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BTC Gene(Protein Coding)

Betacellulin

GCID:
GC04M074744
GIFtS:
55
Genes Participants
UDN Logo

Aliases for BTC Gene

Aliases for BTC Gene

  • Betacellulin 2 3 5
  • Probetacellulin 3

External Ids for BTC Gene

Previous GeneCards Identifiers for BTC Gene

  • GC04M075557
  • GC04M075843
  • GC04M076062
  • GC04M076128
  • GC04M076129
  • GC04M076027
  • GC04M075889
  • GC04M075669
  • GC04M071418

Summaries for BTC Gene

Entrez Gene Summary for BTC Gene

  • This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for BTC Gene

BTC (Betacellulin) is a Protein Coding gene. Diseases associated with BTC include Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is TGFA.

UniProtKB/Swiss-Prot for BTC Gene

  • Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Gene Wiki entry for BTC Gene

Additional gene information for BTC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTC Gene

Genomics for BTC Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for BTC Gene

Promoters and enhancers for BTC Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04I074793 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 588.5 +0.5 508 1.6 SIN3A FEZF1 RAD21 YY1 ZNF335 ZNF143 RXRA ZBTB11 USF2 ZNF398 BTC ENSG00000249942
GH04I074796 Enhancer 0.2 FANTOM5 567.1 -1.6 -1621 0.4 BTC GC04P074814
GH04I074932 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 6.3 -139.4 -139364 2.5 ZNF76 SIN3A RAD21 ZNF335 GLIS2 ZNF213 ZSCAN5C SCRT2 ZNF143 ATF7 PARM1 BTC LOC100507388
GH04I074768 Enhancer 0.7 ENCODE 4.6 +25.5 25522 0.7 CTCF FOXA2 JUN ZBTB40 ZEB1 HIC1 ZFHX2 GATA3 FOSL2 NR2F6 BTC ENSG00000249942
GH04I074623 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.1 +169.7 169746 3.6 PKNOX1 ATF1 FOXA2 FEZF1 ZNF2 ZNF143 FOS ATF7 REST TSHZ1 ENSG00000249942 BTC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BTC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BTC gene promoter:

Genomic Locations for BTC Gene

Genomic Locations for BTC Gene
chr4:74,744,759-74,794,686
(GRCh38/hg38)
Size:
49,928 bases
Orientation:
Minus strand
chr4:75,669,969-75,719,896
(GRCh37/hg19)

Genomic View for BTC Gene

Genes around BTC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTC Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for BTC Gene

Proteins for BTC Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for BTC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35070-BTC_HUMAN
    Recommended name:
    Probetacellulin
    Protein Accession:
    P35070
    Secondary Accessions:
    • Q96F48

    Protein attributes for BTC Gene

    Size:
    178 amino acids
    Molecular mass:
    19746 Da
    Quaternary structure:
    • Monomer. Interacts with EGFR and ERBB4.

    Three dimensional structures from OCA and Proteopedia for BTC Gene

neXtProt entry for BTC Gene

Protein Expression for BTC Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for BTC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BTC Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

No data available for DME Specific Peptides for BTC Gene

Domains & Families for BTC Gene

Gene Families for BTC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for BTC Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BTC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BTC: view

No data available for UniProtKB/Swiss-Prot for BTC Gene

Function for BTC Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for BTC Gene

GENATLAS Biochemistry:
betacellulin,ECF family
UniProtKB/Swiss-Prot Function:
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Phenotypes From GWAS Catalog for BTC Gene

Gene Ontology (GO) - Molecular Function for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005154 epidermal growth factor receptor binding IBA,IEA --
GO:0005515 protein binding IPI 19740107
GO:0008083 growth factor activity IBA --
genes like me logo Genes that share ontologies with BTC: view
genes like me logo Genes that share phenotypes with BTC: view

Animal Models for BTC Gene

MGI Knock Outs for BTC:

Animal Model Products

Clone Products

  • Addgene plasmids for BTC

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BTC Gene

Localization for BTC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTC Gene

Betacellulin: Secreted, extracellular space.
Probetacellulin: Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BTC gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BTC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for BTC Gene

Pathways & Interactions for BTC Gene

SuperPathways for BTC Gene

PathCards logo More details on SuperPathways for BTC
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
3 Signaling by ERBB2
Downregulation of ERBB2 signaling
.59
Signaling by ERBB2
.59
SHC1 events in ERBB2 signaling
.43
ERBB2 Activates PTK6 Signaling
.01
ERBB2 Regulates Cell Motility
.01
GRB2 events in ERBB2 signaling
.01
PI3K events in ERBB2 signaling
.01
PI3K events in ERBB4 signaling
.01
SHC1 events in ERBB4 signaling
.01
4 PI3K/AKT activation
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
Constitutive Signaling by Aberrant PI3K in Cancer
.75
PI3K/AKT Signaling in Cancer
.72
5 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
genes like me logo Genes that share pathways with BTC: view

SIGNOR curated interactions for BTC Gene

Activates:

Gene Ontology (GO) - Biological Process for BTC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007173 epidermal growth factor receptor signaling pathway IEA,IBA --
GO:0008284 positive regulation of cell proliferation IEA,TAS 8144591
GO:0010469 regulation of receptor activity IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with BTC: view

Drugs & Compounds for BTC Gene

Products:

  1. Drug

(19) Drugs for BTC Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 784
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 2906
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2100
Lenvatinib Approved, Investigational Pharma Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 68
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1560

(7) Additional Compounds for BTC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BTC: view

Transcripts for BTC Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for BTC Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BTC Gene

Betacellulin:
Representative Sequences:

Clone Products

  • Addgene plasmids for BTC

Alternative Splicing Database (ASD) splice patterns (SP) for BTC Gene

No ASD Table

Relevant External Links for BTC Gene

GeneLoc Exon Structure for
BTC
ECgene alternative splicing isoforms for
BTC

Expression for BTC Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BTC Gene

mRNA expression in normal human tissues for BTC Gene
mRNA expression by GTEx for BTC GenemRNA expression by BioGPS for BTC Gene

mRNA differential expression in normal tissues according to GTEx for BTC Gene

This gene is overexpressed in Colon - Sigmoid (x7.9), Esophagus - Muscularis (x6.5), and Esophagus - Gastroesophageal Junction (x6.4).

Protein differential expression in normal tissues from HIPED for BTC Gene

This gene is overexpressed in Colon (26.4), Gallbladder (24.5), and Retina (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BTC Gene



NURSA nuclear receptor signaling pathways regulating expression of BTC Gene:

BTC

SOURCE GeneReport for Unigene cluster for BTC Gene:

Hs.710156

mRNA Expression by UniProt/SwissProt for BTC Gene:

P35070-BTC_HUMAN
Tissue specificity: Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.

Evidence on tissue expression from TISSUES for BTC Gene

  • Gall bladder(2.2)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with BTC: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for BTC Gene

Orthologs for BTC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BTC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia BTC 33 34
  • 99.25 (n)
cow
(Bos Taurus)
 Mammalia BTC 33 34
  • 89.14 (n)
dog
(Canis familiaris)
 Mammalia LOC482682 33
  • 85.56 (n)
BTC 34
  • 74 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Btc 33 16 34
  • 78.53 (n)
rat
(Rattus norvegicus)
 Mammalia Btc 33
  • 78.53 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia BTC 34
  • 55 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BTC 33 34
  • 60.28 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100497610 33
  • 60.87 (n)
zebrafish
(Danio rerio)
 Actinopterygii btc 33 34
  • 56.05 (n)
Species where no ortholog for BTC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTC Gene

ENSEMBL:
Gene Tree for BTC (if available)
TreeFam:
Gene Tree for BTC (if available)

Paralogs for BTC Gene

Paralogs for BTC Gene

(1) SIMAP similar genes for BTC Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BTC: view

Variants for BTC Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for BTC Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000057924 -- 74,768,937(-) A/C/G 3_prime_UTR_variant, intron_variant
rs10000837 -- 74,783,998(-) C/T intron_variant
rs1000175724 -- 74,785,217(-) G/A intron_variant
rs1000210775 -- 74,768,952(-) C/A 3_prime_UTR_variant, intron_variant
rs1000267510 -- 74,774,869(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BTC Gene

Variant ID Type Subtype PubMed ID
esv3601020 CNV loss 21293372
nsv1009099 CNV gain 25217958
nsv4390 CNV deletion 18451855
nsv7363 OTHER inversion 18451855

Variation tolerance for BTC Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.13; 92.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BTC Gene

Human Gene Mutation Database (HGMD)
BTC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BTC

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTC Gene

Disorders for BTC Gene

MalaCards: The human disease database

(1) MalaCards diseases for BTC Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 1
  • cmh1
- elite association - COSMIC cancer census association via MalaCards
Search BTC in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BTC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BTC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BTC Gene

Publications for BTC Gene

  1. Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. (PMID: 8439318) Sasada R … Igarashi K (Biochemical and biophysical research communications 1993) 2 3 4 22 58
  2. Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations. (PMID: 16683131) Silver KD … Mitchell BD (Journal of molecular medicine (Berlin, Germany) 2006) 3 22 44 58
  3. Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects. (PMID: 16869959) Elbein SC … Silver KD (BMC medical genetics 2006) 3 22 44 58
  4. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. (PMID: 15793259) Silver K … Mitchell BD (Diabetes 2005) 3 22 44 58
  5. Molecular scanning of the betacellulin gene for mutations in type 2 diabetic patients. (PMID: 15936459) Nakagawa T … Nanjo K (Diabetes research and clinical practice 2005) 3 22 44 58

Products for BTC Gene

  • Addgene plasmids for BTC

Sources for BTC Gene

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