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Aliases for BTF3L4 Gene

Aliases for BTF3L4 Gene

  • Basic Transcription Factor 3 Like 4 2 3 5
  • Transcription Factor BTF3 Homolog 4 3
  • Basic Transcription Factor 3-Like 4 4

External Ids for BTF3L4 Gene

Previous GeneCards Identifiers for BTF3L4 Gene

  • GC01P052234
  • GC01P052294
  • GC01P052521
  • GC01P050639

Summaries for BTF3L4 Gene

GeneCards Summary for BTF3L4 Gene

BTF3L4 (Basic Transcription Factor 3 Like 4) is a Protein Coding gene. An important paralog of this gene is BTF3.

Additional gene information for BTF3L4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTF3L4 Gene

Genomics for BTF3L4 Gene

GeneHancer (GH) Regulatory Elements for BTF3L4 Gene

Promoters and enhancers for BTF3L4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J052053 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.3 -296 4.4 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 TXNDC12 BTF3L4 GC01M052055 PIR60864 KTI12 LOC100190934 PRPF38A ENSG00000230953 TUT4 ENSG00000223390
GH01J052032 Promoter/Enhancer 1.6 Ensembl ENCODE 11.9 -22.7 -22729 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 KTI12 ENSG00000223390 TUT4 PRPF38A ENSG00000266993 CC2D1B BTF3L4 TXNDC12 ENSG00000272100 ORC1
GH01J052550 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.4 +496.8 496774 5.6 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B CBX5 ZNF207 TUT4 ENSG00000272371 ENSG00000228838 PRPF38A MAGOH ENSG00000266993 CC2D1B RPS13P2 ENSG00000230953 GPX7
GH01J052059 Enhancer 0.5 Ensembl 0.7 +3.3 3276 0.8 JUND ZNF362 JUN CEBPB CEBPG EP300 LOC100190934 PIR60864 BTF3L4 PIR34571
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BTF3L4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTF3L4 gene promoter:
  • RFX1
  • c-Myb
  • Sox5
  • IRF-1
  • Elk-1
  • AML1a
  • HOXA3
  • FOXJ2
  • IRF-2

Genomic Locations for BTF3L4 Gene

Genomic Locations for BTF3L4 Gene
chr1:52,056,125-52,090,716
(GRCh38/hg38)
Size:
34,592 bases
Orientation:
Plus strand
chr1:52,521,797-52,556,388
(GRCh37/hg19)
Size:
34,592 bases
Orientation:
Plus strand

Genomic View for BTF3L4 Gene

Genes around BTF3L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTF3L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTF3L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTF3L4 Gene

Proteins for BTF3L4 Gene

  • Protein details for BTF3L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K17-BT3L4_HUMAN
    Recommended name:
    Transcription factor BTF3 homolog 4
    Protein Accession:
    Q96K17
    Secondary Accessions:
    • B3KNJ1
    • D3DQ32
    • G3V1C6

    Protein attributes for BTF3L4 Gene

    Size:
    158 amino acids
    Molecular mass:
    17271 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTF3L4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTF3L4 Gene

Post-translational modifications for BTF3L4 Gene

  • Ubiquitination at posLast=115115
  • Modification sites at PhosphoSitePlus

Other Protein References for BTF3L4 Gene

No data available for DME Specific Peptides for BTF3L4 Gene

Domains & Families for BTF3L4 Gene

Gene Families for BTF3L4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BTF3L4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K17

UniProtKB/Swiss-Prot:

BT3L4_HUMAN :
  • Belongs to the NAC-beta family.
Family:
  • Belongs to the NAC-beta family.
genes like me logo Genes that share domains with BTF3L4: view

Function for BTF3L4 Gene

Gene Ontology (GO) - Molecular Function for BTF3L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BTF3L4: view
genes like me logo Genes that share phenotypes with BTF3L4: view

Animal Model Products

miRNA for BTF3L4 Gene

miRTarBase miRNAs that target BTF3L4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTF3L4 Gene

Localization for BTF3L4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTF3L4 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BTF3L4 Gene

Pathways & Interactions for BTF3L4 Gene

SuperPathways for BTF3L4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTF3L4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BTF3L4 Gene

Drugs & Compounds for BTF3L4 Gene

No Compound Related Data Available

Transcripts for BTF3L4 Gene

mRNA/cDNA for BTF3L4 Gene

Unigene Clusters for BTF3L4 Gene

Basic transcription factor 3-like 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTF3L4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4: -

Relevant External Links for BTF3L4 Gene

GeneLoc Exon Structure for
BTF3L4
ECgene alternative splicing isoforms for
BTF3L4

Expression for BTF3L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTF3L4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BTF3L4 Gene

This gene is overexpressed in Fetal ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BTF3L4 Gene



Protein tissue co-expression partners for BTF3L4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BTF3L4 Gene:

BTF3L4

SOURCE GeneReport for Unigene cluster for BTF3L4 Gene:

Hs.429839

Evidence on tissue expression from TISSUES for BTF3L4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with BTF3L4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTF3L4 Gene

Orthologs for BTF3L4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BTF3L4 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia BTF3L4 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTF3L4 34
  • 100 (a)
OneToOne
LOC100687058 33
  • 97.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BTF3L4 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTF3L4 34 33
  • 99.79 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BTF3L4 34 33
  • 95.78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Btf3l4 16 34 33
  • 93.88 (n)
rat
(Rattus norvegicus)
Mammalia Btf3l4 33
  • 93.88 (n)
chicken
(Gallus gallus)
Aves BTF3L4 34 33
  • 88.19 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTF3L4 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btf3l4 33
  • 82.49 (n)
zebrafish
(Danio rerio)
Actinopterygii btf3l4 34 34
  • 96 (a)
OneToMany
LOC100006097 33
  • 80.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta bic 34
  • 61 (a)
ManyToMany
CG11835 34
  • 13 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea icd-1 34 33
  • 65.29 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EGD1 36 34
  • 38 (a)
BTT1 34
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1484 34
  • 72 (a)
OneToMany
Species where no ortholog for BTF3L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTF3L4 Gene

ENSEMBL:
Gene Tree for BTF3L4 (if available)
TreeFam:
Gene Tree for BTF3L4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for BTF3L4: view image

Paralogs for BTF3L4 Gene

Paralogs for BTF3L4 Gene

(1) SIMAP similar genes for BTF3L4 Gene using alignment to 4 proteins:

  • BT3L4_HUMAN
  • E9PL10_HUMAN
  • E9PPC3_HUMAN
  • Q6PJ77_HUMAN
genes like me logo Genes that share paralogs with BTF3L4: view

Variants for BTF3L4 Gene

Sequence variations from dbSNP and Humsavar for BTF3L4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000121926 -- 52,075,666(+) T/A intron_variant
rs1000206401 -- 52,056,239(+) G/C 5_prime_UTR_variant
rs1000217244 -- 52,065,599(+) A/C intron_variant
rs1000285150 -- 52,069,488(+) A/G intron_variant
rs1000305585 -- 52,075,837(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTF3L4 Gene

Variant ID Type Subtype PubMed ID
nsv1004103 CNV loss 25217958
nsv829848 CNV loss 17160897
nsv945943 CNV duplication 23825009
nsv945944 CNV duplication 23825009

Variation tolerance for BTF3L4 Gene

Residual Variation Intolerance Score: 53.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTF3L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTF3L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTF3L4 Gene

Disorders for BTF3L4 Gene

Additional Disease Information for BTF3L4

No disorders were found for BTF3L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTF3L4 Gene

Publications for BTF3L4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for BTF3L4 Gene

Sources for BTF3L4 Gene

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