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Aliases for BTG4 Gene

Aliases for BTG4 Gene

  • BTG Anti-Proliferation Factor 4 2 3 5
  • BTG Family Member 4 2 3 4
  • B-Cell Translocation Gene 4 2 3
  • Protein PC3b 3 4
  • PC3B 3 4
  • Protein BTG4 3
  • APRO3 3

External Ids for BTG4 Gene

Previous GeneCards Identifiers for BTG4 Gene

  • GC11M113691
  • GC11M112850
  • GC11M111372
  • GC11M110875
  • GC11M110843
  • GC11M107262
  • GC11M111467

Summaries for BTG4 Gene

Entrez Gene Summary for BTG4 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG4 Gene

BTG4 (BTG Anti-Proliferation Factor 4) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is BTG3.

UniProtKB/Swiss-Prot for BTG4 Gene

  • Shows marked antiproliferative activity, being able to induce G(1) arrest.

Gene Wiki entry for BTG4 Gene

Additional gene information for BTG4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG4 Gene

Genomics for BTG4 Gene

GeneHancer (GH) Regulatory Elements for BTG4 Gene

Promoters and enhancers for BTG4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111512 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.7 +1.6 1571 1.5 ZNF148 CTCF ZNF335 GLIS2 POLR2A ZBTB26 EZH2 GC11P111545 GC11P111549 MIR34C MIR34B GC11P111550 GC11P111548 GC11P111546 GC11P111544 C11orf88 BTG4
GH11J111514 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 650.7 +0.0 3 0.9 CTCF ELF3 PKNOX1 RFX1 SIN3A BMI1 ZNF148 POLR2A PRDM10 C11orf88 BTG4 GC11P111546 MIR34B MIR34C GC11P111550 GC11P111549 GC11P111548 GC11P111545 GC11P111544
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.8 -251.3 -251283 3.3 ZNF493 ARID4B SIN3A ZNF48 YY1 ZNF121 POLR2B GLIS2 RUNX3 ZNF202 PPP2R1B ALG9 SIK2 PIH1D2 NKAPD1 LAYN MIR34C MIR34B C11orf88 BTG4
GH11J111776 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 9.8 -263.1 -263147 2.7 HDGF FOXA2 PKNOX1 SMAD1 ARID4B DMAP1 YY1 ARID2 ZNF143 ATF7 PPP2R1B ENSG00000254990 SIK2 LOC644277 POU2AF1 MIR34C MIR34B C11orf88 BTG4 ENSG00000254980
GH11J111375 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 9.2 +136.2 136246 5.1 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ZNF143 POU2AF1 COLCA1 COLCA2 LOC644277 BTG4 C11orf88 MIR34B MIR34C RNU2-60P MIR4491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTG4 gene promoter:
  • POU2F1
  • Nkx6-1
  • C/EBPalpha
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for BTG4 Gene

Genomic Locations for BTG4 Gene
130,639 bases
Minus strand
44,829 bases
Minus strand

Genomic View for BTG4 Gene

Genes around BTG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG4 Gene

Proteins for BTG4 Gene

  • Protein details for BTG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BTG4
    Protein Accession:
    Secondary Accessions:
    • Q8NEH7

    Protein attributes for BTG4 Gene

    223 amino acids
    Molecular mass:
    25970 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTG4 Gene


neXtProt entry for BTG4 Gene

Post-translational modifications for BTG4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for BTG4
  • Boster Bio Antibodies for BTG4
  • Santa Cruz Biotechnology (SCBT) Antibodies for BTG4

No data available for DME Specific Peptides for BTG4 Gene

Domains & Families for BTG4 Gene

Gene Families for BTG4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BTG4 Gene

Suggested Antigen Peptide Sequences for BTG4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG4: view

Function for BTG4 Gene

Molecular function for BTG4 Gene

UniProtKB/Swiss-Prot Function:
Shows marked antiproliferative activity, being able to induce G(1) arrest.

Phenotypes From GWAS Catalog for BTG4 Gene

genes like me logo Genes that share phenotypes with BTG4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTG4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BTG4 Gene

Localization for BTG4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTG4 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with BTG4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG4 Gene

Pathways & Interactions for BTG4 Gene

SuperPathway Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with BTG4: view

Pathways by source for BTG4 Gene

1 KEGG pathway for BTG4 Gene

Interacting Proteins for BTG4 Gene

Gene Ontology (GO) - Biological Process for BTG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest TAS 10995567
GO:0008285 negative regulation of cell proliferation TAS,IEA 10995567
GO:0030182 neuron differentiation TAS 10995567
GO:0045930 negative regulation of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with BTG4: view

No data available for SIGNOR curated interactions for BTG4 Gene

Drugs & Compounds for BTG4 Gene

No Compound Related Data Available

Transcripts for BTG4 Gene

mRNA/cDNA for BTG4 Gene

(12) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG4 Gene

B-cell translocation gene 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for BTG4

Alternative Splicing Database (ASD) splice patterns (SP) for BTG4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7
SP1: -
SP3: -

Relevant External Links for BTG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTG4 Gene

mRNA differential expression in normal tissues according to GTEx for BTG4 Gene

This gene is overexpressed in Testis (x47.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTG4 Gene

Protein tissue co-expression partners for BTG4 Gene

NURSA nuclear receptor signaling pathways regulating expression of BTG4 Gene:


SOURCE GeneReport for Unigene cluster for BTG4 Gene:


mRNA Expression by UniProt/SwissProt for BTG4 Gene:

Tissue specificity: Highly expressed in testis and in olfactory epithelium.
genes like me logo Genes that share expression patterns with BTG4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTG4 Gene

Orthologs for BTG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTG4 34 33
  • 99.55 (n)
(Canis familiaris)
Mammalia BTG4 34 33
  • 87.33 (n)
(Bos Taurus)
Mammalia BTG4 34 33
  • 87.03 (n)
(Mus musculus)
Mammalia Btg4 16 34 33
  • 77.98 (n)
(Monodelphis domestica)
Mammalia BTG4 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia BTG4 34
  • 52 (a)
(Gallus gallus)
Aves BTG4 34 33
  • 64.63 (n)
(Anolis carolinensis)
Reptilia BTG4 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btg4 33
  • 63.52 (n)
Str.3682 33
African clawed frog
(Xenopus laevis)
Amphibia LOC397913 33
(Danio rerio)
Actinopterygii btg4 34 33
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tob 34
  • 9 (a)
Species where no ortholog for BTG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG4 Gene

Gene Tree for BTG4 (if available)
Gene Tree for BTG4 (if available)
Evolutionary constrained regions (ECRs) for BTG4: view image

Paralogs for BTG4 Gene

Paralogs for BTG4 Gene

(4) SIMAP similar genes for BTG4 Gene using alignment to 2 proteins:

  • E9PRM5_HUMAN Pseudogenes for BTG4 Gene

genes like me logo Genes that share paralogs with BTG4: view

Variants for BTG4 Gene

Sequence variations from dbSNP and Humsavar for BTG4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000032601 -- 111,462,038(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000063570 -- 111,480,979(-) A/G intron_variant
rs1000115612 -- 111,416,937(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000132707 -- 111,433,919(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000156439 -- 111,497,002(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTG4 Gene

Variant ID Type Subtype PubMed ID
nsv472582 CNV novel sequence insertion 20440878
nsv832268 CNV loss 17160897

Variation tolerance for BTG4 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTG4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG4 Gene

Disorders for BTG4 Gene

Additional Disease Information for BTG4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BTG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG4 Gene

Publications for BTG4 Gene

  1. Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (PMID: 10995567) Buanne P … Tirone F (Genomics 2000) 2 3 4 58
  2. A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. (PMID: 20309940) Xu Y … Hu Z (International journal of cancer 2011) 3 44 58
  3. Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. (PMID: 15672409) Auer RL … Cotter FE (Genes, chromosomes & cancer 2005) 3 22 58
  4. Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. (PMID: 19576178) Dong W … Wang L (Biochemical and biophysical research communications 2009) 3 58
  5. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (PMID: 18519671) Toyota M … Tokino T (Cancer research 2008) 3 58

Products for BTG4 Gene

Sources for BTG4 Gene

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