Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BTG1 Gene

Aliases for BTG1 Gene

  • BTG Anti-Proliferation Factor 1 2 3 5
  • B-Cell Translocation Gene 1, Anti-Proliferative 2 3
  • B-Cell Translocation Gene 1 Protein 3 4
  • Protein BTG1 3
  • APRO2 3

External Ids for BTG1 Gene

Previous GeneCards Identifiers for BTG1 Gene

  • GC12M091929
  • GC12M092827
  • GC12M092469
  • GC12M091039
  • GC12M089601

Summaries for BTG1 Gene

Entrez Gene Summary for BTG1 Gene

  • This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]

GeneCards Summary for BTG1 Gene

BTG1 (BTG Anti-Proliferation Factor 1) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and Diurnally Regulated Genes with Circadian Orthologs. Gene Ontology (GO) annotations related to this gene include enzyme binding and transcription coregulator activity. An important paralog of this gene is BTG2.

UniProtKB/Swiss-Prot for BTG1 Gene

  • Anti-proliferative protein.

Gene Wiki entry for BTG1 Gene

Additional gene information for BTG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTG1 Gene

Genomics for BTG1 Gene

GeneHancer (GH) Regulatory Elements for BTG1 Gene

Promoters and enhancers for BTG1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J092130 Promoter/Enhancer 3.2 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.8 +5.2 5168 20.3 CLOCK FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC BTG1 EEA1 LOC101928617 LINC01619 GC12P092143 GC12P092067 LINC02391
GH12J092123 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 26.8 +21.1 21104 2.4 ZNF680 HLF MAX CEBPB CEBPG REST EP300 YY1 ATF4 POLR2A BTG1 LINC01619 GC12P092067
GH12J092549 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.1 -408.9 -408939 10.5 HDGF PKNOX1 SMAD1 IRF4 YY1 ZNF207 ZNF143 ATF7 FOS RUNX3 BTG1 LOC101928617 EEA1 LOC105369905 LOC100132126
GH12J092028 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +112.9 112946 8 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 YBX1 BTG1 LOC101928617 CLLU1 GC12P092067 LOC105369901 LINC01619
GH12J092561 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -415.8 -415822 1.3 FOXA2 SMAD1 RAD21 YY1 EGR1 ZNF143 ATF7 IKZF2 RUNX3 SMARCA5 BTG1 LOC101928617 LOC105369905 C12orf74
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTG1 gene promoter:
  • AP-1
  • AML1a

Genomic Locations for BTG1 Gene

Genomic Locations for BTG1 Gene
5,620 bases
Minus strand
5,620 bases
Minus strand

Genomic View for BTG1 Gene

Genes around BTG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTG1 Gene

Proteins for BTG1 Gene

  • Protein details for BTG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BTG1
    Protein Accession:
    Secondary Accessions:
    • P31607

    Protein attributes for BTG1 Gene

    171 amino acids
    Molecular mass:
    19209 Da
    Quaternary structure:
    • Interacts with CNOT7 and CNOT8.

neXtProt entry for BTG1 Gene

Post-translational modifications for BTG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BTG1 Gene

Domains & Families for BTG1 Gene

Gene Families for BTG1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for BTG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BTG family.
  • Belongs to the BTG family.
genes like me logo Genes that share domains with BTG1: view

Function for BTG1 Gene

Molecular function for BTG1 Gene

UniProtKB/Swiss-Prot Function:
Anti-proliferative protein.
GENATLAS Biochemistry:
B cell translocation gene 1,widely expressed except in brain and muscle,maximally expressed in the G0/G1 phases of the cell cycle,involved in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22),negative regulator of cell proliferation (antiproliferative),putative tumor suppressor gene,Tob/BTG1 family

Phenotypes From GWAS Catalog for BTG1 Gene

Gene Ontology (GO) - Molecular Function for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity NAS 11420681
GO:0005515 protein binding IPI 9712883
GO:0019899 enzyme binding IPI 8663146
GO:0019900 kinase binding NAS 9820826
genes like me logo Genes that share ontologies with BTG1: view
genes like me logo Genes that share phenotypes with BTG1: view

Animal Models for BTG1 Gene

MGI Knock Outs for BTG1:
  • Btg1 Btg1<tm1Ftir>

Animal Model Products

miRNA for BTG1 Gene

miRTarBase miRNAs that target BTG1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTG1 Gene

Localization for BTG1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTG1 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP,IEA 11420681
GO:0005737 cytoplasm IMP,IDA 11420681
genes like me logo Genes that share ontologies with BTG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BTG1 Gene

Pathways & Interactions for BTG1 Gene

genes like me logo Genes that share pathways with BTG1: view

Pathways by source for BTG1 Gene

1 BioSystems pathway for BTG1 Gene
1 KEGG pathway for BTG1 Gene
1 Qiagen pathway for BTG1 Gene

Gene Ontology (GO) - Biological Process for BTG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 11420681
GO:0006479 protein methylation IEA --
GO:0006979 response to oxidative stress IEA --
GO:0007283 spermatogenesis IEA --
GO:0008285 negative regulation of cell proliferation IDA,IEA 1373383
genes like me logo Genes that share ontologies with BTG1: view

No data available for SIGNOR curated interactions for BTG1 Gene

Drugs & Compounds for BTG1 Gene

(1) Drugs for BTG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for BTG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BTG1: view

Transcripts for BTG1 Gene

mRNA/cDNA for BTG1 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(1028) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTG1 Gene

B-cell translocation gene 1, anti-proliferative:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTG1 Gene

No ASD Table

Relevant External Links for BTG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BTG1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for BTG1 Gene

This gene is overexpressed in CD8 Tcells (52.2) and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for BTG1 Gene

Protein tissue co-expression partners for BTG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTG1 Gene:


SOURCE GeneReport for Unigene cluster for BTG1 Gene:


Evidence on tissue expression from TISSUES for BTG1 Gene

  • Intestine(4.6)
  • Skin(4.5)
  • Lung(4.4)
  • Pancreas(4.4)
  • Nervous system(4.3)
  • Eye(3.1)
  • Liver(2.9)
  • Kidney(2.7)
  • Heart(2.5)
  • Bone marrow(2.3)
  • Blood(2.2)
  • Lymph node(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with BTG1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTG1 Gene

Orthologs for BTG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BTG1 34 33
  • 100 (n)
(Mus musculus)
Mammalia Btg1 16 34 33
  • 96.88 (n)
4930525M21RIK 34
  • 85 (a)
4930430D24Rik 34
  • 83 (a)
(Bos Taurus)
Mammalia BTG1 34 33
  • 96.3 (n)
(Rattus norvegicus)
Mammalia Btg1 33
  • 96.3 (n)
(Monodelphis domestica)
Mammalia BTG1 34
  • 96 (a)
(Canis familiaris)
Mammalia BTG1 34
  • 86 (a)
(Gallus gallus)
Aves BTG1 34 33
  • 91.12 (n)
(Anolis carolinensis)
Reptilia BTG1 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia btg1 33
  • 74.16 (n)
MGC75680 33
African clawed frog
(Xenopus laevis)
Amphibia btg1-prov 33
(Danio rerio)
Actinopterygii btg1 34 33
  • 70.63 (n)
wufb14h05 33
fruit fly
(Drosophila melanogaster)
Insecta Tob 34
  • 9 (a)
Species where no ortholog for BTG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTG1 Gene

Gene Tree for BTG1 (if available)
Gene Tree for BTG1 (if available)
Evolutionary constrained regions (ECRs) for BTG1: view image

Paralogs for BTG1 Gene

Paralogs for BTG1 Gene

(5) SIMAP similar genes for BTG1 Gene using alignment to 3 proteins:

  • F8W0U7_HUMAN
  • Q6IBC8_HUMAN Pseudogenes for BTG1 Gene

genes like me logo Genes that share paralogs with BTG1: view

Variants for BTG1 Gene

Sequence variations from dbSNP and Humsavar for BTG1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000216168 -- 92,143,859(-) T/A 3_prime_UTR_variant
rs1000247244 -- 92,144,120(-) C/G coding_sequence_variant, missense_variant
rs1001018643 -- 92,146,320(-) A/G upstream_transcript_variant
rs1001496799 -- 92,147,656(-) C/T upstream_transcript_variant
rs1001702436 -- 92,143,148(-) ATTTATT/ATT 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for BTG1 Gene

Variant ID Type Subtype PubMed ID
nsv559760 CNV loss 21841781
nsv559761 CNV gain 21841781
nsv7234 OTHER inversion 18451855
nsv952463 CNV duplication 24416366

Variation tolerance for BTG1 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTG1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTG1 Gene

Disorders for BTG1 Gene


  • Note=A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC. {ECO:0000269 PubMed:2069907}.

Additional Disease Information for BTG1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BTG1 Gene.

No data available for MalaCards and Genatlas for BTG1 Gene

Publications for BTG1 Gene

  1. Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis. (PMID: 19515430) Camiña-Tato M … Comabella M (Journal of neuroimmunology 2009) 3 22 44 58
  2. An anti-proliferative gene BTG1 regulates angiogenesis in vitro. (PMID: 15033446) Iwai K … Yokoyama M (Biochemical and biophysical research communications 2004) 2 3 22 58
  3. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. (PMID: 11136725) Prévôt D … Corbo L (The Journal of biological chemistry 2001) 3 4 22 58
  4. BTG1, a member of a new family of antiproliferative genes. (PMID: 1373383) Rouault JP … Magaud JP (The EMBO journal 1992) 3 4 22 58
  5. Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. (PMID: 15674337) Busson M … Cabello G (Oncogene 2005) 3 22 58

Products for BTG1 Gene

Sources for BTG1 Gene

Loading form....