Aliases for BTBD18 Gene
External Ids for BTBD18 Gene
Previous GeneCards Identifiers for BTBD18 Gene
GeneCards Summary for BTBD18 Gene
BTBD18 (BTB Domain Containing 18) is a Protein Coding gene. An important paralog of this gene is KLHL20.
UniProtKB/Swiss-Prot Summary for BTBD18 Gene
Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.