications for BTLA Gene
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. (PMID: 12796776) Watanabe N … Murphy KM (Nature immunology 2003) 2 3 4
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
- Association of BTLA gene polymorphisms with the risk of malignant breast cancer in Chinese women of Heilongjiang Province. (PMID: 19585237) Fu Z … Li D (Breast cancer research and treatment 2010) 3 41
- PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PMID: 20066438) Ishizaki Y … Hara T (Human genetics 2010) 3 41
- T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment. (PMID: 19915044) Cheung TC … Ware CF (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4
ExternalLinks
Products for BTLA Gene
- View all 23 R&D Systems BTLA (BTLA) Products
- View all 3 R&D Systems BTLA (BTLA) Proteins and Enzymes
- View all 17 R&D Systems BTLA (BTLA) Primary Antibodies
- View all R&D Systems BTLA (BTLA) Proteome Profiler Antibody Arrays
- View all 2 R&D Systems BTLA (BTLA) cDNA Clones
- Learn more about R&D Systems custom BTLA antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for BTLA
- CF505518
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- Browse OriGene ELISA Kits
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- OriGene qPCR primer pairs for BTLA
- OriGene qPCR primer pairs and template standards for BTLA
- OriGene CRISPR knockouts for BTLA
- MG226023
- MG226024
- MR226023
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- RC220628L2V
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- RC220628L4V
- RR205257L3V
- RR205257L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BTLA
- Sino Biological Human cDNA Clone for BTLA
- Sino Biological Recombinant Proteins for BTLA
- Sino Biological Cell Lysates for BTLA
- Sino Biological Antibodies for BTLA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for BTLA
- Novus Biologicals proteins and lysates for BTLA
- Browse Antibodies
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- Find your target
- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for BTLA (ie. gene expression, shRNA knockdown, CRISPR)
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- VectorBuilder CRISPR vectors for BTLA (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for BTLA CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for BTLA
- antibodies-online: Show 46 available BTLA Antibodies ranked by validation data
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- Recommended
- 83 WB Antibodies (anti-human)
- 35 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 43 WB Antibodies (anti-mouse)
- 15 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 9 available BTLA Elisa Kits ranked by validation data
- Compare Top BTLA Elisa Kits
- Quality Products:
- antibodies-online: Show 44 available BTLA Proteins ranked by validation data
- Compare Top BTLA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for BTLA
- Search Santa Cruz Biotechnology (SCBT) for BTLA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BTLA
- Custom Antibody ServicesProSci Antibodies for BTLA
- ProSci Proteins for BTLA
- B and T lymphocyte attenuator [96-831]
- B and T lymphocyte attenuator [96-832]
- Btla protein [96-977]
- Btla protein [96-978]
- B and T lymphocyte associated [91-510]
- B and T lymphocyte associated [90-423]
- B and T lymphocyte associated [90-424]
- B and T lymphocyte associated [96-067]
- B and T lymphocyte associated [91-881]
- Horizon Cell Lines for BTLA
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for BTLA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for BTLA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for BTLA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTLA
Sources for BTLA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB