The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008] See more...

Aliases for BTG2 Gene

Aliases for BTG2 Gene

  • BTG Anti-Proliferation Factor 2 2 3 5
  • NGF-Inducible Anti-Proliferative Protein PC3 2 3 4
  • BTG Family Member 2 2 3 4
  • Nerve Growth Factor-Inducible Anti-Proliferative 2 3
  • B-Cell Translocation Gene 2 2 3
  • Pheochromacytoma Cell-3 2 3
  • Protein BTG2 3 4
  • PC3 3 4
  • BTG Family, Member 2 2
  • APRO1 3
  • TIS21 3

External Ids for BTG2 Gene

Previous GeneCards Identifiers for BTG2 Gene

  • GC01P200954
  • GC01P198712
  • GC01P199741
  • GC01P200562
  • GC01P200006
  • GC01P201542
  • GC01P203274
  • GC01P174439

Summaries for BTG2 Gene

Entrez Gene Summary for BTG2 Gene

  • The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for BTG2 Gene

BTG2 (BTG Anti-Proliferation Factor 2) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is BTG1.

UniProtKB/Swiss-Prot Summary for BTG2 Gene

  • Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.

Gene Wiki entry for BTG2 Gene

Additional gene information for BTG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for BTG2 Gene

Genomics for BTG2 Gene

GeneHancer (GH) Regulatory Elements for BTG2 Gene

Promoters and enhancers for BTG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTG2 gene promoter:
  • NF-kappaB
  • NF-kappaB1
  • p53
  • SRF
  • SRF (504 AA)
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for BTG2 Gene

Genomic Locations for BTG2 Gene
chr1:203,305,491-203,309,602
(GRCh38/hg38)
Size:
4,112 bases
Orientation:
Plus strand
chr1:203,274,619-203,278,730
(GRCh37/hg19)
Size:
4,112 bases
Orientation:
Plus strand

Genomic View for BTG2 Gene

Genes around BTG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG2 Gene

Proteins for BTG2 Gene

  • Protein details for BTG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78543-BTG2_HUMAN
    Recommended name:
    Protein BTG2
    Protein Accession:
    P78543
    Secondary Accessions:
    • A0A024R986
    • Q3KR25
    • Q5VUT0

    Protein attributes for BTG2 Gene

    Size:
    158 amino acids
    Molecular mass:
    17416 Da
    Quaternary structure:
    • Interacts with PRKCABP (By similarity). Interacts with CNOT7 and CNOT8; indicative for an association with the CCR4-NOT complex. Interacts with PIN1, inducing mitochondrial depolarization.

    Three dimensional structures from OCA and Proteopedia for BTG2 Gene

neXtProt entry for BTG2 Gene

Post-translational modifications for BTG2 Gene

  • Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for BTG2
  • Santa Cruz Biotechnology (SCBT) Antibodies for BTG2

No data available for DME Specific Peptides for BTG2 Gene

Domains & Families for BTG2 Gene

Gene Families for BTG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for BTG2 Gene

Suggested Antigen Peptide Sequences for BTG2 Gene

GenScript: Design optimal peptide antigens:
  • NGF-inducible anti-proliferative protein PC3 (BTG2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78543

UniProtKB/Swiss-Prot:

BTG2_HUMAN :
  • Belongs to the BTG family.
Family:
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG2: view

Function for BTG2 Gene

Molecular function for BTG2 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.
GENATLAS Biochemistry:
B cell transition gene 2,preferentially expressed in quiescent cells,antiproliferative p53 dependent component of the DNA damage cellular response pathway,homolog to murine Pc3/Tis21 and human BTG1 (see symbol),at the onset of neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating division,Tob/BTG1 family

Phenotypes From GWAS Catalog for BTG2 Gene

Gene Ontology (GO) - Molecular Function for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0005515 protein binding IPI 9712883
genes like me logo Genes that share ontologies with BTG2: view
genes like me logo Genes that share phenotypes with BTG2: view

Animal Models for BTG2 Gene

MGI Knock Outs for BTG2:
  • Btg2 Btg2<tm1Wbh>
  • Btg2 Btg2<tm1b(KOMP)Mbp>
  • Btg2 Btg2<tm1Spo>

Animal Model Products

CRISPR Products

miRNA for BTG2 Gene

miRTarBase miRNAs that target BTG2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG2 Gene

Localization for BTG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTG2 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 2
mitochondrion 2
plasma membrane 0
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with BTG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG2 Gene

Pathways & Interactions for BTG2 Gene

genes like me logo Genes that share pathways with BTG2: view

Pathways by source for BTG2 Gene

SIGNOR curated interactions for BTG2 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BTG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006281 DNA repair TAS 8944033
GO:0006479 protein methylation IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 8944033
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
genes like me logo Genes that share ontologies with BTG2: view

Drugs & Compounds for BTG2 Gene

(1) Drugs for BTG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BTG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BTG2: view

Transcripts for BTG2 Gene

mRNA/cDNA for BTG2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(470) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG2 Gene

No ASD Table

Relevant External Links for BTG2 Gene

GeneLoc Exon Structure for
BTG2
ECgene alternative splicing isoforms for
BTG2

Expression for BTG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG2 Gene

This gene is overexpressed in Fallopian Tube (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of BTG2 Gene:

BTG2

SOURCE GeneReport for Unigene cluster for BTG2 Gene:

Hs.519162

Evidence on tissue expression from TISSUES for BTG2 Gene

  • Nervous system(3.8)
  • Muscle(3.2)
  • Adrenal gland(2.8)
  • Lung(2.6)
  • Pancreas(2.5)
  • Eye(2.4)
  • Kidney(2.3)
  • Intestine(2.2)
  • Blood(2.1)
  • Bone marrow(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with BTG2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTG2 Gene

Orthologs for BTG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTG2 33 32
  • 99.79 (n)
OneToOne
dog
(Canis familiaris)
Mammalia BTG2 33 32
  • 90.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Btg2 17 33 32
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Btg2 32
  • 89.66 (n)
cow
(Bos Taurus)
Mammalia BTG2 33 32
  • 88.67 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTG2 33
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTG2 33 32
  • 80.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTG2 33
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btg2 32
  • 61.45 (n)
MGC75753 32
zebrafish
(Danio rerio)
Actinopterygii btg2 33 32
  • 65.19 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tob 33
  • 10 (a)
OneToMany
Species where no ortholog for BTG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG2 Gene

ENSEMBL:
Gene Tree for BTG2 (if available)
TreeFam:
Gene Tree for BTG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BTG2: view image

Paralogs for BTG2 Gene

Paralogs for BTG2 Gene

(5) SIMAP similar genes for BTG2 Gene using alignment to 1 proteins:

  • BTG2_HUMAN
genes like me logo Genes that share paralogs with BTG2: view

Variants for BTG2 Gene

Sequence variations from dbSNP and Humsavar for BTG2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs869320634 uncertain-significance, not provided 203,307,382(+) G/A coding_sequence_variant, missense_variant
rs1000200665 -- 203,305,534(+) G/A 5_prime_UTR_variant
rs1000938390 -- 203,306,925(+) T/G intron_variant
rs1001236061 -- 203,304,477(+) C/T upstream_transcript_variant
rs1002919340 -- 203,305,245(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BTG2 Gene

Variant ID Type Subtype PubMed ID
esv2721696 CNV deletion 23290073

Variation tolerance for BTG2 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTG2 Gene

Human Gene Mutation Database (HGMD)
BTG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG2 Gene

Disorders for BTG2 Gene

Additional Disease Information for BTG2

No disorders were found for BTG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTG2 Gene

Publications for BTG2 Gene

  1. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. (PMID: 8944033) Rouault JP … Puisieux A (Nature genetics 1996) 2 3 4 23 56
  2. The BTG2 protein is a general activator of mRNA deadenylation. (PMID: 18337750) Mauxion F … Séraphin B (The EMBO journal 2008) 3 4 23 56
  3. Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity. (PMID: 18974182) Yang X … Rao Z (Nucleic acids research 2008) 3 4 23 56
  4. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. (PMID: 12771185) Morel AP … Corbo L (Journal of cell science 2003) 3 4 23 56
  5. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prévôt D … Corbo L (The Journal of biological chemistry 2001) 3 4 23 56

Products for BTG2 Gene

Sources for BTG2 Gene