The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008] See more...

Aliases for BTG4 Gene

Aliases for BTG4 Gene

  • BTG Anti-Proliferation Factor 4 2 3 5
  • BTG Family Member 4 2 3 4
  • PC3B 2 3 4
  • B-Cell Translocation Gene 4 2 3
  • Protein BTG4 3 4
  • Protein PC3b 3 4
  • APRO3 2 3
  • OOMD8 3
  • BTG4 5

External Ids for BTG4 Gene

Previous GeneCards Identifiers for BTG4 Gene

  • GC11M113691
  • GC11M112850
  • GC11M111372
  • GC11M110875
  • GC11M110843
  • GC11M107262
  • GC11M111467

Summaries for BTG4 Gene

Entrez Gene Summary for BTG4 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG4 Gene

BTG4 (BTG Anti-Proliferation Factor 4) is a Protein Coding gene. Diseases associated with BTG4 include Oocyte Maturation Defect 8. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is BTG3.

UniProtKB/Swiss-Prot Summary for BTG4 Gene

  • Shows marked antiproliferative activity, being able to induce G(1) arrest.

Gene Wiki entry for BTG4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTG4 Gene

Genomics for BTG4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for BTG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111514 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 250.7 -0.2 -167 0.6 SIN3A BMI1 RFX1 ELF3 PRDM10 CTCF PKNOX1 HOATZ BTG4 MIR34B MIR34C piR-39656 ENSG00000254980 LAYN
GH11J111512 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.7 +1.6 1633 2.2 CTCF GLIS2 POLR2A EZH2 ZNF335 ZBTB26 BTG4 HOATZ MIR34B MIR34C piR-39656 PPP2R1B LAYN LOC728196 ENSG00000254980 POU2AF1
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 -251.3 -251282 3.3 IKZF1 SSRP1 ZNF580 POLR2A NFIC ZIC2 YY1 SMAD5 SIN3A ZNF639 PPP2R1B HSALNG0087137 lnc-SIK2-3 ALG9 SIK2 PIH1D2 NKAPD1 LAYN BTG4 HOATZ
GH11J111375 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 9.2 +136.2 136247 5.1 BCLAF1 ZNF207 POLR2A IRF4 EBF1 CBFB SMARCA5 MAX TAF1 BHLHE40 POU2AF1 lnc-BTG4-3 COLCA1 COLCA2 ENSG00000255093 BTG4 HOATZ MIR34B MIR34C HSALNG0087098
GH11J111776 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 9.8 -263.1 -263146 2.7 ZNF654 CEBPA YY1 MXD4 CTCF REST ZNF592 TRIM22 KMT2B KDM6A PPP2R1B ENSG00000254990 HSALNG0087139 SIK2 ENSG00000255093 POU2AF1 BTG4 HOATZ MIR34B MIR34C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTG4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for BTG4

Top Transcription factor binding sites by QIAGEN in the BTG4 gene promoter:
  • C/EBPalpha
  • Nkx6-1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for BTG4 Gene

Latest Assembly
chr11:111,383,828-111,514,734
(GRCh38/hg38)
Size:
130,907 bases
Orientation:
Minus strand

Previous Assembly
chr11:111,338,251-111,385,450
(GRCh37/hg19 by Entrez Gene)
Size:
47,200 bases
Orientation:
Minus strand

chr11:111,338,251-111,383,079
(GRCh37/hg19 by Ensembl)
Size:
44,829 bases
Orientation:
Minus strand

Genomic View for BTG4 Gene

Genes around BTG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG4 Gene

Proteins for BTG4 Gene

  • Protein details for BTG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY30-BTG4_HUMAN
    Recommended name:
    Protein BTG4
    Protein Accession:
    Q9NY30
    Secondary Accessions:
    • Q8NEH7

    Protein attributes for BTG4 Gene

    Size:
    223 amino acids
    Molecular mass:
    25970 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTG4 Gene

Post-translational modifications for BTG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for BTG4
  • Santa Cruz Biotechnology (SCBT) Antibodies for BTG4

No data available for DME Specific Peptides for BTG4 Gene

Domains & Families for BTG4 Gene

Gene Families for BTG4 Gene

Protein Domains for BTG4 Gene

InterPro:
Blocks:
  • Anti-proliferative protein

Suggested Antigen Peptide Sequences for BTG4 Gene

GenScript: Design optimal peptide antigens:
  • Protein PC3b (BTG4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NY30

UniProtKB/Swiss-Prot:

BTG4_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG4: view

Function for BTG4 Gene

Molecular function for BTG4 Gene

UniProtKB/Swiss-Prot Function:
Shows marked antiproliferative activity, being able to induce G(1) arrest.

Phenotypes From GWAS Catalog for BTG4 Gene

genes like me logo Genes that share phenotypes with BTG4: view

Human Phenotype Ontology for BTG4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTG4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTG4 Gene

Localization for BTG4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTG4 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with BTG4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG4 Gene

Pathways & Interactions for BTG4 Gene

PathCards logo

SuperPathways for BTG4 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG4: view

Pathways by source for BTG4 Gene

1 KEGG pathway for BTG4 Gene

Gene Ontology (GO) - Biological Process for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 10995567
GO:0008285 negative regulation of cell proliferation IEA,TAS 10995567
GO:0030182 neuron differentiation TAS 10995567
GO:0045930 negative regulation of mitotic cell cycle IBA 21873635
genes like me logo Genes that share ontologies with BTG4: view

No data available for SIGNOR curated interactions for BTG4 Gene

Drugs & Compounds for BTG4 Gene

No Compound Related Data Available

Transcripts for BTG4 Gene

mRNA/cDNA for BTG4 Gene

4 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTG4

Alternative Splicing Database (ASD) splice patterns (SP) for BTG4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP2:
SP3: -

Relevant External Links for BTG4 Gene

GeneLoc Exon Structure for
BTG4

Expression for BTG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BTG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for BTG4 Gene

This gene is overexpressed in Testis (x47.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTG4 Gene



Protein tissue co-expression partners for BTG4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for BTG4

SOURCE GeneReport for Unigene cluster for BTG4 Gene:

Hs.128180

mRNA Expression by UniProt/SwissProt for BTG4 Gene:

Q9NY30-BTG4_HUMAN
Tissue specificity: Highly expressed in testis and in olfactory epithelium.
genes like me logo Genes that share expression patterns with BTG4: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTG4 Gene

Orthologs for BTG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia BTG4 29 30
  • 99.55 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia BTG4 29 30
  • 87.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia BTG4 29 30
  • 87.03 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Btg4 29 16 30
  • 77.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia BTG4 30
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia BTG4 30
  • 52 (a)
OneToOne
Chicken
(Gallus gallus)
Aves BTG4 29 30
  • 64.63 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia BTG4 30
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia btg4 29
  • 63.52 (n)
Str.3682 29
African clawed frog
(Xenopus laevis)
Amphibia LOC397913 29
Zebrafish
(Danio rerio)
Actinopterygii btg4 29 30
  • 58.33 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Tob 30
  • 9 (a)
OneToMany
Species where no ortholog for BTG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for BTG4 Gene

ENSEMBL:
Gene Tree for BTG4 (if available)
TreeFam:
Gene Tree for BTG4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BTG4: view image
Alliance of Genome Resources:
Additional Orthologs for BTG4

Paralogs for BTG4 Gene

Paralogs for BTG4 Gene

(4) SIMAP similar genes for BTG4 Gene using alignment to 2 proteins:

  • BTG4_HUMAN
  • E9PRM5_HUMAN

Pseudogenes.org Pseudogenes for BTG4 Gene

genes like me logo Genes that share paralogs with BTG4: view

Variants for BTG4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for BTG4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
977514 Pathogenic: Oocyte maturation defect 8 111,498,611(-) C/T
NM_017589.4(BTG4):c.166G>A (p.Ala56Thr)
MISSENSE
977515 Pathogenic: Oocyte maturation defect 8 111,498,704(-) G/A
NM_017589.4(BTG4):c.73C>T (p.Gln25Ter)
NONSENSE
977516 Pathogenic: Oocyte maturation defect 8 111,498,776(-) T/C
NM_017589.4(BTG4):c.1A>G (p.Met1Val)
INITIATIOR_CODON_VARIANT,MISSENSE
977517 Pathogenic: Oocyte maturation defect 8 111,497,242(-) GGAAT/G
NM_017589.4(BTG4):c.475_478del (p.Ile159fs)
FRAMESHIFT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for BTG4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for BTG4 Gene

Variant ID Type Subtype PubMed ID
nsv472582 CNV novel sequence insertion 20440878
nsv832268 CNV loss 17160897

Variation tolerance for BTG4 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTG4
Leiden Open Variation Database (LOVD)
BTG4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG4 Gene

Disorders for BTG4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BTG4 Gene - From: OMI, CVR, and GCD

Disorder Aliases PubMed IDs
oocyte maturation defect 8
  • oomd8
- elite association - COSMIC cancer census association via MalaCards
Search BTG4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BTG4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with BTG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BTG4 Gene

Publications for BTG4 Gene

  1. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PMID: 10995567) Buanne P … Tirone F (Genomics 2000) 2 3 4
  2. Homozygous Mutations in BTG4 Cause Zygotic Cleavage Failure and Female Infertility. (PMID: 32502391) Zheng W … Sang Q (American journal of human genetics 2020) 3 72
  3. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. (PMID: 20309940) Xu Y … Hu Z (International journal of cancer 2011) 3 40
  4. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PMID: 15672409) Auer RL … Cotter FE (Genes, chromosomes & cancer 2005) 3 22
  5. BTG4 is A Novel p53 Target Gene That Inhibits Cell Growth and Induces Apoptosis. (PMID: 32093041) Zhang N … Bu Y (Genes 2020) 3

Products for BTG4 Gene

Sources for BTG4 Gene